DegronMD - Q9NX94(WBP1L)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A113V	TCGA-A5-A0G2	UCEC	TCGA	LPPYEE	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.25
p.A113V	TCGA-A5-A0G2	UCEC	TCGA	PPPY	ITCH	119:122	Mutation rewiring degron network	0.1667
p.L132Q	DO227549	COCA	ICGC	PPPY	ITCH	119:122	Mutation rewiring degron network	0.0556
p.P121Q	DO37444	SKCM	ICGC	PPPY	ITCH	119:122	Mutation altering degron motif	0.5924
p.Y124S	SIDM00845	Burkitt's Lymphoma	GDSC	PPPY	ITCH	119:122	Mutation rewiring degron network	0.2778
p.Y124S	SIDM00461	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	119:122	Mutation rewiring degron network	0.2778
p.Y124S	SIDM01519	Head and Neck Carcinoma	GDSC	PPPY	ITCH	119:122	Mutation rewiring degron network	0.2778
p.R96Q	SIDM00966	Ovarian Carcinoma	GDSC	LPPYEE	LIG_APCC_ABBA_1	105:110	Mutation blocking phosphorylation signal	0.5278
p.R96Q	OVCA433	ovary	COSMIC	LPPYEE	LIG_APCC_ABBA_1	105:110	Mutation blocking phosphorylation signal	0.5278
p.R106Q	SIDM01118	Small Cell Lung Carcinoma	GDSC	LPPYEE	LIG_APCC_ABBA_1	105:110	Mutation altering degron motif	0.7329
p.Q131L	ACH-000967	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	119:122	Mutation rewiring degron network	0.0833
p.Y103S	ACH-000992	Head and Neck Cancer	CCLE	LPPYEE	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons