DegronMD

Uniprot ID: Q9BRR9

Source protein: Rho GTPase-activating protein 9

Source gene: ARHGAP9

Class: LIG_APCC_ABBA_1

Location: 153:158

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9685

ASA_SCORE: 99.0667

COIL: 0.8888

CONS_SCORE: 0.4699

DSS_SCORE: 0.6889

HELIX: 0.0523

FCONS_SCORE: 1.0734

RIG_SCORE: 0.662

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S164Y	TCGA-17-Z022	LUAD	TCGA	LKPFQE	LIG_APCC_ABBA_1	0.1667
p.L165I	TCGA-AD-6889	COAD	TCGA	LKPFQE	LIG_APCC_ABBA_1	0.1389
p.R163K	TCGA-ER-A193	SKCM	TCGA	LKPFQE	LIG_APCC_ABBA_1	0.1944
p.R163K	ACH-002175	Lung Cancer	CCLE	LKPFQE	LIG_APCC_ABBA_1	0.1944
p.R163K	NCI-H740	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.1944
p.S151N	TCGA-VQ-A8P2	STAD	TCGA	LKPFQE	LIG_APCC_ABBA_1	0.2778
p.Y161F	DO51927	BLCA	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.6944
p.R145C	DO1618	BRCA	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.1111
p.R145C	DO3846	BRCA	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.1111
p.R145C	DO10164	COAD	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.1111
p.R145C	DO227709	COCA	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.1111
p.R145C	DO12226	GBM	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.1111
p.R145C	DO25669	LUAD	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.1111
p.R145C	DO228626	PRAD	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.1111
p.R145C	DO51391	PRAD	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.1111
p.R145C	DO41097	UCEC	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.1111
p.A159V	DO8786	COAD	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.3056
p.A143T	DO227802	COCA	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.0556
p.V157I	DO233207	GACA	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.7076
p.V157I	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.7076
p.P149S	DO10992	GBM	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.2222
p.S166A	DO225404	LAML	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.5556
p.S166A	NUGC-4	stomach	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.5556
p.P158Q	DO229009	LICA	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.7035
p.E164K	DO37406	SKCM	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.1667
p.P168S	DO48665	SKCM	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.0556
p.F156V	DO41211	UCEC	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.7068
p.E165K	DO41404	UCEC	ICGC	LKPFQE	LIG_APCC_ABBA_1	0.1389
p.V167G	SIDM01314	Colorectal Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	0.0833
p.S158A	SIDM00570	Gastric Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	0.7588
p.S158A	NUGC-4	stomach	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.7588
p.I155T	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	0.7078
p.I155T	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.7078
p.V149I	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	0.2222
p.V149I	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.2222
p.F148L	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	0.1944
p.F148L	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.1944
p.E156Q	SIDM00614	Hepatocellular Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	0.6744
p.E156Q	JHH-7	liver	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.6744
p.Q162K	SIDM00660	Colorectal Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	0.2222
p.Q162K	LS-411N	large_intestine	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.2222
p.R145Q	SIDM00523	Small Cell Lung Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	0.1111
p.R145Q	DMS-53	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.1111
p.P146H	SIDM00118	Colorectal Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	0.1389
p.P146H	HCC2998	large_intestine	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.1389
p.P146S	SIDM00500	Colorectal Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	0.1389
p.P154H	HCC2998	large_intestine	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.7694
p.A151G	NCI-H1703	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.2778
p.F156L	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.6981
p.R153Q	DMS-53	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.7329
p.I163T	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.1944
p.E164Q	JHH-7	liver	COSMIC	LKPFQE	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKPFQE

Degron related mutations and impact score

Drug responses associated with ARHGAP9 mutations

All proteins holding degron of LKPFQE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRR9	Rho GTPase-activating protein 9	LIG_APCC_ABBA_1	153:158	LKPFQE	APC,CDC20,FZR1	0.9685	More...