DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPPY
Uniprot ID:
Q6UXU6
Source protein:
Transmembrane protein 92
Source gene:
TMEM92
Class:
ITCH
Location:
117:120
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.54
ASA_SCORE:
46.25
COIL:
0.777
CONS_SCORE:
0.779
DSS_SCORE:
0.4395
HELIX:
0.1788
FCONS_SCORE:
1.608
RIG_SCORE:
0.6008
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P119L
SIDM00189
Melanoma
GDSC
PPPY
ITCH
0.6471
p.P119L
ACH-002098
Skin Cancer
CCLE
PPPY
ITCH
0.6471
p.P119L
CP67-MEL
skin
COSMIC
PPPY
ITCH
0.6471
p.K126M
TCGA-RC-A7SK
LIHC
TCGA
PPPY
ITCH
0.2778
p.K126M
DO52314
LIHC
ICGC
PPPY
ITCH
0.2778
p.A115V
SIDM01617
Endometrial Carcinoma
GDSC
PPPY
ITCH
0.2778
p.A115V
ACH-000994
Endometrial/Uterine Cancer
CCLE
PPPY
ITCH
0.2778
p.V111L
TCGA-DF-A2KU
UCEC
TCGA
PPPY
ITCH
0.1667
p.V111L
DO223286
UCEC
ICGC
PPPY
ITCH
0.1667
p.R108K
TCGA-W3-AA1R
SKCM
TCGA
PPPY
ITCH
0.0833
p.R108K
DO51275
SKCM
ICGC
PPPY
ITCH
0.0833
p.R108S
DO228986
LICA
ICGC
PPPY
ITCH
0.0833
p.G130S
TCGA-13-1507
OV
TCGA
PPPY
ITCH
0.0556
p.G130S
DO27991
OV
ICGC
PPPY
ITCH
0.0556
p.E107D
TCGA-E7-A541
BLCA
TCGA
PPPY
ITCH
0.0556
p.E107D
DO44037
BLCA
ICGC
PPPY
ITCH
0.0556
Showing 1 to 16 of 16 entries
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Drug responses associated with TMEM92 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPPY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96DV4
39S ribosomal protein L38, mitochondrial
ITCH
347:350
PPPY
ITCH,NEDD4
0.6466
More...
O15072
A disintegrin and metalloproteinase with thrombospondin motifs 3
ITCH
1058:1061
PPPY
ITCH,NEDD4
0.9797
More...
Q13625
Apoptosis-stimulating of p53 protein 2
ITCH
871:874
PPPY
ITCH,NEDD4
0.9885
More...
P54259
Atrophin-1
ITCH
445:448
PPPY
ITCH,NEDD4
0.973
More...
P54259
Atrophin-1
ITCH
636:639
PPPY
ITCH,NEDD4
0.9909
More...
Q8WXX7
Autism susceptibility gene 2 protein
ITCH
516:519
PPPY
ITCH,NEDD4
0.9979
More...
O00512
B-cell CLL/lymphoma 9 protein
ITCH
515:518
PPPY
ITCH,NEDD4
0.9973
More...
Q86UU0
B-cell CLL/lymphoma 9-like protein
ITCH
561:564
PPPY
ITCH,NEDD4
0.9923
More...
O95395
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
ITCH
285:288
PPPY
ITCH,NEDD4
0.5532
More...
O95415
Brain protein I3
ITCH
39:42
PPPY
ITCH,NEDD4
0.9496
More...
Q15018
BRISC complex subunit Abraxas 2
ITCH
305:308
PPPY
ITCH,NEDD4
0.9939
More...
Q9P203
BTB/POZ domain-containing protein 7
ITCH
762:765
PPPY
ITCH,NEDD4
0.9575
More...
Q9Y6W3
Calpain-7
ITCH
624:627
PPPY
ITCH,NEDD4
0.5393
More...
Q8WXE0
Caskin-2
ITCH
751:754
PPPY
ITCH,NEDD4
0.6879
More...
Q9H305
Cell death-inducing p53-target protein 1
ITCH
6:9
PPPY
ITCH,NEDD4
0.9945
More...
Q9H305
Cell death-inducing p53-target protein 1
ITCH
51:54
PPPY
ITCH,NEDD4
0.9943
More...
Q16630
Cleavage and polyadenylation specificity factor subunit 6
ITCH
387:390
PPPY
ITCH,NEDD4
0.9919
More...
Q8WXI2
Connector enhancer of kinase suppressor of ras 2
ITCH
704:707
PPPY
ITCH,NEDD4
0.9478
More...
Q86YQ8
Copine-8
ITCH
550:553
PPPY
ITCH,NEDD4
0.743
More...
Q6UUV7
CREB-regulated transcription coactivator 3
ITCH
445:448
PPPY
ITCH,NEDD4
0.998
More...
Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
113:116
PPPY
ITCH,NEDD4
0.9396
More...
Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
129:132
PPPY
ITCH,NEDD4
0.9428
More...
Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
145:148
PPPY
ITCH,NEDD4
0.9794
More...
Q9H1C7
Cysteine-rich and transmembrane domain-containing protein 1
ITCH
6:9
PPPY
ITCH,NEDD4
0.9391
More...
Q9BTC0
Death-inducer obliterator 1
ITCH
1817:1820
PPPY
ITCH,NEDD4
0.9967
More...
Showing 1 to 25 of 180 entries
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