DegronMD

Uniprot ID: Q86XR5

Source protein: Proline-rich membrane anchor 1

Source gene: PRIMA1

Class: DEG_SPOP_SBC_1

Location: 78:82

E3 ligase: SPOP

DEGRON score: 0.5226

ASA_SCORE: 86.44

COIL: 0.9106

CONS_SCORE: 0.6186

DSS_SCORE: 0.444

HELIX: 0.0246

FCONS_SCORE: 0.948

RIG_SCORE: 0.602

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G92W	TCGA-05-4396	LUAD	TCGA	PNSTS	DEG_SPOP_SBC_1	0.0556
p.G92W	TCGA-GN-A26C	SKCM	TCGA	PNSTS	DEG_SPOP_SBC_1	0.0556
p.G92W	TCGA-HE-7129	KIRP	TCGA	PNSTS	DEG_SPOP_SBC_1	0.0556
p.G92W	DO20786	KIRP	ICGC	PNSTS	DEG_SPOP_SBC_1	0.0556
p.G92W	DO23838	LUAD	ICGC	PNSTS	DEG_SPOP_SBC_1	0.0556
p.G92W	DO37782	SKCM	ICGC	PNSTS	DEG_SPOP_SBC_1	0.0556
p.S74C	TCGA-CV-7414	HNSC	TCGA	PNSTS	DEG_SPOP_SBC_1	0.2222
p.S74C	DO15631	HNSC	ICGC	PNSTS	DEG_SPOP_SBC_1	0.2222
p.S82F	TCGA-EE-A3AC	SKCM	TCGA	PNSTS	DEG_SPOP_SBC_1	0.7982
p.S82F	DO37631	SKCM	ICGC	PNSTS	DEG_SPOP_SBC_1	0.7982
p.S88I	TCGA-EO-A22R	UCEC	TCGA	PNSTS	DEG_SPOP_SBC_1	0.1667
p.S88I	DO42713	UCEC	ICGC	PNSTS	DEG_SPOP_SBC_1	0.1667
p.P76T	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	PNSTS	DEG_SPOP_SBC_1	0.2778
p.P76T	ACH-000841	Lung Cancer	CCLE	PNSTS	DEG_SPOP_SBC_1	0.2778
p.P76T	NCI-H2087	lung	COSMIC	PNSTS	DEG_SPOP_SBC_1	0.2778
p.R71T	ACH-000891	Lung Cancer	CCLE	PNSTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14258	E3 ubiquitin/ISG15 ligase TRIM25	DEG_SPOP_SBC_1	431:435	PNSTS	SPOP	0.9986	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	954:958	PNSTS	SPOP	0.9978	More...
Q9UI40	Sodium/potassium/calcium exchanger 2	DEG_SPOP_SBC_1	415:419	PNSTS	SPOP	0.9879	More...
Q86XR5	Proline-rich membrane anchor 1	DEG_SPOP_SBC_1	78:82	PNSTS	SPOP	0.5226	More...
Q7Z422	SUZ domain-containing protein 1	DEG_SPOP_SBC_1	75:79	PNSTS	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons