DegronMD

Uniprot ID: Q96KN3

Source protein: Homeobox protein PKNOX2

Source gene: PKNOX2

Class: DEG_APCC_DBOX_1

Location: 343:351

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5766

ASA_SCORE: 88.3222

COIL: 0.5063

CONS_SCORE: 0.5495

DSS_SCORE: 0.3642

HELIX: 0.4588

FCONS_SCORE: 1.2357

RIG_SCORE: 0.8057

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A359D	TCGA-44-2656	LUAD	TCGA	RRRILQPML	DEG_APCC_DBOX_1	0.1111
p.A359D	DO26052	LUAD	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.1111
p.F339Y	TCGA-55-8507	LUAD	TCGA	RRRILQPML	DEG_APCC_DBOX_1	0.2222
p.F339Y	DO45412	LUAD	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.2222
p.D357Y	TCGA-55-A48X	LUAD	TCGA	RRRILQPML	DEG_APCC_DBOX_1	0.1667
p.D357Y	DO24048	LUAD	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.1667
p.M350T	TCGA-AA-3510	COAD	TCGA	RRRILQPML	DEG_APCC_DBOX_1	0.7423
p.M350T	DO7783	COAD	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.7423
p.L333M	TCGA-FS-A1ZP	SKCM	TCGA	RRRILQPML	DEG_APCC_DBOX_1	0.0556
p.L333M	DO37703	SKCM	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.0556
p.D352H	TCGA-LD-A74U	BRCA	TCGA	RRRILQPML	DEG_APCC_DBOX_1	0.3056
p.D352H	DO49025	BRCA	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.3056
p.P349L	DO220885	MELA	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.6471
p.R345C	SIDM02061	Esophageal Carcinoma	GDSC	RRRILQPML	DEG_APCC_DBOX_1	0.719
p.R343Q	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRRILQPML	DEG_APCC_DBOX_1	0.6218
p.R343Q	ACH-000140	Lymphoma	CCLE	RRRILQPML	DEG_APCC_DBOX_1	0.6218
p.P349R	ACH-000966	Ovarian Cancer	CCLE	RRRILQPML	DEG_APCC_DBOX_1	0.6401

DegronMD: protein-targeted degradation, mutation and drug response to degrons