DegronMD - Q9BYN7(ZNF341)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P763Q	TCGA-05-4396	LUAD	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.7035
p.R754H	TCGA-A5-A1OF	UCEC	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1667
p.R754H	DO51164	GBM	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1667
p.R754H	DO42608	UCEC	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1667
p.R754H	SIDM02035	Colorectal Carcinoma	GDSC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1667
p.R754C	TCGA-AJ-A3EL	UCEC	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1667
p.L246I	TCGA-AX-A1C4	UCEC	TCGA	PPVY	ITCH	255:258	Mutation rewiring degron network	0.0833
p.L246I	DO42480	UCEC	ICGC	PPVY	ITCH	255:258	Mutation rewiring degron network	0.0833
p.Q251H	TCGA-BP-4964	KIRC	TCGA	PPVY	ITCH	255:258	Mutation rewiring degron network	0.2222
p.Q251H	DO16263	KIRC	ICGC	PPVY	ITCH	255:258	Mutation rewiring degron network	0.2222
p.P261T	TCGA-D3-A2JN	SKCM	TCGA	PPVY	ITCH	255:258	Mutation rewiring degron network	0.25
p.P261T	DO47590	SKCM	ICGC	PPVY	ITCH	255:258	Mutation rewiring degron network	0.25
p.K770N	TCGA-DF-A2KN	UCEC	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.2778
p.P261L	TCGA-EE-A2M6	SKCM	TCGA	PPVY	ITCH	255:258	Mutation rewiring degron network	0.25
p.P261L	DO222514	MELA	ICGC	PPVY	ITCH	255:258	Mutation rewiring degron network	0.25
p.P261L	DO37976	SKCM	ICGC	PPVY	ITCH	255:258	Mutation rewiring degron network	0.25
p.P759S	TCGA-FW-A3R5	SKCM	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.3056
p.G765W	TCGA-HE-7129	KIRP	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.7825
p.R761C	DO222981	BTCA	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.8301
p.R761C	DO41542	UCEC	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.8301
p.G772W	DO20786	KIRP	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.2222
p.P770Q	DO23838	LUAD	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.2778
p.P766L	DO222595	MELA	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.6471
p.P753T	DO37423	SKCM	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1389
p.P766S	DO37406	SKCM	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.5641
p.K777N	DO223282	UCEC	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation substituting flanking lysine	0.1944
p.R761H	DO42568	UCEC	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.8244
p.P768S	SIDM00683	Prostate Carcinoma	GDSC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.5641
p.P768S	LNCaP-Clone-FGC	prostate	COSMIC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.5641
p.G757S	SIDM00081	Melanoma	GDSC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.25
p.G757S	SK-MEL-28	skin	COSMIC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.25
p.P249S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPVY	ITCH	255:258	Mutation rewiring degron network	0.1667
p.P249S	ACH-001127	Leukemia	CCLE	PPVY	ITCH	255:258	Mutation rewiring degron network	0.1667
p.P249S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPVY	ITCH	255:258	Mutation rewiring degron network	0.1667
p.N250Y	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPVY	ITCH	255:258	Mutation rewiring degron network	0.1944
p.P761S	ACH-000977	lymph node	CCLE	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.6752
p.P761S	LNCaP-Clone-FGC	prostate	COSMIC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.6752
p.G752D	ACH-001347	Head and Neck Cancer	CCLE	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1111
p.G750S	SK-MEL-28	skin	COSMIC	GRKVLTPLP	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.0556

Kaplan plot for ZNF341 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF341

UniProt ID: Q9BYN7

Entrez ID: 84905

Protein name: Zinc finger protein 341

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF341 in