DegronMD

Uniprot ID: Q9BYN7

Source protein: Zinc finger protein 341

Source gene: ZNF341

Class: DEG_APCC_DBOX_1

Location: 760:768

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9903

ASA_SCORE: 80.2889

COIL: 0.812

CONS_SCORE: 0.2721

DSS_SCORE: 0.5861

HELIX: 0.0191

FCONS_SCORE: 0.9097

RIG_SCORE: 0.6685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P763Q	TCGA-05-4396	LUAD	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	0.7035
p.R754H	TCGA-A5-A1OF	UCEC	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	0.1667
p.R754H	DO51164	GBM	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	0.1667
p.R754H	DO42608	UCEC	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	0.1667
p.R754H	SIDM02035	Colorectal Carcinoma	GDSC	GRKVLTPLP	DEG_APCC_DBOX_1	0.1667
p.R754C	TCGA-AJ-A3EL	UCEC	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	0.1667
p.K770N	TCGA-DF-A2KN	UCEC	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	0.2778
p.P759S	TCGA-FW-A3R5	SKCM	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	0.3056
p.G765W	TCGA-HE-7129	KIRP	TCGA	GRKVLTPLP	DEG_APCC_DBOX_1	0.7825
p.R761C	DO222981	BTCA	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	0.8301
p.R761C	DO41542	UCEC	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	0.8301
p.G772W	DO20786	KIRP	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	0.2222
p.P770Q	DO23838	LUAD	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	0.2778
p.P766L	DO222595	MELA	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	0.6471
p.P753T	DO37423	SKCM	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	0.1389
p.P766S	DO37406	SKCM	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	0.5641
p.K777N	DO223282	UCEC	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	0.1944
p.R761H	DO42568	UCEC	ICGC	GRKVLTPLP	DEG_APCC_DBOX_1	0.8244
p.P768S	SIDM00683	Prostate Carcinoma	GDSC	GRKVLTPLP	DEG_APCC_DBOX_1	0.5641
p.P768S	LNCaP-Clone-FGC	prostate	COSMIC	GRKVLTPLP	DEG_APCC_DBOX_1	0.5641
p.G757S	SIDM00081	Melanoma	GDSC	GRKVLTPLP	DEG_APCC_DBOX_1	0.25
p.G757S	SK-MEL-28	skin	COSMIC	GRKVLTPLP	DEG_APCC_DBOX_1	0.25
p.P761S	ACH-000977	lymph_node	CCLE	GRKVLTPLP	DEG_APCC_DBOX_1	0.6752
p.P761S	LNCaP-Clone-FGC	prostate	COSMIC	GRKVLTPLP	DEG_APCC_DBOX_1	0.6752
p.G752D	ACH-001347	Head and Neck Cancer	CCLE	GRKVLTPLP	DEG_APCC_DBOX_1	0.1111
p.G750S	SK-MEL-28	skin	COSMIC	GRKVLTPLP	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYN7	Zinc finger protein 341	DEG_APCC_DBOX_1	760:768	GRKVLTPLP	APC,CDC20,FZR1	0.9903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRKVLTPLP

Degron related mutations and impact score

Drug responses associated with ZNF341 mutations

All proteins holding degron of GRKVLTPLP