DegronMD

Uniprot ID: P05412

Source protein: Transcription factor Jun

Source gene: JUN

Class: DEG_COP1_1

Location: 227:235

E3 ligase: COP1

DEGRON score: 0.9958

ASA_SCORE: 109.5111

COIL: 0.9336

CONS_SCORE: 0.5498

DSS_SCORE: 0.811

HELIX: 0.0369

FCONS_SCORE: 1.1406

RIG_SCORE: 0.6006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P244L	TCGA-K7-A5RG	LIHC	TCGA	EEPQTVPEM	DEG_COP1_1	0.0833
p.P244L	DO52304	LIHC	ICGC	EEPQTVPEM	DEG_COP1_1	0.0833
p.A224V	DO233900	GACA	ICGC	EEPQTVPEM	DEG_COP1_1	0.25
p.E234D	SIDM00296	Small Cell Lung Carcinoma	GDSC	EEPQTVPEM	DEG_COP1_1	0.5647
p.E234D	ACH-002051	Lung Cancer	CCLE	EEPQTVPEM	DEG_COP1_1	0.5647
p.E234D	LU-134-A	lung	COSMIC	EEPQTVPEM	DEG_COP1_1	0.5647
p.L225M	SIDM00282	Colorectal Carcinoma	GDSC	EEPQTVPEM	DEG_COP1_1	0.2778
p.L225M	ACH-000998	Colon/Colorectal Cancer	CCLE	EEPQTVPEM	DEG_COP1_1	0.2778
p.L225M	CW-2	large_intestine	COSMIC	EEPQTVPEM	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05412	Transcription factor Jun	DEG_COP1_1	227:235	EEPQTVPEM	COP1	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons