DegronMD

Uniprot ID: Q7Z422

Source protein: SUZ domain-containing protein 1

Source gene: SZRD1

Class: DEG_SPOP_SBC_1

Location: 75:79

E3 ligase: SPOP

DEGRON score: 0.9778

ASA_SCORE: 99.7

COIL: 0.945

CONS_SCORE: 0.5927

DSS_SCORE: 0.6223

HELIX: 0.049

FCONS_SCORE: 0.9221

RIG_SCORE: 0.5709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L88I	TCGA-53-7626	LUAD	TCGA	PNSTS	DEG_SPOP_SBC_1	0.0833
p.T67I	TCGA-A8-A090	BRCA	TCGA	PNSTS	DEG_SPOP_SBC_1	0.5556
p.R65G	TCGA-CJ-5676	KIRC	TCGA	PNSTS	DEG_SPOP_SBC_1	0.0556
p.R79W	DO5521	BRCA	ICGC	PNSTS	DEG_SPOP_SBC_1	0.8634
p.E89K	DO51632	CESC	ICGC	PNSTS	DEG_SPOP_SBC_1	0.0556
p.R81Q	DO230321	COCA	ICGC	PNSTS	DEG_SPOP_SBC_1	0.2778
p.R81Q	DO41235	UCEC	ICGC	PNSTS	DEG_SPOP_SBC_1	0.2778
p.E74K	DO234229	ESAD	ICGC	PNSTS	DEG_SPOP_SBC_1	0.75
p.E72K	DO218923	LUAD	ICGC	PNSTS	DEG_SPOP_SBC_1	0.25
p.L68I	DO23774	LUAD	ICGC	PNSTS	DEG_SPOP_SBC_1	0.5833
p.P88L	DO37429	SKCM	ICGC	PNSTS	DEG_SPOP_SBC_1	0.0833
p.G84A	DO38296	STAD	ICGC	PNSTS	DEG_SPOP_SBC_1	0.1944
p.T82A	SIDM00845	Burkitt's Lymphoma	GDSC	PNSTS	DEG_SPOP_SBC_1	0.6944
p.N76S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PNSTS	DEG_SPOP_SBC_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14258	E3 ubiquitin/ISG15 ligase TRIM25	DEG_SPOP_SBC_1	431:435	PNSTS	SPOP	0.9986	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	954:958	PNSTS	SPOP	0.9978	More...
Q9UI40	Sodium/potassium/calcium exchanger 2	DEG_SPOP_SBC_1	415:419	PNSTS	SPOP	0.9879	More...
Q86XR5	Proline-rich membrane anchor 1	DEG_SPOP_SBC_1	78:82	PNSTS	SPOP	0.5226	More...
Q7Z422	SUZ domain-containing protein 1	DEG_SPOP_SBC_1	75:79	PNSTS	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons