DegronMD

Uniprot ID: Q9UI40

Source protein: Sodium/potassium/calcium exchanger 2

Source gene: SLC24A2

Class: CBL_PTK

Location: 91:101

E3 ligase: CBL

DEGRON score: 0.5067

ASA_SCORE: 88.6364

COIL: 0.7926

CONS_SCORE: 0.3508

DSS_SCORE: 0.5877

HELIX: 0.1057

FCONS_SCORE: 0.9369

RIG_SCORE: 0.7635

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R85I	TCGA-AA-3977	COAD	TCGA	NDKILDYTPQP	CBL_PTK	0.1667
p.R85I	DO8730	COAD	ICGC	NDKILDYTPQP	CBL_PTK	0.1667
p.K93N	TCGA-B5-A1MR	UCEC	TCGA	NDKILDYTPQP	CBL_PTK	0.5806
p.K93N	TCGA-DK-A3WW	BLCA	TCGA	NDKILDYTPQP	CBL_PTK	0.5806
p.K93N	DO481	BLCA	ICGC	NDKILDYTPQP	CBL_PTK	0.5806
p.K93N	DO41758	UCEC	ICGC	NDKILDYTPQP	CBL_PTK	0.5806
p.S104Y	TCGA-C8-A134	BRCA	TCGA	NDKILDYTPQP	CBL_PTK	0.25
p.S104Y	DO1316	BRCA	ICGC	NDKILDYTPQP	CBL_PTK	0.25
p.G81S	TCGA-ER-A19G	SKCM	TCGA	NDKILDYTPQP	CBL_PTK	0.0556
p.G81S	DO47284	SKCM	ICGC	NDKILDYTPQP	CBL_PTK	0.0556
p.E110Q	TCGA-KQ-A41S	BLCA	TCGA	NDKILDYTPQP	CBL_PTK	0.0833
p.E110Q	DO223593	BLCA	ICGC	NDKILDYTPQP	CBL_PTK	0.0833
p.P99Q	DO230309	COCA	ICGC	NDKILDYTPQP	CBL_PTK	0.5924
p.E110G	DO230342	COCA	ICGC	NDKILDYTPQP	CBL_PTK	0.0833
p.L88V	DO218088	GACA	ICGC	NDKILDYTPQP	CBL_PTK	0.25
p.I94F	DO233090	GACA	ICGC	NDKILDYTPQP	CBL_PTK	0.6304
p.Q84R	SIDM01307	Colorectal Carcinoma	GDSC	NDKILDYTPQP	CBL_PTK	0.1389
p.S104C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	NDKILDYTPQP	CBL_PTK	0.25
p.S104C	ACH-000981	Leukemia	CCLE	NDKILDYTPQP	CBL_PTK	0.25
p.S104C	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	NDKILDYTPQP	CBL_PTK	0.25
p.D96N	SIDM00193	Colorectal Carcinoma	GDSC	NDKILDYTPQP	CBL_PTK	0.5821
p.D96N	ACH-000991	Colon/Colorectal Cancer	CCLE	NDKILDYTPQP	CBL_PTK	0.5821
p.D96N	SNU-81	large_intestine	COSMIC	NDKILDYTPQP	CBL_PTK	0.5821
p.L88S	ACH-000829	Myeloma	CCLE	NDKILDYTPQP	CBL_PTK	0.25
p.E108K	ACH-001456	Colon/Colorectal Cancer	CCLE	NDKILDYTPQP	CBL_PTK	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UI40	Sodium/potassium/calcium exchanger 2	CBL_PTK	91:101	NDKILDYTPQP	CBL	0.5067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons