DegronMD

Uniprot ID: P05412

Source protein: Transcription factor Jun

Source gene: JUN

Class: DEG_SCF_FBW7_1

Location: 88:95

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 75.2

COIL: 0.8816

CONS_SCORE: 0.5484

DSS_SCORE: 0.4727

HELIX: 0.0308

FCONS_SCORE: 1.0417

RIG_SCORE: 0.7242

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G86W	TCGA-44-7667	LUAD	TCGA	ITTTPTPT	DEG_SCF_FBW7_1	0.2778
p.G86W	DO23830	LUAD	ICGC	ITTTPTPT	DEG_SCF_FBW7_1	0.2778
p.C99Y	TCGA-B5-A1MR	UCEC	TCGA	ITTTPTPT	DEG_SCF_FBW7_1	0.2222
p.C99Y	DO41758	UCEC	ICGC	ITTTPTPT	DEG_SCF_FBW7_1	0.2222
p.T93N	DO228976	LICA	ICGC	ITTTPTPT	DEG_SCF_FBW7_1	0.7055
p.L98R	DO222708	MELA	ICGC	ITTTPTPT	DEG_SCF_FBW7_1	0.25
p.H87R	SIDM00924	Other Solid Cancers	GDSC	ITTTPTPT	DEG_SCF_FBW7_1	0.3056
p.H87R	ACH-000867	Lung Cancer	CCLE	ITTTPTPT	DEG_SCF_FBW7_1	0.3056
p.H87R	ChaGo-K-1	lung	COSMIC	ITTTPTPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05412	Transcription factor Jun	DEG_SCF_FBW7_1	88:95	ITTTPTPT	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons