DegronMD

Uniprot ID: Q14258

Source protein: E3 ubiquitin/ISG15 ligase TRIM25

Source gene: TRIM25

Class: DEG_SPOP_SBC_1

Location: 431:435

E3 ligase: SPOP

DEGRON score: 0.9986

ASA_SCORE: 77.42

COIL: 0.7248

CONS_SCORE: 0.3992

DSS_SCORE: 0.3538

HELIX: 0.1584

FCONS_SCORE: 1.0667

RIG_SCORE: 0.6558

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N432S	TCGA-A5-A0G2	UCEC	TCGA	PNSTS	DEG_SPOP_SBC_1	0.5958
p.N432S	DO41235	UCEC	ICGC	PNSTS	DEG_SPOP_SBC_1	0.5958
p.L445P	TCGA-EY-A1GU	UCEC	TCGA	PNSTS	DEG_SPOP_SBC_1	0.0556
p.L445P	DO41518	UCEC	ICGC	PNSTS	DEG_SPOP_SBC_1	0.0556
p.A423S	DO50952	LICA	ICGC	PNSTS	DEG_SPOP_SBC_1	0.1111
p.V440G	DO219878	SKCA	ICGC	PNSTS	DEG_SPOP_SBC_1	0.1944
p.F444L	DO229234	THCA	ICGC	PNSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14258	E3 ubiquitin/ISG15 ligase TRIM25	DEG_SPOP_SBC_1	431:435	PNSTS	SPOP	0.9986	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	954:958	PNSTS	SPOP	0.9978	More...
Q9UI40	Sodium/potassium/calcium exchanger 2	DEG_SPOP_SBC_1	415:419	PNSTS	SPOP	0.9879	More...
Q86XR5	Proline-rich membrane anchor 1	DEG_SPOP_SBC_1	78:82	PNSTS	SPOP	0.5226	More...
Q7Z422	SUZ domain-containing protein 1	DEG_SPOP_SBC_1	75:79	PNSTS	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons