DegronMD - Q8WXE0(CASKIN2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S764C	TCGA-12-5299	GBM	TCGA	PPPY	ITCH	751:754	Mutation rewiring degron network	0.0556
p.S764C	DO13330	GBM	ICGC	PPPY	ITCH	751:754	Mutation rewiring degron network	0.0556
p.A1014V	TCGA-AX-A2HD	UCEC	TCGA	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.0833
p.A1014V	DO42608	UCEC	ICGC	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.0833
p.P1039A	TCGA-BT-A42C	BLCA	TCGA	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.0833
p.P1039A	DO49725	BLCA	ICGC	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.0833
p.P747L	TCGA-D3-A8GB	SKCM	TCGA	PPPY	ITCH	751:754	Mutation rewiring degron network	0.2222
p.P747L	DO50280	SKCM	ICGC	PPPY	ITCH	751:754	Mutation rewiring degron network	0.2222
p.A1020T	TCGA-DF-A2KN	UCEC	TCGA	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.25
p.A1020T	DO223282	UCEC	ICGC	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.25
p.P752T	TCGA-EE-A3AB	SKCM	TCGA	PPPY	ITCH	751:754	Mutation altering degron motif	0.7031
p.P752T	DO228952	LICA	ICGC	PPPY	ITCH	751:754	Mutation altering degron motif	0.7031
p.P752T	DO38057	SKCM	ICGC	PPPY	ITCH	751:754	Mutation altering degron motif	0.7031
p.E1040K	TCGA-EY-A1GI	UCEC	TCGA	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.0556
p.E1040K	TCGA-FD-A3SL	BLCA	TCGA	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.0556
p.E1040K	DO732	BLCA	ICGC	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.0556
p.E1040K	DO41211	UCEC	ICGC	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.0556
p.E1040K	SIDM00501	Oral Cavity Carcinoma	GDSC	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.0556
p.E1040K	ACH-001332	Head and Neck Cancer	CCLE	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.0556
p.E1040K	BICR78	upper aerodigestive tract	COSMIC	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.0556
p.P752Q	DO229037	LICA	ICGC	PPPY	ITCH	751:754	Mutation altering degron motif	0.7035
p.A1038E	DO229045	LICA	ICGC	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.1111
p.L1022P	DO67028	THCA	ICGC	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation rewiring degron network	0.3056
p.Y758C	DO43514	UCEC	ICGC	PPPY	ITCH	751:754	Mutation rewiring degron network	0.2222
p.Q1029R	DO42512	UCEC	ICGC	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation altering degron motif	0.7329
p.S744F	SIDM00120	Prostate Carcinoma	GDSC	PPPY	ITCH	751:754	Mutation rewiring degron network	0.1389
p.S744F	ACH-000979	Prostate Cancer	CCLE	PPPY	ITCH	751:754	Mutation rewiring degron network	0.1389
p.R750Q	UMC-11	lung	COSMIC	PPPY	ITCH	751:754	Mutation rewiring degron network	0.3056
p.S1024L	HT-115	large intestine	COSMIC	PSPTPGES	DEG_SCF_FBW7_1	1023:1030	Mutation altering degron motif	0.6556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASKIN2

UniProt ID: Q8WXE0

Entrez ID: 57513

Protein name: Caskin-2 (CASK-interacting protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CASKIN2 in