DegronMD

Uniprot ID: Q8WXX7

Source protein: Autism susceptibility gene 2 protein

Source gene: AUTS2

Class: DEG_SPOP_SBC_1

Location: 954:958

E3 ligase: SPOP

DEGRON score: 0.9978

ASA_SCORE: 78.56

COIL: 0.9084

CONS_SCORE: 0.4116

DSS_SCORE: 0.6652

HELIX: 0.0816

FCONS_SCORE: 1.0607

RIG_SCORE: 0.5602

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A962V	TCGA-BF-A5ES	SKCM	TCGA	PNSTS	DEG_SPOP_SBC_1	0.2222
p.A962V	DO219456	SKCM	ICGC	PNSTS	DEG_SPOP_SBC_1	0.2222
p.G967V	DO23322	LINC	ICGC	PNSTS	DEG_SPOP_SBC_1	0.0833
p.A953T	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PNSTS	DEG_SPOP_SBC_1	0.3056
p.S961C	AU565	breast	COSMIC	PNSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14258	E3 ubiquitin/ISG15 ligase TRIM25	DEG_SPOP_SBC_1	431:435	PNSTS	SPOP	0.9986	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	954:958	PNSTS	SPOP	0.9978	More...
Q9UI40	Sodium/potassium/calcium exchanger 2	DEG_SPOP_SBC_1	415:419	PNSTS	SPOP	0.9879	More...
Q86XR5	Proline-rich membrane anchor 1	DEG_SPOP_SBC_1	78:82	PNSTS	SPOP	0.5226	More...
Q7Z422	SUZ domain-containing protein 1	DEG_SPOP_SBC_1	75:79	PNSTS	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons