DegronMD

Uniprot ID: P55347

Source protein: Homeobox protein PKNOX1

Source gene: PKNOX1

Class: DEG_APCC_DBOX_1

Location: 314:322

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7494

ASA_SCORE: 96.8

COIL: 0.562

CONS_SCORE: 0.6706

DSS_SCORE: 0.3245

HELIX: 0.4011

FCONS_SCORE: 1.1542

RIG_SCORE: 0.8141

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I311F	TCGA-B0-5096	KIRC	TCGA	RRRILQPML	DEG_APCC_DBOX_1	0.25
p.I311F	DO19218	KIRC	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.25
p.W309G	TCGA-DU-6392	LGG	TCGA	RRRILQPML	DEG_APCC_DBOX_1	0.1944
p.R316Q	TCGA-EY-A1GI	UCEC	TCGA	RRRILQPML	DEG_APCC_DBOX_1	0.6218
p.R316Q	DO222762	COCA	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.6218
p.R316Q	DO41211	UCEC	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.6218
p.N312D	DO233908	GACA	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.2778
p.M321I	DO228952	LICA	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.6507
p.A313S	DO228976	LICA	ICGC	RRRILQPML	DEG_APCC_DBOX_1	0.3056
p.F310L	SIDM00193	Colorectal Carcinoma	GDSC	RRRILQPML	DEG_APCC_DBOX_1	0.2222
p.F310L	ACH-000991	Colon/Colorectal Cancer	CCLE	RRRILQPML	DEG_APCC_DBOX_1	0.2222
p.F310L	SNU-81	large_intestine	COSMIC	RRRILQPML	DEG_APCC_DBOX_1	0.2222
p.M321V	ACH-000993	Endometrial/Uterine Cancer	CCLE	RRRILQPML	DEG_APCC_DBOX_1	0.6097
p.S324L	ACH-001148	Lymphoma	CCLE	RRRILQPML	DEG_APCC_DBOX_1	0.7222

DegronMD: protein-targeted degradation, mutation and drug response to degrons