DegronMD - Q969T9(WBP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A221T	TCGA-78-8640	LUAD	TCGA	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.3056
p.A224T	TCGA-CD-8529	STAD	TCGA	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.A224T	DO49095	COAD	ICGC	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.A224T	SIDM01608	Endometrial Carcinoma	GDSC	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.P198Q	TCGA-EE-A3AG	SKCM	TCGA	PPPY	ITCH	197:200	Mutation altering degron motif	0.7035
p.P217S	TCGA-GN-A266	SKCM	TCGA	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.6752
p.A228T	TCGA-NH-A5IV	COAD	TCGA	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.1111
p.P214L	TCGA-QB-A6FS	SKCM	TCGA	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.6471
p.A217D	DO228974	LICA	ICGC	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.7793
p.S241R	DO229045	LICA	ICGC	PPPY	ITCH	249:252	Mutation blocking phosphorylation signal	0.5556
p.A217T	DO45340	LUAD	ICGC	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.7139
p.P210L	DO48654	SKCM	ICGC	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.25
p.P210L	DO48654	SKCM	ICGC	PPPY	ITCH	197:200	Mutation rewiring degron network	0.0556
p.A220T	DO47753	STAD	ICGC	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.7139
p.Q194K	SIDM01292	Esophageal Carcinoma	GDSC	PPPY	ITCH	197:200	Mutation rewiring degron network	0.25
p.M242T	SIDM01099	Neuroblastoma	GDSC	PPPY	ITCH	249:252	Mutation rewiring degron network	0.1389
p.M242T	SK-N-FI	autonomic ganglia	COSMIC	PPPY	ITCH	249:252	Mutation rewiring degron network	0.1389
p.M197T	ACH-000341	Neuroblastoma	CCLE	PPPY	ITCH	197:200	Mutation altering degron motif	0.7423
p.M197T	SK-N-FI	autonomic ganglia	COSMIC	PPPY	ITCH	197:200	Mutation altering degron motif	0.7423
p.M220T	SK-N-FI	autonomic ganglia	COSMIC	VPSTPAAE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.7423

Kaplan plot for WBP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WBP2

UniProt ID: Q969T9

Entrez ID: 23558

Protein name: WW domain-binding protein 2 (WBP-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WBP2 in