DegronMD - Q13950(RUNX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T481M	TCGA-19-2621	GBM	TCGA	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1944
p.P320T	TCGA-53-7626	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7031
p.S247I	TCGA-56-7731	LUSC	TCGA	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation blocking phosphorylation signal	0.6944
p.P424Q	TCGA-86-8358	LUAD	TCGA	PPPY	ITCH	423:426	Mutation altering degron motif	0.7035
p.R245L	TCGA-97-A4M7	LUAD	TCGA	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.3056
p.R251C	TCGA-AP-A1DV	UCEC	TCGA	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.1389
p.G428D	TCGA-AP-A1DV	UCEC	TCGA	PPPY	ITCH	423:426	Mutation rewiring degron network	0.2778
p.G428D	TCGA-VQ-A924	STAD	TCGA	PPPY	ITCH	423:426	Mutation rewiring degron network	0.2778
p.P373R	TCGA-AR-A24Q	BRCA	TCGA	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.3056
p.R251H	TCGA-AX-A1C5	UCEC	TCGA	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.1389
p.R251H	TCGA-XK-AAIW	PRAD	TCGA	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.1389
p.R325Q	TCGA-BB-8596	HNSC	TCGA	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.A331V	TCGA-BF-AAP7	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1389
p.A331V	TCGA-DU-6407	LGG	TCGA	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1389
p.T415A	TCGA-CD-A4MG	STAD	TCGA	PPPY	ITCH	423:426	Mutation rewiring degron network	0.1111
p.S477L	TCGA-D1-A17Q	UCEC	TCGA	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.3056
p.S477L	SIDM01588	Endometrial Carcinoma	GDSC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.3056
p.S477L	ACH-000993	Endometrial/Uterine Cancer	CCLE	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.3056
p.M310T	TCGA-DI-A1BU	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.D20N	TCGA-EE-A2MS	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.T476N	TCGA-EY-A1GU	UCEC	TCGA	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7055
p.P29T	TCGA-F7-A50I	HNSC	TCGA	PPSSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7031
p.P320L	TCGA-FS-A1ZK	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7582
p.P466S	TCGA-FS-A1ZK	SKCM	TCGA	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1667
p.S312F	TCGA-FU-A3HZ	CESC	TCGA	PLSST	DEG_SPOP_SBC_1	320:324	Mutation blocking phosphorylation signal	0.5556
p.T476I	TCGA-IB-7651	PAAD	TCGA	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7078
p.T318S	TCGA-L9-A8F4	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2778
p.T311M	TCGA-VQ-A8P2	STAD	TCGA	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0833
p.D372V	TCGA-VR-A8ER	ESCA	TCGA	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7785
p.P425S	TCGA-VS-A9UJ	CESC	TCGA	PPPY	ITCH	423:426	Mutation altering degron motif	0.5641
p.P29S	TCGA-YD-A9TA	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6752
p.R237Q	DO2937	BRCA	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation blocking phosphorylation signal	0.75
p.R237Q	DO222628	MELA	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation blocking phosphorylation signal	0.75
p.R237Q	DO37539	SKCM	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation blocking phosphorylation signal	0.75
p.R254I	DO2401	BRCA	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.0556
p.S380F	DO6308	CESC	ICGC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1111
p.R237W	DO10020	COAD	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation blocking phosphorylation signal	0.75
p.P40S	DO7962	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1389
p.D229N	DO9876	COAD	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.0833
p.P372R	DO52438	COCA	ICGC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7512
p.P421L	DO234230	ESAD	ICGC	PPPY	ITCH	423:426	Mutation rewiring degron network	0.2778
p.P421L	DO232761	PBCA	ICGC	PPPY	ITCH	423:426	Mutation rewiring degron network	0.2778
p.R313C	DO233852	GACA	ICGC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1389
p.P470L	DO13192	GBM	ICGC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.P470L	DO223286	UCEC	ICGC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.P470Q	DO15759	HNSC	ICGC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.R357M	DO228948	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0556
p.M480I	DO228974	LICA	ICGC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2222
p.W365L	DO228971	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2778
p.W365L	DO229027	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2778
p.V242F	DO229018	LICA	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation altering degron motif	0.7068
p.G475V	DO229018	LICA	ICGC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7532
p.W365C	DO229027	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2778
p.V327L	DO229036	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.25
p.M476I	DO229037	LICA	ICGC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7618
p.S361P	DO50857	LIRI	ICGC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1667
p.L424F	DO229101	LMS	ICGC	PPPY	ITCH	423:426	Mutation altering degron motif	0.6981
p.Q377E	DO23742	LUAD	ICGC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1944
p.R313L	DO45386	LUAD	ICGC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1389
p.S315I	DO45527	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1944
p.Q246K	DO28923	OV	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.2778
p.Q246K	DO37405	SKCM	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.2778
p.G479S	DO232224	PBCA	ICGC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.25
p.R426S	DO232532	PBCA	ICGC	PPPY	ITCH	423:426	Mutation altering degron motif	0.7427
p.R426S	ACH-000030	Lung Cancer	CCLE	PPPY	ITCH	423:426	Mutation altering degron motif	0.7427
p.R426S	ACH-000488	Esophageal Cancer	CCLE	PPPY	ITCH	423:426	Mutation altering degron motif	0.7427
p.R426S	ACH-000761	Gastric Cancer	CCLE	PPPY	ITCH	423:426	Mutation altering degron motif	0.7427
p.R426S	ACH-000777	Esophageal Cancer	CCLE	PPPY	ITCH	423:426	Mutation altering degron motif	0.7427
p.R319H	DO51407	PRAD	ICGC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.R319H	DO41422	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.D252N	DO36881	READ	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.1111
p.D252N	DO42713	UCEC	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.1111
p.A413D	DO46824	RECA	ICGC	PPPY	ITCH	423:426	Mutation rewiring degron network	0.0556
p.D22N	DO51235	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1389
p.P364S	DO51783	STAD	ICGC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.T379M	DO51761	STAD	ICGC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1389
p.T483A	DO48009	STAD	ICGC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1389
p.M378T	DO42023	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation blocking phosphorylation signal	0.6111
p.S34F	DO223286	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.V329A	DO42256	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1944
p.N231K	DO43041	UCEC	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.1389
p.R319C	DO43186	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.L478F	DO41871	UCEC	ICGC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.S322F	SIDM01954	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7982
p.V417I	SIDM01308	Esophageal Carcinoma	GDSC	PPPY	ITCH	423:426	Mutation rewiring degron network	0.1667
p.N486Y	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.N486Y	ACH-000432	Leukemia	CCLE	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.N486Y	BV-173	haematopoietic and lymphoid tissue	COSMIC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.A465G	SIDM00525	Osteosarcoma	GDSC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation blocking phosphorylation signal	0.5833
p.G363A	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2222
p.G363A	NCI-H358	lung	COSMIC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2222
p.R229G	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.0833
p.R229G	NCI-H1651	lung	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.0833
p.P253L	SIDM00928	Breast Carcinoma	GDSC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.0833
p.P253L	ACH-000857	Breast Cancer	CCLE	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.0833
p.P253L	CAL-85-1	breast	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.0833
p.T327N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.25
p.T327N	ACH-000945	Lung Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.25
p.T327N	NCI-H650	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.25
p.S32R	SIDM00875	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7427
p.S32R	ACH-000624	Breast Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7427
p.S32R	HCC1806	breast	COSMIC	PPSSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7427
p.Q433H	SIDM00927	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	423:426	Mutation rewiring degron network	0.1389
p.Q433H	ACH-000871	Lung Cancer	CCLE	PPPY	ITCH	423:426	Mutation rewiring degron network	0.1389
p.Q433H	NCI-H510A	lung	COSMIC	PPPY	ITCH	423:426	Mutation rewiring degron network	0.1389
p.R228S	SIDM00537	Colorectal Carcinoma	GDSC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.0556
p.R228S	GP5d	large intestine	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.0556
p.S415T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PPPY	ITCH	423:426	Mutation rewiring degron network	0.1111
p.L483S	ACH-001610	Brain Cancer	CCLE	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1389
p.P425L	ACH-002396	Bone Cancer	CCLE	PPPY	ITCH	423:426	Mutation altering degron motif	0.6471
p.P425L	Sarc9371	bone	COSMIC	PPPY	ITCH	423:426	Mutation altering degron motif	0.6471
p.V245A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.3056
p.P424L	A388	skin	COSMIC	PPPY	ITCH	423:426	Mutation altering degron motif	0.7582
p.P239L	CAL-85-1	breast	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation altering degron motif	0.6471
p.N464Y	BV-173	haematopoietic and lymphoid tissue	COSMIC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1111
p.H371R	IPC-298	skin	COSMIC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.8244
p.H379R	IPC-298	skin	COSMIC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1389
p.G430A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	423:426	Mutation rewiring degron network	0.2222
p.G327A	NCI-H358	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.25
p.T313N	NCI-H650	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1389
p.Q419H	NCI-H510A	lung	COSMIC	PPPY	ITCH	423:426	Mutation rewiring degron network	0.2222
p.Q250K	NCI-H727	lung	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	238:244	Mutation rewiring degron network	0.1667
p.R324H	SCC-15	upper aerodigestive tract	COSMIC	PLSST	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.8244
p.H357R	IPC-298	skin	COSMIC	LGPFSD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0556
p.G416A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	423:426	Mutation rewiring degron network	0.1389
p.N472Y	BV-173	haematopoietic and lymphoid tissue	COSMIC	PCTTT	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7059

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RUNX2

UniProt ID: Q13950

Entrez ID: 860

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RUNX2 in