DegronMD

Uniprot ID: Q15303

Source protein: Receptor tyrosine-protein kinase erbB-4

Source gene: ERBB4

Class: ITCH

Location: 1298:1301

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9446

ASA_SCORE: 80.875

COIL: 0.9148

CONS_SCORE: 0.1616

DSS_SCORE: 0.5186

HELIX: 0.0445

FCONS_SCORE: 1.0999

RIG_SCORE: 0.6542

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1308L	TCGA-39-5034	LUSC	TCGA	PPPY	ITCH	0.1389
p.R1304L	TCGA-68-7757	LUSC	TCGA	PPPY	ITCH	0.25
p.R1304L	TCGA-78-7148	LUAD	TCGA	PPPY	ITCH	0.25
p.H1303Q	TCGA-80-5608	LUAD	TCGA	PPPY	ITCH	0.2778
p.H1303Q	TCGA-A3-A8OX	KIRC	TCGA	PPPY	ITCH	0.2778
p.P1292S	TCGA-A8-A08A	BRCA	TCGA	PPPY	ITCH	0.1667
p.K1291N	TCGA-B5-A0JY	UCEC	TCGA	PPPY	ITCH	0.25
p.P1300S	TCGA-BF-AAP4	SKCM	TCGA	PPPY	ITCH	0.5641
p.R1304W	TCGA-DF-A2KU	UCEC	TCGA	PPPY	ITCH	0.25
p.P1300L	TCGA-FU-A5XV	CESC	TCGA	PPPY	ITCH	0.6471
p.P1290L	DO48996	CESC	ICGC	PPPY	ITCH	0.1111
p.R1294W	DO233749	GACA	ICGC	PPPY	ITCH	0.2222
p.R1294W	DO223286	UCEC	ICGC	PPPY	ITCH	0.2222
p.H1293Q	DO49690	KIRC	ICGC	PPPY	ITCH	0.1944
p.H1293Q	DO23693	LUAD	ICGC	PPPY	ITCH	0.1944
p.R1294L	DO26112	LUAD	ICGC	PPPY	ITCH	0.2222
p.R1294L	DO26886	LUSC	ICGC	PPPY	ITCH	0.2222
p.V1298L	DO26854	LUSC	ICGC	PPPY	ITCH	0.6765
p.P1290S	DO219468	SKCM	ICGC	PPPY	ITCH	0.1111
p.P1297L	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	0.3056
p.P1297L	ACH-001669	Leukemia	CCLE	PPPY	ITCH	0.3056
p.P1297L	ACH-002238	Leukemia	CCLE	PPPY	ITCH	0.3056
p.P1297L	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PPPY	ITCH	0.3056
p.P1299L	ACH-000894	Lung Cancer	CCLE	PPPY	ITCH	0.7582
p.P1299L	NCI-H1869	lung	COSMIC	PPPY	ITCH	0.7582

Drug responses associated with ERBB4 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G668V (No)	GDSC	CI-1033	625.7219
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G668V (No)	GDSC	PF-00299804	634.8413
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G668V (No)	GDSC	AST-1306	607.8213
SIDM01228	SKCM\|melanoma	p.A1083V (No)	GDSC	CI-1033	0.3935
SIDM01228	SKCM\|melanoma	p.A1083V (No)	GDSC	PF-00299804	0.1643
SIDM01228	SKCM\|melanoma	p.A1083V (No)	GDSC	AST-1306	0.2247
SIDM01228	SKCM\|melanoma	p.C945F (No)	GDSC	CI-1033	0.3935
SIDM01228	SKCM\|melanoma	p.C945F (No)	GDSC	PF-00299804	0.1643
SIDM01228	SKCM\|melanoma	p.C945F (No)	GDSC	AST-1306	0.2247
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G863E (No)	GDSC	CI-1033	1.6259
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G863E (No)	GDSC	PF-00299804	0.9758
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G863E (No)	GDSC	AST-1306	4.8215
SIDM00213	THCA\|thyroid	p.V748L (No)	GDSC	CI-1033	11.7349
SIDM00213	THCA\|thyroid	p.V748L (No)	GDSC	PF-00299804	20.7714
SIDM00213	THCA\|thyroid	p.V748L (No)	GDSC	AST-1306	11.4067
SIDM00680	COREAD\|large_intestine	p.V553E (No)	GDSC	CI-1033	7.6901
SIDM00680	COREAD\|large_intestine	p.V553E (No)	GDSC	PF-00299804	6.6906
SIDM00680	COREAD\|large_intestine	p.V553E (No)	GDSC	AST-1306	8.6121
SIDM00145	ALL\|lymphoblastic_leukemia	p.A287T (No)	GDSC	CI-1033	4.9765
SIDM00145	ALL\|lymphoblastic_leukemia	p.A287T (No)	GDSC	PF-00299804	2.5703
SIDM00145	ALL\|lymphoblastic_leukemia	p.A287T (No)	GDSC	AST-1306	5.3078
SIDM00661	DLBC\|B_cell_lymphoma	p.T639A (No)	GDSC	CI-1033	12.0365
SIDM00661	DLBC\|B_cell_lymphoma	p.T639A (No)	GDSC	PF-00299804	4.0679
SIDM00661	DLBC\|B_cell_lymphoma	p.T639A (No)	GDSC	AST-1306	5.0729
SIDM00683	PRAD\|prostate	p.Q1126* (No)	GDSC	CI-1033	13.1536
SIDM00683	PRAD\|prostate	p.Q1126* (No)	GDSC	PF-00299804	13.0157
SIDM00683	PRAD\|prostate	p.Q1126* (No)	GDSC	AST-1306	27.4993
SIDM00351	HNSC\|head_and_neck	p.G1109C (No)	GDSC	CI-1033	280.2049
SIDM00351	HNSC\|head_and_neck	p.G1109C (No)	GDSC	PF-00299804	172.5797
SIDM00351	HNSC\|head_and_neck	p.G1109C (No)	GDSC	AST-1306	251.9199
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G107V (No)	GDSC	CI-1033	52.3177
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G107V (No)	GDSC	PF-00299804	9.1914
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G107V (No)	GDSC	AST-1306	9.9412
SIDM01007	ALL\|lymphoblastic_leukemia	p.I119T (No)	GDSC	CI-1033	3.0971
SIDM01007	ALL\|lymphoblastic_leukemia	p.I119T (No)	GDSC	PF-00299804	1.6503
SIDM01007	ALL\|lymphoblastic_leukemia	p.I119T (No)	GDSC	AST-1306	3.0199
SIDM00664	PAAD\|pancreas	p.E1090D (No)	GDSC	CI-1033	121.4984
SIDM00664	PAAD\|pancreas	p.E1090D (No)	GDSC	PF-00299804	77.9236
SIDM00664	PAAD\|pancreas	p.E1090D (No)	GDSC	AST-1306	13.6513
SIDM01009	NB\|neuroblastoma	p.P386S (No)	GDSC	CI-1033	5.1399
SIDM01009	NB\|neuroblastoma	p.P386S (No)	GDSC	PF-00299804	2.2239
SIDM01009	NB\|neuroblastoma	p.P386S (No)	GDSC	AST-1306	3.9816
SIDM00214	COREAD\|large_intestine	p.R1250W (No)	GDSC	CI-1033	16.3474
SIDM00214	COREAD\|large_intestine	p.R1250W (No)	GDSC	PF-00299804	16.5693
SIDM00214	COREAD\|large_intestine	p.R1250W (No)	GDSC	AST-1306	13.2789
SIDM01088	UNCLASSIFIED\|endometrium	p.D960Y (No)	GDSC	CI-1033	1.8076
SIDM01088	UNCLASSIFIED\|endometrium	p.D960Y (No)	GDSC	PF-00299804	0.8176
SIDM01088	UNCLASSIFIED\|endometrium	p.D960Y (No)	GDSC	AST-1306	0.4803
SIDM00938	BRCA\|breast	p.M250I (No)	GDSC	CI-1033	3.2379
SIDM00938	BRCA\|breast	p.M250I (No)	GDSC	PF-00299804	8.513
SIDM00938	BRCA\|breast	p.M250I (No)	GDSC	AST-1306	3.0479
SIDM00003	SKCM\|melanoma	p.E317D (No)	GDSC	CI-1033	12.5763
SIDM00003	SKCM\|melanoma	p.E317D (No)	GDSC	PF-00299804	21.7285
SIDM00003	SKCM\|melanoma	p.E317D (No)	GDSC	AST-1306	7.7801
SIDM00551	ESCA\|oesophagus	p.P1058R (No)	GDSC	CI-1033	2.4348
SIDM00551	ESCA\|oesophagus	p.P1058R (No)	GDSC	PF-00299804	1.3046
SIDM00551	ESCA\|oesophagus	p.P1058R (No)	GDSC	AST-1306	2.5895
SIDM01197	COREAD\|large_intestine	p.S227N (No)	GDSC	CI-1033	1228.0969
SIDM01197	COREAD\|large_intestine	p.S227N (No)	GDSC	PF-00299804	118.7014
SIDM01197	COREAD\|large_intestine	p.S227N (No)	GDSC	AST-1306	35.2199
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.L1285P (No)	GDSC	CI-1033	10.5003
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.L1285P (No)	GDSC	PF-00299804	8.0399
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.L1285P (No)	GDSC	AST-1306	7.928
SIDM00619	THCA\|thyroid	p.M562L (No)	GDSC	CI-1033	2.2569
SIDM00619	THCA\|thyroid	p.M562L (No)	GDSC	PF-00299804	1.5015
SIDM00619	THCA\|thyroid	p.M562L (No)	GDSC	AST-1306	0.2762
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R114Q (No)	GDSC	CI-1033	3.9782
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R114Q (No)	GDSC	PF-00299804	4.7819
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R114Q (No)	GDSC	AST-1306	3.6829
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.I827R (No)	GDSC	CI-1033	10.1065
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.I827R (No)	GDSC	PF-00299804	19.2743
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.I827R (No)	GDSC	AST-1306	10.7208
SIDM00333	UCEC\|endometrium	p.A978T (No)	GDSC	CI-1033	9.3187
SIDM00333	UCEC\|endometrium	p.A978T (No)	GDSC	PF-00299804	4.5029
SIDM00333	UCEC\|endometrium	p.A978T (No)	GDSC	AST-1306	4.1386
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.L74H (No)	GDSC	CI-1033	14.0918
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.L74H (No)	GDSC	PF-00299804	2.9404
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.L74H (No)	GDSC	AST-1306	4.7326
SIDM00401	SKCM\|melanoma	p.A4E (No)	GDSC	CI-1033	4.6485
SIDM00401	SKCM\|melanoma	p.A4E (No)	GDSC	PF-00299804	9.6739
SIDM00401	SKCM\|melanoma	p.A4E (No)	GDSC	AST-1306	5.7254
SIDM00600	THCA\|thyroid	p.T716S (No)	GDSC	CI-1033	3.444
SIDM00600	THCA\|thyroid	p.T716S (No)	GDSC	PF-00299804	2.3879
SIDM00600	THCA\|thyroid	p.T716S (No)	GDSC	AST-1306	0.6832
SIDM00489	HNSC\|head_and_neck	p.P854L (No)	GDSC	CI-1033	2.5945
SIDM00489	HNSC\|head_and_neck	p.P854L (No)	GDSC	PF-00299804	7.3201
SIDM00489	HNSC\|head_and_neck	p.P854L (No)	GDSC	AST-1306	0.4299
SIDM00217	COREAD\|large_intestine	p.T1264I (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.T1264I (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.T1264I (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.G1069V (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.G1069V (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.G1069V (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.V667A (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.V667A (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.V667A (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.N403S (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.N403S (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.N403S (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.G338D (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.G338D (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.G338D (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.G223E (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.G223E (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.G223E (No)	GDSC	AST-1306	4.4781
SIDM00140	SKCM\|melanoma	p.G730E (No)	GDSC	CI-1033	4.6509
SIDM00140	SKCM\|melanoma	p.G730E (No)	GDSC	PF-00299804	3.5824
SIDM00140	SKCM\|melanoma	p.G730E (No)	GDSC	AST-1306	3.4539
SIDM00140	SKCM\|melanoma	p.G730R (No)	GDSC	CI-1033	4.6509
SIDM00140	SKCM\|melanoma	p.G730R (No)	GDSC	PF-00299804	3.5824
SIDM00140	SKCM\|melanoma	p.G730R (No)	GDSC	AST-1306	3.4539
SIDM00140	SKCM\|melanoma	p.M313I (No)	GDSC	CI-1033	4.6509
SIDM00140	SKCM\|melanoma	p.M313I (No)	GDSC	PF-00299804	3.5824
SIDM00140	SKCM\|melanoma	p.M313I (No)	GDSC	AST-1306	3.4539
SIDM00323	DLBC\|B_cell_lymphoma	p.P1249S (No)	GDSC	CI-1033	46.2567
SIDM00323	DLBC\|B_cell_lymphoma	p.P1249S (No)	GDSC	PF-00299804	9.5139
SIDM00323	DLBC\|B_cell_lymphoma	p.P1249S (No)	GDSC	AST-1306	6.1981
SIDM00243	UNCLASSIFIED\|testis	p.P1114L (No)	GDSC	CI-1033	2.9011
SIDM00243	UNCLASSIFIED\|testis	p.P1114L (No)	GDSC	PF-00299804	2.3614
SIDM00243	UNCLASSIFIED\|testis	p.P1114L (No)	GDSC	AST-1306	2.6068
SIDM00082	SKCM\|melanoma	p.R50C (No)	GDSC	CI-1033	1.6738
SIDM00082	SKCM\|melanoma	p.R50C (No)	GDSC	PF-00299804	11.8734
SIDM00082	SKCM\|melanoma	p.R50C (No)	GDSC	AST-1306	1.529
SIDM00889	CESC\|cervix	p.L1227M (No)	GDSC	CI-1033	0.9449
SIDM00889	CESC\|cervix	p.L1227M (No)	GDSC	PF-00299804	1.5392
SIDM00889	CESC\|cervix	p.L1227M (No)	GDSC	AST-1306	0.9173
SIDM00889	CESC\|cervix	p.I1226T (No)	GDSC	CI-1033	0.9449
SIDM00889	CESC\|cervix	p.I1226T (No)	GDSC	PF-00299804	1.5392
SIDM00889	CESC\|cervix	p.I1226T (No)	GDSC	AST-1306	0.9173
SIDM00839	COREAD\|large_intestine	p.R782Q (No)	GDSC	CI-1033	2.3204
SIDM00839	COREAD\|large_intestine	p.R782Q (No)	GDSC	PF-00299804	2.0335
SIDM00839	COREAD\|large_intestine	p.R782Q (No)	GDSC	AST-1306	4.1598
SIDM00216	COREAD\|large_intestine	p.R1250W (No)	GDSC	CI-1033	2.15
SIDM00216	COREAD\|large_intestine	p.R1250W (No)	GDSC	PF-00299804	1.4193
SIDM00216	COREAD\|large_intestine	p.R1250W (No)	GDSC	AST-1306	2.2393
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P1299L (Yes)	GDSC	CI-1033	2.1216
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P1299L (Yes)	GDSC	PF-00299804	2.2222
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P1299L (Yes)	GDSC	AST-1306	2.318
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V391I (No)	GDSC	CI-1033	0.7093
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V391I (No)	GDSC	PF-00299804	1.3321
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V391I (No)	GDSC	AST-1306	1.0731
SIDM01096	COREAD\|large_intestine	p.G758C (No)	GDSC	CI-1033	5.474
SIDM01096	COREAD\|large_intestine	p.G758C (No)	GDSC	PF-00299804	4.9215
SIDM01096	COREAD\|large_intestine	p.G758C (No)	GDSC	AST-1306	6.4973
SIDM01096	COREAD\|large_intestine	p.L567F (No)	GDSC	CI-1033	5.474
SIDM01096	COREAD\|large_intestine	p.L567F (No)	GDSC	PF-00299804	4.9215
SIDM01096	COREAD\|large_intestine	p.L567F (No)	GDSC	AST-1306	6.4973
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1083S (No)	GDSC	CI-1033	9.1671
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1083S (No)	GDSC	PF-00299804	3.2101
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1083S (No)	GDSC	AST-1306	2.114
SIDM00596	UCEC\|endometrium	p.L770P (No)	GDSC	CI-1033	8.9198
SIDM00596	UCEC\|endometrium	p.L770P (No)	GDSC	PF-00299804	17.4219
SIDM00596	UCEC\|endometrium	p.L770P (No)	GDSC	AST-1306	13.2253
SIDM00596	UCEC\|endometrium	p.T639M (No)	GDSC	CI-1033	8.9198
SIDM00596	UCEC\|endometrium	p.T639M (No)	GDSC	PF-00299804	17.4219
SIDM00596	UCEC\|endometrium	p.T639M (No)	GDSC	AST-1306	13.2253
SIDM00660	COREAD\|large_intestine	p.M882I (No)	GDSC	CI-1033	35.7038
SIDM00660	COREAD\|large_intestine	p.M882I (No)	GDSC	PF-00299804	7.2388
SIDM00660	COREAD\|large_intestine	p.M882I (No)	GDSC	AST-1306	12.0816
SIDM00660	COREAD\|large_intestine	p.R837G (No)	GDSC	CI-1033	35.7038
SIDM00660	COREAD\|large_intestine	p.R837G (No)	GDSC	PF-00299804	7.2388
SIDM00660	COREAD\|large_intestine	p.R837G (No)	GDSC	AST-1306	12.0816
SIDM00928	BRCA\|breast	p.M1017T (No)	GDSC	CI-1033	4.4545
SIDM00928	BRCA\|breast	p.M1017T (No)	GDSC	PF-00299804	3.6922
SIDM00928	BRCA\|breast	p.M1017T (No)	GDSC	AST-1306	4.0123
SIDM00094	KIRC\|kidney	p.T108fs*14 (No)	GDSC	CI-1033	24.105
SIDM00094	KIRC\|kidney	p.T108fs*14 (No)	GDSC	PF-00299804	8.29
SIDM00094	KIRC\|kidney	p.T108fs*14 (No)	GDSC	AST-1306	4.0648
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.L1247M (No)	GDSC	CI-1033	17.5583
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.L1247M (No)	GDSC	PF-00299804	10.841
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.L1247M (No)	GDSC	AST-1306	8.4474
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.S1246R (No)	GDSC	CI-1033	17.5583
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.S1246R (No)	GDSC	PF-00299804	10.841
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.S1246R (No)	GDSC	AST-1306	8.4474
SIDM00379	GBM\|glioma	p.L538F (No)	GDSC	CI-1033	21.0255
SIDM00379	GBM\|glioma	p.L538F (No)	GDSC	PF-00299804	7.2815
SIDM00379	GBM\|glioma	p.L538F (No)	GDSC	AST-1306	6.6768
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.V1203L (No)	GDSC	CI-1033	13.1189
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.V1203L (No)	GDSC	PF-00299804	10.0964
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.V1203L (No)	GDSC	AST-1306	6.4315
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M951L (No)	GDSC	CI-1033	287.8976
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M951L (No)	GDSC	PF-00299804	36.7024
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M951L (No)	GDSC	AST-1306	106.2904
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.L1207M (No)	GDSC	CI-1033	13.8474
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.L1207M (No)	GDSC	PF-00299804	9.5661
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.L1207M (No)	GDSC	AST-1306	6.8615
SIDM00324	NB\|neuroblastoma	p.Y222* (No)	GDSC	CI-1033	17.1343
SIDM00324	NB\|neuroblastoma	p.Y222* (No)	GDSC	PF-00299804	7.6388
SIDM00324	NB\|neuroblastoma	p.Y222* (No)	GDSC	AST-1306	76.4825
SIDM00150	COREAD\|large_intestine	p.S418fs*2 (No)	GDSC	CI-1033	51.0403
SIDM00150	COREAD\|large_intestine	p.S418fs*2 (No)	GDSC	PF-00299804	15.2578
SIDM00150	COREAD\|large_intestine	p.S418fs*2 (No)	GDSC	AST-1306	23.595
SIDM00413	DLBC\|B_cell_lymphoma	p.V949I (No)	GDSC	CI-1033	45.3419
SIDM00413	DLBC\|B_cell_lymphoma	p.V949I (No)	GDSC	PF-00299804	23.2993
SIDM00413	DLBC\|B_cell_lymphoma	p.V949I (No)	GDSC	AST-1306	176.9086
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.G879* (No)	GDSC	CI-1033	8.2936
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.G879* (No)	GDSC	PF-00299804	4.2259
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.G879* (No)	GDSC	AST-1306	6.282
SIDM00789	COREAD\|large_intestine	p.L369I (No)	GDSC	CI-1033	193.7807
SIDM00789	COREAD\|large_intestine	p.L369I (No)	GDSC	PF-00299804	7.9634
SIDM00789	COREAD\|large_intestine	p.L369I (No)	GDSC	AST-1306	25.9277
SIDM00534	COREAD\|large_intestine	p.R992H (No)	GDSC	CI-1033	1.5327
SIDM00534	COREAD\|large_intestine	p.R992H (No)	GDSC	PF-00299804	1.7431
SIDM00534	COREAD\|large_intestine	p.R992H (No)	GDSC	AST-1306	1.4418
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E810K (No)	GDSC	CI-1033	4.0887
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E810K (No)	GDSC	PF-00299804	21.8673
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E810K (No)	GDSC	AST-1306	19.1221
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E452K (No)	GDSC	CI-1033	4.0887
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E452K (No)	GDSC	PF-00299804	21.8673
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E452K (No)	GDSC	AST-1306	19.1221
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.G31E (No)	GDSC	CI-1033	4.0887
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.G31E (No)	GDSC	PF-00299804	21.8673
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.G31E (No)	GDSC	AST-1306	19.1221
SIDM00487	COREAD\|large_intestine	p.L780P (No)	GDSC	CI-1033	0.1143
SIDM00487	COREAD\|large_intestine	p.L780P (No)	GDSC	PF-00299804	0.0699
SIDM00487	COREAD\|large_intestine	p.L780P (No)	GDSC	AST-1306	0.3311
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.E1100D (No)	GDSC	CI-1033	19.3737
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.E1100D (No)	GDSC	PF-00299804	10.4193
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.E1100D (No)	GDSC	AST-1306	5.2164
SIDM00545	SKCM\|melanoma	p.M766I (No)	GDSC	CI-1033	23.8639
SIDM00545	SKCM\|melanoma	p.M766I (No)	GDSC	PF-00299804	24.0428
SIDM00545	SKCM\|melanoma	p.M766I (No)	GDSC	AST-1306	22.8082
SIDM00545	SKCM\|melanoma	p.S449F (No)	GDSC	CI-1033	23.8639
SIDM00545	SKCM\|melanoma	p.S449F (No)	GDSC	PF-00299804	24.0428
SIDM00545	SKCM\|melanoma	p.S449F (No)	GDSC	AST-1306	22.8082
SIDM00994	ALL\|T_cell_leukemia	p.A17V (No)	GDSC	CI-1033	1.2152
SIDM00994	ALL\|T_cell_leukemia	p.A17V (No)	GDSC	PF-00299804	2.3276
SIDM00994	ALL\|T_cell_leukemia	p.A17V (No)	GDSC	AST-1306	1.9704
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.Y1035H (No)	GDSC	CI-1033	3.2855
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.Y1035H (No)	GDSC	PF-00299804	4.9834
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.Y1035H (No)	GDSC	AST-1306	2.3638
SIDM00290	STAD\|stomach	p.M775I (No)	GDSC	CI-1033	7.3798
SIDM00290	STAD\|stomach	p.M775I (No)	GDSC	PF-00299804	16.2748
SIDM00290	STAD\|stomach	p.M775I (No)	GDSC	AST-1306	11.234
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.E316D (No)	GDSC	CI-1033	4.7495
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.E316D (No)	GDSC	PF-00299804	4.4903
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.E316D (No)	GDSC	AST-1306	5.4567
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A4V (No)	GDSC	CI-1033	4.9793
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A4V (No)	GDSC	PF-00299804	3.0583
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A4V (No)	GDSC	AST-1306	4.9432
SIDM01233	COREAD\|large_intestine	p.T1110P (No)	GDSC	CI-1033	9.915
SIDM01233	COREAD\|large_intestine	p.T1110P (No)	GDSC	PF-00299804	9.1385
SIDM01233	COREAD\|large_intestine	p.T1110P (No)	GDSC	AST-1306	3.873
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P619Q (No)	GDSC	CI-1033	0.679
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P619Q (No)	GDSC	PF-00299804	0.5715
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P619Q (No)	GDSC	AST-1306	0.8778
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.N1193D (No)	GDSC	CI-1033	57.6088
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.N1193D (No)	GDSC	PF-00299804	6.7384
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.N1193D (No)	GDSC	AST-1306	6.1738
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.C467R (No)	GDSC	CI-1033	57.6088
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.C467R (No)	GDSC	PF-00299804	6.7384
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.C467R (No)	GDSC	AST-1306	6.1738
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G816A (No)	GDSC	CI-1033	51.2544
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G816A (No)	GDSC	PF-00299804	29.8756
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G816A (No)	GDSC	AST-1306	11.7866
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G936R (No)	GDSC	CI-1033	189.7676
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G936R (No)	GDSC	PF-00299804	85.3776
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G936R (No)	GDSC	AST-1306	15.4504
SIDM00980	STAD\|stomach	p.D41fs*26 (No)	GDSC	CI-1033	8.2213
SIDM00980	STAD\|stomach	p.D41fs*26 (No)	GDSC	PF-00299804	12.8214
SIDM00980	STAD\|stomach	p.D41fs*26 (No)	GDSC	AST-1306	7.0898
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.M831I (No)	GDSC	CI-1033	7.1168
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.M831I (No)	GDSC	PF-00299804	6.3497
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.M831I (No)	GDSC	AST-1306	3.5929
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.Q826H (No)	GDSC	CI-1033	7.1168
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.Q826H (No)	GDSC	PF-00299804	6.3497
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.Q826H (No)	GDSC	AST-1306	3.5929
SIDM01060	SKCM\|melanoma	p.W171* (No)	GDSC	CI-1033	2.5374
SIDM01060	SKCM\|melanoma	p.W171* (No)	GDSC	PF-00299804	0.3855
SIDM01060	SKCM\|melanoma	p.W171* (No)	GDSC	AST-1306	0.3323
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.A1236V (No)	GDSC	CI-1033	39.6122
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.A1236V (No)	GDSC	PF-00299804	13.0985
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.A1236V (No)	GDSC	AST-1306	10.6559
SIDM00539	ESCA\|oesophagus	p.M772L (No)	GDSC	CI-1033	0.1344
SIDM00539	ESCA\|oesophagus	p.M772L (No)	GDSC	PF-00299804	0.1055
SIDM00539	ESCA\|oesophagus	p.M772L (No)	GDSC	AST-1306	0.1053
SIDM00942	HNSC\|head_and_neck	p.N465K (No)	GDSC	CI-1033	10.9899
SIDM00942	HNSC\|head_and_neck	p.N465K (No)	GDSC	PF-00299804	14.6331
SIDM00942	HNSC\|head_and_neck	p.N465K (No)	GDSC	AST-1306	1.9208
SIDM00581	GBM\|glioma	p.T394S (No)	GDSC	CI-1033	7.1841
SIDM00581	GBM\|glioma	p.T394S (No)	GDSC	PF-00299804	9.4837
SIDM00581	GBM\|glioma	p.T394S (No)	GDSC	AST-1306	3.9102
SIDM01259	ALL\|lymphoblastic_leukemia	p.P1297L (Yes)	GDSC	CI-1033	26.5943
SIDM01259	ALL\|lymphoblastic_leukemia	p.P1297L (Yes)	GDSC	PF-00299804	7.2571
SIDM01259	ALL\|lymphoblastic_leukemia	p.P1297L (Yes)	GDSC	AST-1306	5.7931
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.R524H (No)	GDSC	CI-1033	0.7557
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.R524H (No)	GDSC	PF-00299804	4.3875
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.R524H (No)	GDSC	AST-1306	5.0071
SIDM00148	BRCA\|breast	p.Y1242C (No)	GDSC	CI-1033	7.6005
SIDM00148	BRCA\|breast	p.Y1242C (No)	GDSC	PF-00299804	7.1883
SIDM00148	BRCA\|breast	p.Y1242C (No)	GDSC	AST-1306	6.9505
SIDM01027	ESCA\|oesophagus	p.Q93P (No)	GDSC	CI-1033	0.2481
SIDM01027	ESCA\|oesophagus	p.Q93P (No)	GDSC	PF-00299804	0.5468
SIDM01027	ESCA\|oesophagus	p.Q93P (No)	GDSC	AST-1306	0.4875
SIDM01146	STAD\|stomach	p.G511C (No)	GDSC	CI-1033	2.2418
SIDM01146	STAD\|stomach	p.G511C (No)	GDSC	PF-00299804	1.7179
SIDM01146	STAD\|stomach	p.G511C (No)	GDSC	AST-1306	0.9416
SIDM00837	COREAD\|large_intestine	p.P1196S (No)	GDSC	CI-1033	37.7483
SIDM00837	COREAD\|large_intestine	p.P1196S (No)	GDSC	PF-00299804	47.4842
SIDM00837	COREAD\|large_intestine	p.P1196S (No)	GDSC	AST-1306	9.4265
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D1257E (No)	GDSC	CI-1033	36.8096
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D1257E (No)	GDSC	PF-00299804	18.9073
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D1257E (No)	GDSC	AST-1306	19.9553
SIDM00416	DLBC\|B_cell_lymphoma	p.T194A (No)	GDSC	CI-1033	3.7518
SIDM00416	DLBC\|B_cell_lymphoma	p.T194A (No)	GDSC	PF-00299804	2.5396
SIDM00416	DLBC\|B_cell_lymphoma	p.T194A (No)	GDSC	AST-1306	7.9178
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.E1100V (No)	GDSC	CI-1033	2.9775
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.E1100V (No)	GDSC	PF-00299804	2.9577
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.E1100V (No)	GDSC	AST-1306	3.9355
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.P309S (No)	GDSC	CI-1033	12.2259
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.P309S (No)	GDSC	PF-00299804	10.5608
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.P309S (No)	GDSC	AST-1306	4.613
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G107V (No)	GDSC	CI-1033	12.2259
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G107V (No)	GDSC	PF-00299804	10.5608
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G107V (No)	GDSC	AST-1306	4.613
SIDM00693	BLCA\|bladder	p.R1045G (No)	GDSC	CI-1033	30.452
SIDM00693	BLCA\|bladder	p.R1045G (No)	GDSC	PF-00299804	16.2561
SIDM00693	BLCA\|bladder	p.R1045G (No)	GDSC	AST-1306	12.8772
SIDM00284	SKCM\|melanoma	p.G127E (No)	GDSC	CI-1033	8.4237
SIDM00284	SKCM\|melanoma	p.G127E (No)	GDSC	PF-00299804	22.8686
SIDM00284	SKCM\|melanoma	p.G127E (No)	GDSC	AST-1306	16.8593
SIDM00193	COREAD\|large_intestine	p.R95C (No)	GDSC	CI-1033	6.7985
SIDM00193	COREAD\|large_intestine	p.R95C (No)	GDSC	PF-00299804	9.5939
SIDM00193	COREAD\|large_intestine	p.R95C (No)	GDSC	AST-1306	3.7294
SIDM00118	COREAD\|large_intestine	p.K1002N (No)	GDSC	CI-1033	12.879
SIDM00118	COREAD\|large_intestine	p.K1002N (No)	GDSC	PF-00299804	19.2692
SIDM00118	COREAD\|large_intestine	p.K1002N (No)	GDSC	AST-1306	27.6776
SIDM00118	COREAD\|large_intestine	p.P594Q (No)	GDSC	CI-1033	12.879
SIDM00118	COREAD\|large_intestine	p.P594Q (No)	GDSC	PF-00299804	19.2692
SIDM00118	COREAD\|large_intestine	p.P594Q (No)	GDSC	AST-1306	27.6776
SIDM00118	COREAD\|large_intestine	p.I161M (No)	GDSC	CI-1033	12.879
SIDM00118	COREAD\|large_intestine	p.I161M (No)	GDSC	PF-00299804	19.2692
SIDM00118	COREAD\|large_intestine	p.I161M (No)	GDSC	AST-1306	27.6776
SIDM01248	THCA\|thyroid	p.G1049E (No)	GDSC	CI-1033	8.2727
SIDM01248	THCA\|thyroid	p.G1049E (No)	GDSC	PF-00299804	7.2249
SIDM01248	THCA\|thyroid	p.G1049E (No)	GDSC	AST-1306	7.1822

All proteins holding degron of PPPY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NK58	Putative lipoyltransferase 2, mitochondrial	ITCH	139:142	PPPY	ITCH,NEDD4	0.8475	More...
O00512	B-cell CLL/lymphoma 9 protein	ITCH	515:518	PPPY	ITCH,NEDD4	0.9973	More...
O14559	Rho GTPase-activating protein 33	ITCH	966:969	PPPY	ITCH,NEDD4	0.7553	More...
O14559	Rho GTPase-activating protein 33	ITCH	1267:1270	PPPY	ITCH,NEDD4	0.8377	More...
O14641	Segment polarity protein dishevelled homolog DVL-2	ITCH	565:568	PPPY	ITCH,NEDD4	0.9448	More...
O14669	Transmembrane gamma-carboxyglutamic acid protein 2	ITCH	192:195	PPPY	ITCH,NEDD4	0.9966	More...
O14795	Protein unc-13 homolog B	ITCH	200:203	PPPY	ITCH,NEDD4	0.9976	More...
O15047	Histone-lysine N-methyltransferase SETD1A	ITCH	614:617	PPPY	ITCH,NEDD4	0.9788	More...
O15049	NEDD4-binding protein 3	ITCH	245:248	PPPY	ITCH,NEDD4	0.9279	More...
O15054	Lysine-specific demethylase 6B	ITCH	573:576	PPPY	ITCH,NEDD4	0.7712	More...
O15072	A disintegrin and metalloproteinase with thrombospondin motifs 3	ITCH	1058:1061	PPPY	ITCH,NEDD4	0.9797	More...
O15165	Low-density lipoprotein receptor class A domain-containing protein 4	ITCH	180:183	PPPY	ITCH,NEDD4	0.9111	More...
O15350	Tumor protein p73	ITCH	484:487	PPPY	ITCH,NEDD4	0.6964	More...
O43182	Rho GTPase-activating protein 6	ITCH	881:884	PPPY	ITCH,NEDD4	0.929	More...
O43541	Mothers against decapentaplegic homolog 6	ITCH	276:279	PPPY	ITCH,NEDD4	0.5177	More...
O94850	Dendrin	ITCH	224:227	PPPY	ITCH,NEDD4	0.9946	More...
O95395	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3	ITCH	285:288	PPPY	ITCH,NEDD4	0.5532	More...
O95415	Brain protein I3	ITCH	39:42	PPPY	ITCH,NEDD4	0.9496	More...
O95835	Serine/threonine-protein kinase LATS1	ITCH	373:376	PPPY	ITCH,NEDD4	0.9971	More...
O95835	Serine/threonine-protein kinase LATS1	ITCH	556:559	PPPY	ITCH,NEDD4	0.9214	More...
O96028	Histone-lysine N-methyltransferase NSD2	ITCH	988:991	PPPY	ITCH,NEDD4	0.9082	More...
P02751	Fibronectin	ITCH	302:305	PPPY	ITCH,NEDD4	0.7954	More...
P02814	Submaxillary gland androgen-regulated protein 3B	ITCH	51:54	PPPY	ITCH,NEDD4	0.7998	More...
P05549	Transcription factor AP-2-alpha	ITCH	59:62	PPPY	ITCH,NEDD4	0.9994	More...
P20936	Ras GTPase-activating protein 1	ITCH	139:142	PPPY	ITCH,NEDD4	0.9905	More...
P48634	Protein PRRC2A	ITCH	262:265	PPPY	ITCH,NEDD4	0.5977	More...
P48634	Protein PRRC2A	ITCH	831:834	PPPY	ITCH,NEDD4	0.9976	More...
P54259	Atrophin-1	ITCH	445:448	PPPY	ITCH,NEDD4	0.973	More...
P54259	Atrophin-1	ITCH	636:639	PPPY	ITCH,NEDD4	0.9909	More...
P57082	T-box transcription factor TBX4	ITCH	370:373	PPPY	ITCH,NEDD4	0.9887	More...
P98153	Integral membrane protein DGCR2/IDD	ITCH	430:433	PPPY	ITCH,NEDD4	0.923	More...
P98153	Integral membrane protein DGCR2/IDD	ITCH	448:451	PPPY	ITCH,NEDD4	0.7303	More...
Q01196	Runt-related transcription factor 1	ITCH	355:358	PPPY	ITCH,NEDD4	0.9852	More...
Q06416	Putative POU domain, class 5, transcription factor 1B	ITCH	64:67	PPPY	ITCH,NEDD4	0.6899	More...
Q08345	Epithelial discoidin domain-containing receptor 1	ITCH	481:484	PPPY	ITCH,NEDD4	0.9509	More...
Q12951	Forkhead box protein I1	ITCH	72:75	PPPY	ITCH,NEDD4	0.6272	More...
Q13017	Rho GTPase-activating protein 5	ITCH	988:991	PPPY	ITCH,NEDD4	0.9581	More...
Q13480	GRB2-associated-binding protein 1	ITCH	159:162	PPPY	ITCH,NEDD4	0.9888	More...
Q13571	Lysosomal-associated transmembrane protein 5	ITCH	256:259	PPPY	ITCH,NEDD4	0.8015	More...
Q13573	SNW domain-containing protein 1	ITCH	41:44	PPPY	ITCH,NEDD4	0.999	More...
Q13625	Apoptosis-stimulating of p53 protein 2	ITCH	871:874	PPPY	ITCH,NEDD4	0.9885	More...
Q13635	Protein patched homolog 1	ITCH	1313:1316	PPPY	ITCH,NEDD4	0.9833	More...
Q13761	Runt-related transcription factor 3	ITCH	309:312	PPPY	ITCH,NEDD4	0.9935	More...
Q13950	Runt-related transcription factor 2	ITCH	423:426	PPPY	ITCH,NEDD4	0.9888	More...
Q14112	Nidogen-2	ITCH	411:414	PPPY	ITCH,NEDD4	0.9797	More...
Q14118	Dystroglycan 1	ITCH	889:892	PPPY	ITCH,NEDD4	0.9988	More...
Q14151	Scaffold attachment factor B2	ITCH	943:946	PPPY	ITCH,NEDD4	0.9012	More...
Q14686	Nuclear receptor coactivator 6	ITCH	373:376	PPPY	ITCH,NEDD4	0.9837	More...
Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	ITCH	51:54	PPPY	ITCH,NEDD4	0.9539	More...
Q15012	Lysosomal-associated transmembrane protein 4A	ITCH	227:230	PPPY	ITCH,NEDD4	0.8271	More...
Q15018	BRISC complex subunit Abraxas 2	ITCH	305:308	PPPY	ITCH,NEDD4	0.9939	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	ITCH	1298:1301	PPPY	ITCH,NEDD4	0.9446	More...
Q15427	Splicing factor 3B subunit 4	ITCH	391:394	PPPY	ITCH,NEDD4	0.9915	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	ITCH	567:570	PPPY	ITCH,NEDD4	0.9991	More...
Q16534	Hepatic leukemia factor	ITCH	16:19	PPPY	ITCH,NEDD4	0.8832	More...
Q16621	Transcription factor NF-E2 45 kDa subunit	ITCH	80:83	PPPY	ITCH,NEDD4	0.9539	More...
Q16625	Occludin	ITCH	9:12	PPPY	ITCH,NEDD4	0.8621	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	ITCH	387:390	PPPY	ITCH,NEDD4	0.9919	More...
Q16655	Melanoma antigen recognized by T-cells 1	ITCH	113:116	PPPY	ITCH,NEDD4	0.8685	More...
Q16825	Tyrosine-protein phosphatase non-receptor type 21	ITCH	566:569	PPPY	ITCH,NEDD4	0.9701	More...
Q5JU85	IQ motif and SEC7 domain-containing protein 2	ITCH	1279:1282	PPPY	ITCH,NEDD4	0.5604	More...
Q6GQQ9	OTU domain-containing protein 7B	ITCH	766:769	PPPY	ITCH,NEDD4	0.95	More...
Q6UUV7	CREB-regulated transcription coactivator 3	ITCH	445:448	PPPY	ITCH,NEDD4	0.998	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	ITCH	647:650	PPPY	ITCH,NEDD4	0.8809	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	ITCH	803:806	PPPY	ITCH,NEDD4	0.9637	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	ITCH	1117:1120	PPPY	ITCH,NEDD4	0.9484	More...
Q86T03	Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	ITCH	65:68	PPPY	ITCH,NEDD4	0.9965	More...
Q86U86	Protein polybromo-1	ITCH	1572:1575	PPPY	ITCH,NEDD4	0.9838	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	ITCH	561:564	PPPY	ITCH,NEDD4	0.9923	More...
Q86UU5	Gametogenetin	ITCH	338:341	PPPY	ITCH,NEDD4	0.9878	More...
Q86X29	Lipolysis-stimulated lipoprotein receptor	ITCH	620:623	PPPY	ITCH,NEDD4	0.9992	More...
Q86YD5	Low-density lipoprotein receptor class A domain-containing protein 3	ITCH	275:278	PPPY	ITCH,NEDD4	0.997	More...
Q8IV31	Transmembrane protein 139	ITCH	111:114	PPPY	ITCH,NEDD4	0.9962	More...
Q8N1I0	Dedicator of cytokinesis protein 4	ITCH	1900:1903	PPPY	ITCH,NEDD4	0.9993	More...
Q8N448	Ligand of Numb protein X 2	ITCH	445:448	PPPY	ITCH,NEDD4	0.9565	More...
Q8N4L2	Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	ITCH	39:42	PPPY	ITCH,NEDD4	0.9985	More...
Q8NB59	Synaptotagmin-14	ITCH	165:168	PPPY	ITCH,NEDD4	0.9976	More...
Q8NBF1	Zinc finger protein GLIS1	ITCH	165:168	PPPY	ITCH,NEDD4	0.9994	More...
Q8NEA6	Zinc finger protein GLIS3	ITCH	304:307	PPPY	ITCH,NEDD4	0.5841	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	ITCH	2436:2439	PPPY	ITCH,NEDD4	0.986	More...
Q8NI35	InaD-like protein	ITCH	1202:1205	PPPY	ITCH,NEDD4	0.9952	More...
Q8TB68	Proline-rich protein 7	ITCH	163:166	PPPY	ITCH,NEDD4	0.8954	More...
Q8TEB9	Rhomboid-related protein 4	ITCH	292:295	PPPY	ITCH,NEDD4	0.9941	More...
Q8TF74	WAS/WASL-interacting protein family member 2	ITCH	252:255	PPPY	ITCH,NEDD4	0.9988	More...
Q8TF74	WAS/WASL-interacting protein family member 2	ITCH	343:346	PPPY	ITCH,NEDD4	0.9981	More...
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	ITCH	704:707	PPPY	ITCH,NEDD4	0.9478	More...
Q8WXX7	Autism susceptibility gene 2 protein	ITCH	516:519	PPPY	ITCH,NEDD4	0.9979	More...
Q92481	Transcription factor AP-2-beta	ITCH	71:74	PPPY	ITCH,NEDD4	0.9974	More...
Q92567	Protein FAM168A	ITCH	120:123	PPPY	ITCH,NEDD4	0.5413	More...
Q92574	Hamartin	ITCH	601:604	PPPY	ITCH,NEDD4	0.9978	More...
Q92754	Transcription factor AP-2 gamma	ITCH	56:59	PPPY	ITCH,NEDD4	0.997	More...
Q92754	Transcription factor AP-2 gamma	ITCH	61:64	PPPY	ITCH,NEDD4	0.9784	More...
Q92922	SWI/SNF complex subunit SMARCC1	ITCH	996:999	PPPY	ITCH,NEDD4	0.8735	More...
Q969F2	Protein naked cuticle homolog 2	ITCH	377:380	PPPY	ITCH,NEDD4	0.8617	More...
Q969T9	WW domain-binding protein 2	ITCH	197:200	PPPY	ITCH,NEDD4	0.8658	More...
Q969T9	WW domain-binding protein 2	ITCH	249:252	PPPY	ITCH,NEDD4	0.8392	More...
Q969W9	Protein TMEPAI	ITCH	158:161	PPPY	ITCH,NEDD4	0.866	More...
Q969X1	Protein lifeguard 3	ITCH	7:10	PPPY	ITCH,NEDD4	0.9981	More...
Q96AW1	Vesicular, overexpressed in cancer, prosurvival protein 1	ITCH	162:165	PPPY	ITCH,NEDD4	0.8528	More...
Q96CS7	Pleckstrin homology domain-containing family B member 2	ITCH	129:132	PPPY	ITCH,NEDD4	0.9875	More...
Q96DF8	Splicing factor ESS-2 homolog	ITCH	99:102	PPPY	ITCH,NEDD4	0.9959	More...
Q96DV4	39S ribosomal protein L38, mitochondrial	ITCH	347:350	PPPY	ITCH,NEDD4	0.6466	More...
Q96HA8	Protein N-terminal glutamine amidohydrolase	ITCH	160:163	PPPY	ITCH,NEDD4	0.832	More...
Q96JG9	Zinc finger protein 469	ITCH	709:712	PPPY	ITCH,NEDD4	0.9932	More...
Q96KN3	Homeobox protein PKNOX2	ITCH	21:24	PPPY	ITCH,NEDD4	0.9792	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	ITCH	1867:1870	PPPY	ITCH,NEDD4	0.9381	More...
Q96PK6	RNA-binding protein 14	ITCH	573:576	PPPY	ITCH,NEDD4	0.9849	More...
Q96SZ6	Mitochondrial tRNA methylthiotransferase CDK5RAP1	ITCH	86:89	PPPY	ITCH,NEDD4	0.9857	More...
Q96T58	Msx2-interacting protein	ITCH	2236:2239	PPPY	ITCH,NEDD4	0.9808	More...
Q99935	Opiorphin prepropeptide	ITCH	50:53	PPPY	ITCH,NEDD4	0.9027	More...
Q99946	Proline-rich transmembrane protein 1	ITCH	17:20	PPPY	ITCH,NEDD4	0.9917	More...
Q9BT67	NEDD4 family-interacting protein 1	ITCH	39:42	PPPY	ITCH,NEDD4	0.9967	More...
Q9BTC0	Death-inducer obliterator 1	ITCH	1817:1820	PPPY	ITCH,NEDD4	0.9967	More...
Q9BZ95	Histone-lysine N-methyltransferase NSD3	ITCH	1070:1073	PPPY	ITCH,NEDD4	0.6146	More...
Q9BZD6	Transmembrane gamma-carboxyglutamic acid protein 4	ITCH	204:207	PPPY	ITCH,NEDD4	0.8437	More...
Q9BZJ3	Tryptase delta	ITCH	177:180	PPPY	ITCH,NEDD4	0.5629	More...
Q9GZV9	Fibroblast growth factor 23	ITCH	151:154	PPPY	ITCH,NEDD4	0.9815	More...
Q9H0F5	E3 ubiquitin-protein ligase RNF38	ITCH	381:384	PPPY	ITCH,NEDD4	0.9052	More...
Q9H2G4	Testis-specific Y-encoded-like protein 2	ITCH	73:76	PPPY	ITCH,NEDD4	0.7605	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9945	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	51:54	PPPY	ITCH,NEDD4	0.9943	More...
Q9H3D4	Tumor protein 63	ITCH	540:543	PPPY	ITCH,NEDD4	0.9417	More...
Q9HCM1	Retroelement silencing factor 1	ITCH	279:282	PPPY	ITCH,NEDD4	0.9514	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	ITCH	963:966	PPPY	ITCH,NEDD4	0.9689	More...
Q9NQC3	Reticulon-4	ITCH	656:659	PPPY	ITCH,NEDD4	0.9958	More...
Q9NRJ4	Tubby-related protein 4	ITCH	834:837	PPPY	ITCH,NEDD4	0.9893	More...
Q9NRJ4	Tubby-related protein 4	ITCH	958:961	PPPY	ITCH,NEDD4	0.9994	More...
Q9NRJ4	Tubby-related protein 4	ITCH	1119:1122	PPPY	ITCH,NEDD4	0.989	More...
Q9NRM7	Serine/threonine-protein kinase LATS2	ITCH	515:518	PPPY	ITCH,NEDD4	0.9941	More...
Q9NRR2	Tryptase gamma	ITCH	174:177	PPPY	ITCH,NEDD4	0.5927	More...
Q9NRY6	Phospholipid scramblase 3	ITCH	15:18	PPPY	ITCH,NEDD4	0.9037	More...
Q9NV92	NEDD4 family-interacting protein 2	ITCH	148:151	PPPY	ITCH,NEDD4	0.9623	More...
Q9NV92	NEDD4 family-interacting protein 2	ITCH	174:177	PPPY	ITCH,NEDD4	0.9994	More...
Q9NX94	WW domain binding protein 1-like	ITCH	119:122	PPPY	ITCH,NEDD4	0.9937	More...
Q9NYG2	Palmitoyltransferase ZDHHC3	ITCH	26:29	PPPY	ITCH,NEDD4	0.669	More...
Q9NZ81	Proline-rich protein 13	ITCH	78:81	PPPY	ITCH,NEDD4	0.9396	More...
Q9UIS9	Methyl-CpG-binding domain protein 1	ITCH	400:403	PPPY	ITCH,NEDD4	0.7098	More...
Q9UKN5	PR domain zinc finger protein 4	ITCH	94:97	PPPY	ITCH,NEDD4	0.6746	More...
Q9UM47	Neurogenic locus notch homolog protein 3	ITCH	2208:2211	PPPY	ITCH,NEDD4	0.8622	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	ITCH	2292:2295	PPPY	ITCH,NEDD4	0.9949	More...
Q9UMS6	Synaptopodin-2	ITCH	619:622	PPPY	ITCH,NEDD4	0.9793	More...
Q9UPP2	IQ motif and SEC7 domain-containing protein 3	ITCH	1153:1156	PPPY	ITCH,NEDD4	0.8368	More...
Q9UPW8	Protein unc-13 homolog A	ITCH	210:213	PPPY	ITCH,NEDD4	0.9992	More...
Q9UPZ9	Serine/threonine-protein kinase ICK	ITCH	313:316	PPPY	ITCH,NEDD4	0.9808	More...
Q9Y3C5	RING finger protein 11	ITCH	37:40	PPPY	ITCH,NEDD4	0.9962	More...
Q9Y5W3	Krueppel-like factor 2	ITCH	81:84	PPPY	ITCH,NEDD4	0.9881	More...
Q9Y6W3	Calpain-7	ITCH	624:627	PPPY	ITCH,NEDD4	0.5393	More...
A0PJX4	Protein shisa-3 homolog	ITCH	193:196	PPPY	ITCH,NEDD4	0.9853	More...
P81408	Protein FAM189B	ITCH	247:250	PPPY	ITCH,NEDD4	0.9784	More...
Q6UWW9	Transmembrane protein 207	ITCH	136:139	PPPY	ITCH,NEDD4	0.8536	More...
Q6VUC0	Transcription factor AP-2-epsilon	ITCH	56:59	PPPY	ITCH,NEDD4	0.9747	More...
Q8WUU8	Transmembrane protein 174	ITCH	232:235	PPPY	ITCH,NEDD4	0.8353	More...
Q96DD7	Protein shisa-4	ITCH	184:187	PPPY	ITCH,NEDD4	0.9835	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	113:116	PPPY	ITCH,NEDD4	0.9396	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	129:132	PPPY	ITCH,NEDD4	0.9428	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	145:148	PPPY	ITCH,NEDD4	0.9794	More...
Q99954	Submaxillary gland androgen-regulated protein 3A	ITCH	55:58	PPPY	ITCH,NEDD4	0.8844	More...
Q99954	Submaxillary gland androgen-regulated protein 3A	ITCH	81:84	PPPY	ITCH,NEDD4	0.5816	More...
Q99954	Submaxillary gland androgen-regulated protein 3A	ITCH	95:98	PPPY	ITCH,NEDD4	0.9262	More...
Q9P203	BTB/POZ domain-containing protein 7	ITCH	762:765	PPPY	ITCH,NEDD4	0.9575	More...
Q9P242	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2	ITCH	454:457	PPPY	ITCH,NEDD4	0.9992	More...
O60320	Protein FAM189A1	ITCH	246:249	PPPY	ITCH,NEDD4	0.9766	More...
O60320	Protein FAM189A1	ITCH	295:298	PPPY	ITCH,NEDD4	0.5238	More...
Q15884	Protein FAM189A2	ITCH	194:197	PPPY	ITCH,NEDD4	0.9938	More...
Q3B7T3	Protein BEAN1	ITCH	166:169	PPPY	ITCH,NEDD4	0.9146	More...
Q5JRV8	Transmembrane protein 255A	ITCH	344:347	PPPY	ITCH,NEDD4	0.6405	More...
Q6UXU6	Transmembrane protein 92	ITCH	117:120	PPPY	ITCH,NEDD4	0.54	More...
Q6UXU6	Transmembrane protein 92	ITCH	137:140	PPPY	ITCH,NEDD4	0.5673	More...
Q7L0R7	RING finger protein 44	ITCH	297:300	PPPY	ITCH,NEDD4	0.8077	More...
Q86YQ8	Copine-8	ITCH	550:553	PPPY	ITCH,NEDD4	0.743	More...
Q8IW70	Transmembrane protein 151B	ITCH	527:530	PPPY	ITCH,NEDD4	0.9917	More...
Q8WV15	Transmembrane protein 255B	ITCH	321:324	PPPY	ITCH,NEDD4	0.9864	More...
Q8WVE6	Transmembrane protein 171	ITCH	224:227	PPPY	ITCH,NEDD4	0.991	More...
Q8WXE0	Caskin-2	ITCH	751:754	PPPY	ITCH,NEDD4	0.6879	More...
Q96G27	WW domain-binding protein 1	ITCH	138:141	PPPY	ITCH,NEDD4	0.8782	More...
Q9H0R4	Haloacid dehalogenase-like hydrolase domain-containing protein 2	ITCH	238:241	PPPY	ITCH,NEDD4	0.9907	More...
Q9H1C7	Cysteine-rich and transmembrane domain-containing protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9391	More...
A4D263	Spermatogenesis-associated protein 48	ITCH	85:88	PPPY	ITCH,NEDD4	0.8985	More...
Q86XN7	Proline and serine-rich protein 1	ITCH	233:236	PPPY	ITCH,NEDD4	0.9855	More...
Q8IXP5	Uncharacterized protein C11orf53	ITCH	179:182	PPPY	ITCH,NEDD4	0.9512	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPPY

Degron related mutations and impact score

Drug responses associated with ERBB4 mutations

All proteins holding degron of PPPY