DegronMD

Uniprot ID: P05412

Source protein: Transcription factor Jun

Source gene: JUN

Class: DEG_SCF_FBW7_1

Location: 236:243

E3 ligase: FBXW7

DEGRON score: 0.975

ASA_SCORE: 91.7125

COIL: 0.9665

CONS_SCORE: 0.5124

DSS_SCORE: 0.7696

HELIX: 0.0159

FCONS_SCORE: 0.8379

RIG_SCORE: 0.5893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P244L	TCGA-K7-A5RG	LIHC	TCGA	PGETPPLS	DEG_SCF_FBW7_1	0.3056
p.P244L	DO52304	LIHC	ICGC	PGETPPLS	DEG_SCF_FBW7_1	0.3056
p.T239K	DO229015	LICA	ICGC	PGETPPLS	DEG_SCF_FBW7_1	0.8417

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05412	Transcription factor Jun	DEG_SCF_FBW7_1	236:243	PGETPPLS	FBXW7	0.975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons