DegronMD - Q86XR5(PRIMA1)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G92W	TCGA-05-4396	LUAD	TCGA	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.0556
p.G92W	TCGA-GN-A26C	SKCM	TCGA	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.0556
p.G92W	TCGA-HE-7129	KIRP	TCGA	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.0556
p.G92W	DO20786	KIRP	ICGC	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.0556
p.G92W	DO23838	LUAD	ICGC	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.0556
p.G92W	DO37782	SKCM	ICGC	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.0556
p.S74C	TCGA-CV-7414	HNSC	TCGA	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2222
p.S74C	DO15631	HNSC	ICGC	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2222
p.S82F	TCGA-EE-A3AC	SKCM	TCGA	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.7982
p.S82F	DO37631	SKCM	ICGC	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.7982
p.S88I	TCGA-EO-A22R	UCEC	TCGA	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1667
p.S88I	DO42713	UCEC	ICGC	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1667
p.P76T	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2778
p.P76T	ACH-000841	Lung Cancer	CCLE	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2778
p.P76T	NCI-H2087	lung	COSMIC	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2778
p.R71T	ACH-000891	Lung Cancer	CCLE	PNSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons