DegronMD - Q8WXX7(AUTS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1012F	TCGA-06-5416	GBM	TCGA	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation altering degron motif	0.7982
p.S1012F	DO10880	GBM	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation altering degron motif	0.7982
p.R938W	TCGA-A5-A0G2	UCEC	TCGA	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation rewiring degron network	0.1667
p.R938W	DO41235	UCEC	ICGC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation rewiring degron network	0.1667
p.A512T	TCGA-AD-6964	COAD	TCGA	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2222
p.A512T	DO8360	COAD	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2222
p.P1006L	TCGA-AD-6964	COAD	TCGA	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.2778
p.P1006L	DO8360	COAD	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.2778
p.P940S	TCGA-AX-A2HD	UCEC	TCGA	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation rewiring degron network	0.2222
p.P940S	DO42608	UCEC	ICGC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation rewiring degron network	0.2222
p.A962V	TCGA-BF-A5ES	SKCM	TCGA	PNSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.2222
p.A962V	DO219456	SKCM	ICGC	PNSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.2222
p.A1002V	TCGA-BF-A5ES	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.1667
p.A1002V	DO219456	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.1667
p.E523K	TCGA-CG-4304	STAD	TCGA	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2222
p.E523K	TCGA-DK-AA6M	BLCA	TCGA	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2222
p.E523K	DO219003	BLCA	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2222
p.E523K	DO38615	STAD	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2222
p.P1016Q	TCGA-CV-7102	HNSC	TCGA	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.2222
p.P1016Q	DO14194	HNSC	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.2222
p.H525Y	TCGA-EE-A29D	SKCM	TCGA	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1667
p.H525Y	TCGA-GN-A266	SKCM	TCGA	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1667
p.H525Y	DO37432	SKCM	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1667
p.H525Y	DO38123	SKCM	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1667
p.S1021L	TCGA-EE-A2GB	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.0833
p.S1021L	TCGA-UF-A71D	HNSC	TCGA	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.0833
p.S1021L	DO52109	HNSC	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.0833
p.S1021L	DO222683	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.0833
p.S1021L	DO37417	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.0833
p.P517S	TCGA-EK-A3GK	CESC	TCGA	PPPY	ITCH	516:519	Mutation altering degron motif	0.6752
p.P517S	DO49964	CESC	ICGC	PPPY	ITCH	516:519	Mutation altering degron motif	0.6752
p.P516L	TCGA-EO-A22U	UCEC	TCGA	PPPY	ITCH	516:519	Mutation altering degron motif	0.7582
p.P516L	DO43755	UCEC	ICGC	PPPY	ITCH	516:519	Mutation altering degron motif	0.7582
p.T522A	TCGA-FI-A2D5	UCEC	TCGA	PPPY	ITCH	516:519	Mutation rewiring degron network	0.25
p.T522A	DO41331	UCEC	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.25
p.G1017R	TCGA-FR-A726	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.1944
p.G1017R	DO48665	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.1944
p.P1005L	TCGA-QB-A6FS	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.25
p.P1005L	DO48654	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.25
p.R510H	TCGA-RD-A7BW	STAD	TCGA	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1667
p.R510H	DO48612	STAD	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1667
p.R510H	SIDM00596	Endometrial Carcinoma	GDSC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1667
p.R510H	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1667
p.R510H	HEC-1	endometrium	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1667
p.P947L	TCGA-ZS-A9CE	LIHC	TCGA	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation altering degron motif	0.7582
p.P947L	DO49720	LIHC	ICGC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation altering degron motif	0.7582
p.R521Q	DO225159	BRCA	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2778
p.R521Q	DO227790	BRCA	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2778
p.R521Q	DO230342	COCA	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2778
p.R521W	DO230337	COCA	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2778
p.S1011L	DO234400	ESAD	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation altering degron motif	0.7667
p.P1007H	DO233259	GACA	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.3056
p.P942S	DO233673	GACA	ICGC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation rewiring degron network	0.2778
p.P942S	SIDM00059	Ovarian Carcinoma	GDSC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation rewiring degron network	0.2778
p.G511R	DO233884	GACA	ICGC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1944
p.G967V	DO23322	LINC	ICGC	PNSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.0833
p.E1004K	DO228824	MALY	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.2222
p.P1018L	DO220877	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.1667
p.R945W	SIDM02015	Colorectal Carcinoma	GDSC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation altering degron motif	0.7523
p.N1009S	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation altering degron motif	0.5958
p.N1009S	ACH-000534	Lymphoma	CCLE	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation altering degron motif	0.5958
p.N1009S	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation altering degron motif	0.5958
p.V944L	SIDM00120	Prostate Carcinoma	GDSC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation altering degron motif	0.5654
p.V944L	ACH-000979	Prostate Cancer	CCLE	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation altering degron motif	0.5654
p.V944L	DU-145	prostate	COSMIC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation altering degron motif	0.5654
p.V1014M	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.2778
p.V1014M	ACH-000015	Lung Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.2778
p.V1014M	ACH-001738	Leukemia	CCLE	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.2778
p.V1014M	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.2778
p.G511V	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1944
p.G511V	ACH-000852	Lung Cancer	CCLE	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1944
p.G511V	NCI-H1435	lung	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1944
p.G515V	SIDM01042	Breast Carcinoma	GDSC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.3056
p.G515V	ACH-001065	Breast Cancer	CCLE	PPPY	ITCH	516:519	Mutation rewiring degron network	0.3056
p.G515V	EVSA-T	breast	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.3056
p.R945Q	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation altering degron motif	0.6218
p.R945Q	ACH-000390	Lung Cancer	CCLE	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation altering degron motif	0.6218
p.V943L	DU-145	prostate	COSMIC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation blocking phosphorylation signal	0.75
p.G514V	EVSA-T	breast	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2778
p.A947T	SNU-1040	large intestine	COSMIC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation altering degron motif	0.7139
p.G514R	MFE-319	endometrium	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.2778
p.V1013M	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.3056
p.M526I	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1389
p.A953T	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	VRTPVVE	DEG_SCF_FBW7_2	944:950	Mutation rewiring degron network	0.25
p.A953T	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PNSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.3056
p.T522I	AN3-CA	endometrium	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.25
p.G528S	OVISE	ovary	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.0833
p.R509H	HEC-1	endometrium	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1389
p.S961C	AU565	breast	COSMIC	PNSTS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.25
p.N1008S	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation altering degron motif	0.7069
p.M526V	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1389
p.P1009S	HT-29	large intestine	COSMIC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation altering degron motif	0.6752
p.G510V	NCI-H1435	lung	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1667
p.L1016P	A2780	ovary	COSMIC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.2222
p.P520L	A498	kidney	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.3056
p.D1017E	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	1008:1012	Mutation rewiring degron network	0.1944
p.G508S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	516:519	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AUTS2

UniProt ID: Q8WXX7

Entrez ID: 26053

Protein name: Autism susceptibility gene 2 protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AUTS2 in