DegronMD

Uniprot ID: Q8WXE0

Source protein: Caskin-2

Source gene: CASKIN2

Class: DEG_SCF_FBW7_1

Location: 1023:1030

E3 ligase: FBXW7

DEGRON score: 0.8292

ASA_SCORE: 92.5125

COIL: 0.9718

CONS_SCORE: 0.3719

DSS_SCORE: 0.7895

HELIX: 0.0124

FCONS_SCORE: 0.9294

RIG_SCORE: 0.4873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1014V	TCGA-AX-A2HD	UCEC	TCGA	PSPTPGES	DEG_SCF_FBW7_1	0.0833
p.A1014V	DO42608	UCEC	ICGC	PSPTPGES	DEG_SCF_FBW7_1	0.0833
p.P1039A	TCGA-BT-A42C	BLCA	TCGA	PSPTPGES	DEG_SCF_FBW7_1	0.0833
p.P1039A	DO49725	BLCA	ICGC	PSPTPGES	DEG_SCF_FBW7_1	0.0833
p.A1020T	TCGA-DF-A2KN	UCEC	TCGA	PSPTPGES	DEG_SCF_FBW7_1	0.25
p.A1020T	DO223282	UCEC	ICGC	PSPTPGES	DEG_SCF_FBW7_1	0.25
p.E1040K	TCGA-EY-A1GI	UCEC	TCGA	PSPTPGES	DEG_SCF_FBW7_1	0.0556
p.E1040K	TCGA-FD-A3SL	BLCA	TCGA	PSPTPGES	DEG_SCF_FBW7_1	0.0556
p.E1040K	DO732	BLCA	ICGC	PSPTPGES	DEG_SCF_FBW7_1	0.0556
p.E1040K	DO41211	UCEC	ICGC	PSPTPGES	DEG_SCF_FBW7_1	0.0556
p.E1040K	SIDM00501	Oral Cavity Carcinoma	GDSC	PSPTPGES	DEG_SCF_FBW7_1	0.0556
p.E1040K	ACH-001332	Head and Neck Cancer	CCLE	PSPTPGES	DEG_SCF_FBW7_1	0.0556
p.E1040K	BICR78	upper_aerodigestive_tract	COSMIC	PSPTPGES	DEG_SCF_FBW7_1	0.0556
p.A1038E	DO229045	LICA	ICGC	PSPTPGES	DEG_SCF_FBW7_1	0.1111
p.L1022P	DO67028	THCA	ICGC	PSPTPGES	DEG_SCF_FBW7_1	0.3056
p.Q1029R	DO42512	UCEC	ICGC	PSPTPGES	DEG_SCF_FBW7_1	0.7329
p.S1024L	HT-115	large_intestine	COSMIC	PSPTPGES	DEG_SCF_FBW7_1	0.6556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXE0	Caskin-2	DEG_SCF_FBW7_1	1023:1030	PSPTPGES	FBXW7	0.8292	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons