DegronMD - Q7Z422(SZRD1)

SZRD1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L88I	TCGA-53-7626	LUAD	TCGA	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.0833
p.T67I	TCGA-A8-A090	BRCA	TCGA	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation blocking phosphorylation signal	0.5556
p.R65G	TCGA-CJ-5676	KIRC	TCGA	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.0556
p.R79W	DO5521	BRCA	ICGC	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation altering degron motif	0.8634
p.E89K	DO51632	CESC	ICGC	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.0556
p.R81Q	DO230321	COCA	ICGC	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2778
p.R81Q	DO41235	UCEC	ICGC	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2778
p.E74K	DO234229	ESAD	ICGC	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation blocking phosphorylation signal	0.75
p.E72K	DO218923	LUAD	ICGC	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.25
p.L68I	DO23774	LUAD	ICGC	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation blocking phosphorylation signal	0.5833
p.P88L	DO37429	SKCM	ICGC	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.0833
p.G84A	DO38296	STAD	ICGC	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.1944
p.T82A	SIDM00845	Burkitt's Lymphoma	GDSC	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation blocking phosphorylation signal	0.6944
p.N76S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PNSTS	DEG_SPOP_SBC_1	75:79	Mutation altering degron motif	0.5958

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*NOTE: the Kaplan plots were collected from OncoLnc