DegronMD - Q9UI40(SLC24A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A405S	TCGA-18-3415	LUSC	TCGA	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.0556
p.A405S	DO26427	LUSC	ICGC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.0556
p.D421N	TCGA-3N-A9WD	SKCM	TCGA	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.2778
p.D421N	TCGA-GC-A3BM	BLCA	TCGA	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.2778
p.D421N	DO446	BLCA	ICGC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.2778
p.D421N	DO51235	SKCM	ICGC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.2778
p.S427Y	TCGA-69-7765	LUAD	TCGA	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1111
p.S427Y	DO23580	LUAD	ICGC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1111
p.R85I	TCGA-AA-3977	COAD	TCGA	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.1667
p.R85I	DO8730	COAD	ICGC	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.1667
p.K93N	TCGA-B5-A1MR	UCEC	TCGA	NDKILDYTPQP	CBL_PTK	91:101	Mutation altering degron motif	0.5806
p.K93N	TCGA-DK-A3WW	BLCA	TCGA	NDKILDYTPQP	CBL_PTK	91:101	Mutation altering degron motif	0.5806
p.K93N	DO481	BLCA	ICGC	NDKILDYTPQP	CBL_PTK	91:101	Mutation altering degron motif	0.5806
p.K93N	DO41758	UCEC	ICGC	NDKILDYTPQP	CBL_PTK	91:101	Mutation altering degron motif	0.5806
p.S104Y	TCGA-C8-A134	BRCA	TCGA	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.25
p.S104Y	DO1316	BRCA	ICGC	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.25
p.G81S	TCGA-ER-A19G	SKCM	TCGA	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.0556
p.G81S	DO47284	SKCM	ICGC	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.0556
p.N416S	TCGA-F5-6814	READ	TCGA	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation altering degron motif	0.5958
p.N416S	DO36556	READ	ICGC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation altering degron motif	0.5958
p.E110Q	TCGA-KQ-A41S	BLCA	TCGA	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.0833
p.E110Q	DO223593	BLCA	ICGC	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.0833
p.P99Q	DO230309	COCA	ICGC	NDKILDYTPQP	CBL_PTK	91:101	Mutation altering degron motif	0.5924
p.E110G	DO230342	COCA	ICGC	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.0833
p.L88V	DO218088	GACA	ICGC	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.25
p.I94F	DO233090	GACA	ICGC	NDKILDYTPQP	CBL_PTK	91:101	Mutation altering degron motif	0.6304
p.S419R	DO229028	LICA	ICGC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation altering degron motif	0.7427
p.A406T	DO233294	NACA	ICGC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.0833
p.Q84R	SIDM01307	Colorectal Carcinoma	GDSC	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.1389
p.S104C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.25
p.S104C	ACH-000981	Leukemia	CCLE	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.25
p.S104C	DND-41	haematopoietic and lymphoid tissue	COSMIC	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.25
p.T425I	SIDM00969	Ovarian Carcinoma	GDSC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1667
p.T425I	DOV13	ovary	COSMIC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1667
p.D96N	SIDM00193	Colorectal Carcinoma	GDSC	NDKILDYTPQP	CBL_PTK	91:101	Mutation altering degron motif	0.5821
p.D96N	ACH-000991	Colon/Colorectal Cancer	CCLE	NDKILDYTPQP	CBL_PTK	91:101	Mutation altering degron motif	0.5821
p.D96N	SNU-81	large intestine	COSMIC	NDKILDYTPQP	CBL_PTK	91:101	Mutation altering degron motif	0.5821
p.I412T	SIDM01083	Oral Cavity Carcinoma	GDSC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.25
p.I412T	ACH-000254	Head and Neck Cancer	CCLE	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.25
p.I412T	SCC-15	upper aerodigestive tract	COSMIC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.25
p.L88S	ACH-000829	Myeloma	CCLE	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.25
p.E108K	ACH-001456	Colon/Colorectal Cancer	CCLE	NDKILDYTPQP	CBL_PTK	91:101	Mutation rewiring degron network	0.1389
p.H424Q	KYSE-450	oesophagus	COSMIC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1944
p.L422F	M14	skin	COSMIC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.25
p.Q418K	NCI-H345	lung	COSMIC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation altering degron motif	0.6944
p.T408I	DOV13	ovary	COSMIC	PNSTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1389

Kaplan plot for SLC24A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC24A2

UniProt ID: Q9UI40

Entrez ID: 25769

Protein name: Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC24A2 in