DegronMD

Uniprot ID: Q9UI40

Source protein: Sodium/potassium/calcium exchanger 2

Source gene: SLC24A2

Class: DEG_SPOP_SBC_1

Location: 415:419

E3 ligase: SPOP

DEGRON score: 0.9879

ASA_SCORE: 74.4

COIL: 0.8414

CONS_SCORE: 0.3873

DSS_SCORE: 0.6632

HELIX: 0.0664

FCONS_SCORE: 1.0311

RIG_SCORE: 0.6277

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A405S	TCGA-18-3415	LUSC	TCGA	PNSTS	DEG_SPOP_SBC_1	0.0556
p.A405S	DO26427	LUSC	ICGC	PNSTS	DEG_SPOP_SBC_1	0.0556
p.D421N	TCGA-3N-A9WD	SKCM	TCGA	PNSTS	DEG_SPOP_SBC_1	0.2778
p.D421N	TCGA-GC-A3BM	BLCA	TCGA	PNSTS	DEG_SPOP_SBC_1	0.2778
p.D421N	DO446	BLCA	ICGC	PNSTS	DEG_SPOP_SBC_1	0.2778
p.D421N	DO51235	SKCM	ICGC	PNSTS	DEG_SPOP_SBC_1	0.2778
p.S427Y	TCGA-69-7765	LUAD	TCGA	PNSTS	DEG_SPOP_SBC_1	0.1111
p.S427Y	DO23580	LUAD	ICGC	PNSTS	DEG_SPOP_SBC_1	0.1111
p.N416S	TCGA-F5-6814	READ	TCGA	PNSTS	DEG_SPOP_SBC_1	0.5958
p.N416S	DO36556	READ	ICGC	PNSTS	DEG_SPOP_SBC_1	0.5958
p.S419R	DO229028	LICA	ICGC	PNSTS	DEG_SPOP_SBC_1	0.7427
p.A406T	DO233294	NACA	ICGC	PNSTS	DEG_SPOP_SBC_1	0.0833
p.T425I	SIDM00969	Ovarian Carcinoma	GDSC	PNSTS	DEG_SPOP_SBC_1	0.1667
p.T425I	DOV13	ovary	COSMIC	PNSTS	DEG_SPOP_SBC_1	0.1667
p.I412T	SIDM01083	Oral Cavity Carcinoma	GDSC	PNSTS	DEG_SPOP_SBC_1	0.25
p.I412T	ACH-000254	Head and Neck Cancer	CCLE	PNSTS	DEG_SPOP_SBC_1	0.25
p.I412T	SCC-15	upper_aerodigestive_tract	COSMIC	PNSTS	DEG_SPOP_SBC_1	0.25
p.H424Q	KYSE-450	oesophagus	COSMIC	PNSTS	DEG_SPOP_SBC_1	0.1944
p.L422F	M14	skin	COSMIC	PNSTS	DEG_SPOP_SBC_1	0.25
p.Q418K	NCI-H345	lung	COSMIC	PNSTS	DEG_SPOP_SBC_1	0.6944
p.T408I	DOV13	ovary	COSMIC	PNSTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14258	E3 ubiquitin/ISG15 ligase TRIM25	DEG_SPOP_SBC_1	431:435	PNSTS	SPOP	0.9986	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	954:958	PNSTS	SPOP	0.9978	More...
Q9UI40	Sodium/potassium/calcium exchanger 2	DEG_SPOP_SBC_1	415:419	PNSTS	SPOP	0.9879	More...
Q86XR5	Proline-rich membrane anchor 1	DEG_SPOP_SBC_1	78:82	PNSTS	SPOP	0.5226	More...
Q7Z422	SUZ domain-containing protein 1	DEG_SPOP_SBC_1	75:79	PNSTS	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons