DegronMD - P05412(JUN)

GO - Biological processes (BP): angiogenesis [GO:0001525]; axon regeneration [GO:0031103]; cellular response to anisomycin [GO:0072740]; cellular response to cadmium ion [GO:0071276]; cellular response to calcium ion [GO:0071277]; cellular response to reactive oxygen species [GO:0034614]; eyelid development in camera-type eye [GO:0061029]; integrated stress response signaling [GO:0140467]; leading edge cell differentiation [GO:0035026]; liver development [GO:0001889]; microglial cell activation [GO:0001774]; monocyte differentiation [GO:0030224]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA binding [GO:0043392]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; outflow tract morphogenesis [GO:0003151]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; response to muscle stretch [GO:0035994]; response to xenobiotic stimulus [GO:0009410]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G86W	TCGA-44-7667	LUAD	TCGA	ITTTPTPT	DEG_SCF_FBW7_1	88:95	Mutation rewiring degron network	0.2778
p.G86W	DO23830	LUAD	ICGC	ITTTPTPT	DEG_SCF_FBW7_1	88:95	Mutation rewiring degron network	0.2778
p.C99Y	TCGA-B5-A1MR	UCEC	TCGA	ITTTPTPT	DEG_SCF_FBW7_1	88:95	Mutation rewiring degron network	0.2222
p.C99Y	DO41758	UCEC	ICGC	ITTTPTPT	DEG_SCF_FBW7_1	88:95	Mutation rewiring degron network	0.2222
p.P244L	TCGA-K7-A5RG	LIHC	TCGA	EEPQTVPEM	DEG_COP1_1	227:235	Mutation rewiring degron network	0.0833
p.P244L	TCGA-K7-A5RG	LIHC	TCGA	PGETPPLS	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.3056
p.P244L	DO52304	LIHC	ICGC	EEPQTVPEM	DEG_COP1_1	227:235	Mutation rewiring degron network	0.0833
p.P244L	DO52304	LIHC	ICGC	PGETPPLS	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.3056
p.P178L	TCGA-Z2-A8RT	SKCM	TCGA	PPVY	ITCH	167:170	Mutation rewiring degron network	0.1111
p.P178L	DO51301	SKCM	ICGC	PPVY	ITCH	167:170	Mutation rewiring degron network	0.1111
p.A180T	DO44096	COAD	ICGC	PPVY	ITCH	167:170	Mutation rewiring degron network	0.0556
p.A224V	DO233900	GACA	ICGC	EEPQTVPEM	DEG_COP1_1	227:235	Mutation rewiring degron network	0.25
p.T93N	DO228976	LICA	ICGC	ITTTPTPT	DEG_SCF_FBW7_1	88:95	Mutation altering degron motif	0.7055
p.T239K	DO229015	LICA	ICGC	PGETPPLS	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.8417
p.L98R	DO222708	MELA	ICGC	ITTTPTPT	DEG_SCF_FBW7_1	88:95	Mutation rewiring degron network	0.25
p.G158S	DO46757	PAEN	ICGC	PPVY	ITCH	167:170	Mutation rewiring degron network	0.0833
p.S165T	DO43210	UCEC	ICGC	PPVY	ITCH	167:170	Mutation rewiring degron network	0.2778
p.H87R	SIDM00924	Other Solid Cancers	GDSC	ITTTPTPT	DEG_SCF_FBW7_1	88:95	Mutation rewiring degron network	0.3056
p.H87R	ACH-000867	Lung Cancer	CCLE	ITTTPTPT	DEG_SCF_FBW7_1	88:95	Mutation rewiring degron network	0.3056
p.H87R	ChaGo-K-1	lung	COSMIC	ITTTPTPT	DEG_SCF_FBW7_1	88:95	Mutation rewiring degron network	0.3056
p.E234D	SIDM00296	Small Cell Lung Carcinoma	GDSC	EEPQTVPEM	DEG_COP1_1	227:235	Mutation altering degron motif	0.5647
p.E234D	ACH-002051	Lung Cancer	CCLE	EEPQTVPEM	DEG_COP1_1	227:235	Mutation altering degron motif	0.5647
p.E234D	LU-134-A	lung	COSMIC	EEPQTVPEM	DEG_COP1_1	227:235	Mutation altering degron motif	0.5647
p.L225M	SIDM00282	Colorectal Carcinoma	GDSC	EEPQTVPEM	DEG_COP1_1	227:235	Mutation rewiring degron network	0.2778
p.L225M	ACH-000998	Colon/Colorectal Cancer	CCLE	EEPQTVPEM	DEG_COP1_1	227:235	Mutation rewiring degron network	0.2778
p.L225M	CW-2	large intestine	COSMIC	EEPQTVPEM	DEG_COP1_1	227:235	Mutation rewiring degron network	0.2778

Kaplan plot for JUN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JUN

UniProt ID: P05412

Entrez ID: 3725

Protein name: Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JUN in