DegronMD - Q96KN3(PKNOX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q25K	TCGA-3B-A9I3	SARC	TCGA	PPPY	ITCH	21:24	Mutation rewiring degron network	0.3056
p.Q25K	DO219942	SARC	ICGC	PPPY	ITCH	21:24	Mutation rewiring degron network	0.3056
p.A359D	TCGA-44-2656	LUAD	TCGA	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1111
p.A359D	DO26052	LUAD	ICGC	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1111
p.F339Y	TCGA-55-8507	LUAD	TCGA	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.2222
p.F339Y	DO45412	LUAD	ICGC	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.2222
p.D357Y	TCGA-55-A48X	LUAD	TCGA	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1667
p.D357Y	DO24048	LUAD	ICGC	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1667
p.M13I	TCGA-61-2002	OV	TCGA	PPPY	ITCH	21:24	Mutation rewiring degron network	0.1111
p.M13I	DO27994	OV	ICGC	PPPY	ITCH	21:24	Mutation rewiring degron network	0.1111
p.M350T	TCGA-AA-3510	COAD	TCGA	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7423
p.M350T	DO7783	COAD	ICGC	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7423
p.Q17H	TCGA-BS-A0UF	UCEC	TCGA	PPPY	ITCH	21:24	Mutation rewiring degron network	0.2222
p.Q17H	DO41488	UCEC	ICGC	PPPY	ITCH	21:24	Mutation rewiring degron network	0.2222
p.M13T	TCGA-CK-4951	COAD	TCGA	PPPY	ITCH	21:24	Mutation rewiring degron network	0.1111
p.M13T	DO10582	COAD	ICGC	PPPY	ITCH	21:24	Mutation rewiring degron network	0.1111
p.P23L	TCGA-EE-A3AG	SKCM	TCGA	PPPY	ITCH	21:24	Mutation altering degron motif	0.6471
p.P23L	DO37471	SKCM	ICGC	PPPY	ITCH	21:24	Mutation altering degron motif	0.6471
p.P23L	SIDM00007	Other Solid Cancers	GDSC	PPPY	ITCH	21:24	Mutation altering degron motif	0.6471
p.P23L	ACH-001550	Skin Cancer	CCLE	PPPY	ITCH	21:24	Mutation altering degron motif	0.6471
p.P23L	MCC13	skin	COSMIC	PPPY	ITCH	21:24	Mutation altering degron motif	0.6471
p.L333M	TCGA-FS-A1ZP	SKCM	TCGA	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0556
p.L333M	DO37703	SKCM	ICGC	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0556
p.D352H	TCGA-LD-A74U	BRCA	TCGA	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.3056
p.D352H	DO49025	BRCA	ICGC	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.3056
p.A15T	TCGA-XK-AAIW	PRAD	TCGA	PPPY	ITCH	21:24	Mutation rewiring degron network	0.1667
p.A15T	DO51407	PRAD	ICGC	PPPY	ITCH	21:24	Mutation rewiring degron network	0.1667
p.P349L	DO220885	MELA	ICGC	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.6471
p.T31R	DO30750	OV	ICGC	PPPY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.R345C	SIDM02061	Esophageal Carcinoma	GDSC	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.719
p.S27N	SIDM00777	Colorectal Carcinoma	GDSC	PPPY	ITCH	21:24	Mutation rewiring degron network	0.25
p.S27N	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPPY	ITCH	21:24	Mutation rewiring degron network	0.25
p.L11M	SIDM00217	Colorectal Carcinoma	GDSC	PPPY	ITCH	21:24	Mutation rewiring degron network	0.0556
p.L11M	ACH-000999	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	21:24	Mutation rewiring degron network	0.0556
p.L11M	SNU-1040	large intestine	COSMIC	PPPY	ITCH	21:24	Mutation rewiring degron network	0.0556
p.R343Q	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.6218
p.R343Q	ACH-000140	Lymphoma	CCLE	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.6218
p.N18K	SIDM01387	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	21:24	Mutation rewiring degron network	0.25
p.N18K	ACH-000921	Lung Cancer	CCLE	PPPY	ITCH	21:24	Mutation rewiring degron network	0.25
p.P349R	ACH-000966	Ovarian Cancer	CCLE	RRRILQPML	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.6401
p.T31K	ACH-001456	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	21:24	Mutation rewiring degron network	0.1389

Kaplan plot for PKNOX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKNOX2

UniProt ID: Q96KN3

Entrez ID: 63876

Protein name: Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKNOX2 in