DegronMD

Uniprot ID: Q969T9

Source protein: WW domain-binding protein 2

Source gene: WBP2

Class: DEG_SCF_FBW7_2

Location: 213:220

E3 ligase: FBXW7

DEGRON score: 0.8992

ASA_SCORE: 76.6375

COIL: 0.6985

CONS_SCORE: 0.3867

DSS_SCORE: 0.6263

HELIX: 0.2894

FCONS_SCORE: 0.7832

RIG_SCORE: 0.6385

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A221T	TCGA-78-8640	LUAD	TCGA	VPSTPAAE	DEG_SCF_FBW7_2	0.3056
p.A224T	TCGA-CD-8529	STAD	TCGA	VPSTPAAE	DEG_SCF_FBW7_2	0.2222
p.A224T	DO49095	COAD	ICGC	VPSTPAAE	DEG_SCF_FBW7_2	0.2222
p.A224T	SIDM01608	Endometrial Carcinoma	GDSC	VPSTPAAE	DEG_SCF_FBW7_2	0.2222
p.P217S	TCGA-GN-A266	SKCM	TCGA	VPSTPAAE	DEG_SCF_FBW7_2	0.6752
p.A228T	TCGA-NH-A5IV	COAD	TCGA	VPSTPAAE	DEG_SCF_FBW7_2	0.1111
p.P214L	TCGA-QB-A6FS	SKCM	TCGA	VPSTPAAE	DEG_SCF_FBW7_2	0.6471
p.A217D	DO228974	LICA	ICGC	VPSTPAAE	DEG_SCF_FBW7_2	0.7793
p.A217T	DO45340	LUAD	ICGC	VPSTPAAE	DEG_SCF_FBW7_2	0.7139
p.P210L	DO48654	SKCM	ICGC	VPSTPAAE	DEG_SCF_FBW7_2	0.25
p.A220T	DO47753	STAD	ICGC	VPSTPAAE	DEG_SCF_FBW7_2	0.7139
p.M220T	SK-N-FI	autonomic_ganglia	COSMIC	VPSTPAAE	DEG_SCF_FBW7_2	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969T9	WW domain-binding protein 2	DEG_SCF_FBW7_2	213:220	VPSTPAAE	FBXW7	0.8992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons