DegronMD

Uniprot ID: Q8WXX7

Source protein: Autism susceptibility gene 2 protein

Source gene: AUTS2

Class: DEG_SCF_FBW7_2

Location: 944:950

E3 ligase: FBXW7

DEGRON score: 0.9254

ASA_SCORE: 98.7571

COIL: 0.8851

CONS_SCORE: 0.3804

DSS_SCORE: 0.6214

HELIX: 0.0909

FCONS_SCORE: 0.8495

RIG_SCORE: 0.7114

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R938W	TCGA-A5-A0G2	UCEC	TCGA	VRTPVVE	DEG_SCF_FBW7_2	0.1667
p.R938W	DO41235	UCEC	ICGC	VRTPVVE	DEG_SCF_FBW7_2	0.1667
p.P940S	TCGA-AX-A2HD	UCEC	TCGA	VRTPVVE	DEG_SCF_FBW7_2	0.2222
p.P940S	DO42608	UCEC	ICGC	VRTPVVE	DEG_SCF_FBW7_2	0.2222
p.P947L	TCGA-ZS-A9CE	LIHC	TCGA	VRTPVVE	DEG_SCF_FBW7_2	0.7582
p.P947L	DO49720	LIHC	ICGC	VRTPVVE	DEG_SCF_FBW7_2	0.7582
p.P942S	DO233673	GACA	ICGC	VRTPVVE	DEG_SCF_FBW7_2	0.2778
p.P942S	SIDM00059	Ovarian Carcinoma	GDSC	VRTPVVE	DEG_SCF_FBW7_2	0.2778
p.R945W	SIDM02015	Colorectal Carcinoma	GDSC	VRTPVVE	DEG_SCF_FBW7_2	0.7523
p.V944L	SIDM00120	Prostate Carcinoma	GDSC	VRTPVVE	DEG_SCF_FBW7_2	0.5654
p.V944L	ACH-000979	Prostate Cancer	CCLE	VRTPVVE	DEG_SCF_FBW7_2	0.5654
p.V944L	DU-145	prostate	COSMIC	VRTPVVE	DEG_SCF_FBW7_2	0.5654
p.R945Q	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	VRTPVVE	DEG_SCF_FBW7_2	0.6218
p.R945Q	ACH-000390	Lung Cancer	CCLE	VRTPVVE	DEG_SCF_FBW7_2	0.6218
p.V943L	DU-145	prostate	COSMIC	VRTPVVE	DEG_SCF_FBW7_2	0.75
p.A947T	SNU-1040	large_intestine	COSMIC	VRTPVVE	DEG_SCF_FBW7_2	0.7139
p.A953T	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	VRTPVVE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SCF_FBW7_2	944:950	VRTPVVE	FBXW7	0.9254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons