DegronMD

Uniprot ID: Q92738

Source protein: USP6 N-terminal-like protein

Source gene: USP6NL

Class: DEG_ODPH_VHL_1

Location: 769:782

E3 ligase: VHL

DEGRON score: 0.9952

ASA_SCORE: 62.5714

COIL: 0.836

CONS_SCORE: 0.247

DSS_SCORE: 0.3882

HELIX: 0.0925

FCONS_SCORE: 0.9708

RIG_SCORE: 0.716

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S774N	TCGA-34-5239	LUSC	TCGA	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.7069
p.A787V	TCGA-51-4081	LUSC	TCGA	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.1944
p.S774G	TCGA-AP-A056	UCEC	TCGA	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.6993
p.A787T	TCGA-DF-A2KN	UCEC	TCGA	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.1944
p.A787T	DO233935	GACA	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.1944
p.A787T	DO223282	UCEC	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.1944
p.R775H	DO227996	COCA	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.8244
p.R775S	DO229038	LICA	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.7427
p.S780N	DO27660	LUSC	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.7069
p.QG765QR	DO222662	MELA	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.4444
p.S780G	DO43971	UCEC	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.6993
p.D772Y	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.7325
p.D772Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.7325
p.G776D	SIDM00683	Prostate Carcinoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.6087
p.G776D	SIDM00534	Colorectal Carcinoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.6087
p.G776D	HT-115	large_intestine	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.6087
p.G776D	LNCaP-Clone-FGC	prostate	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.6087
p.T764M	SIDM00329	Hodgkin's Lymphoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.6389
p.T764M	SIDM01106	Melanoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.6389
p.T764M	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.6389
p.T764M	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.6389
p.R761K	SIDM01735	Biliary Tract Carcinoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.1111
p.G759D	ACH-000977	lymph_node	CCLE	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.0556
p.G759D	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.0556
p.G759D	HT-115	large_intestine	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.0556
p.G759D	LNCaP-Clone-FGC	prostate	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.0556
p.G782D	HT-115	large_intestine	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.7198
p.G782D	LNCaP-Clone-FGC	prostate	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.7198
p.D778Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	0.7325

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPFQDHGLPAVSV

Degron related mutations and impact score

Drug responses associated with USP6NL mutations

All proteins holding degron of LAPFQDHGLPAVSV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92738	USP6 N-terminal-like protein	DEG_ODPH_VHL_1	769:782	LAPFQDHGLPAVSV	VHL	0.9952	More...