DegronMD

Uniprot ID: A8MVX0

Source protein: Rho guanine nucleotide exchange factor 33

Source gene: ARHGEF33

Class: DEG_SCF_FBW7_2

Location: 192:198

E3 ligase: FBXW7

DEGRON score: 0.8214

ASA_SCORE: 77.6429

COIL: 0.5516

CONS_SCORE: 0.5765

DSS_SCORE: 0.6192

HELIX: 0.4411

FCONS_SCORE: 1.0567

RIG_SCORE: 0.6947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T193S	TCGA-AA-3492	COAD	TCGA	PTTPEAE	DEG_SCF_FBW7_2	0.6005
p.T193S	DO8224	COAD	ICGC	PTTPEAE	DEG_SCF_FBW7_2	0.6005
p.L205I	TCGA-L5-A8NM	ESCA	TCGA	PTTPEAE	DEG_SCF_FBW7_2	0.1389
p.P192T	DO233941	GACA	ICGC	PTTPEAE	DEG_SCF_FBW7_2	0.7031
p.E198A	DO26971	LUSC	ICGC	PTTPEAE	DEG_SCF_FBW7_2	0.7701

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MVX0	Rho guanine nucleotide exchange factor 33	DEG_SCF_FBW7_2	192:198	PTTPEAE	FBXW7	0.8214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons