DegronMD

Uniprot ID: Q13950

Source protein: Runt-related transcription factor 2

Source gene: RUNX2

Class: LIG_APCC_ABBA_1

Location: 367:372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9066

ASA_SCORE: 65.5833

COIL: 0.8845

CONS_SCORE: 0.3007

DSS_SCORE: 0.5454

HELIX: 0.0635

FCONS_SCORE: 1.0649

RIG_SCORE: 0.6527

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P373R	TCGA-AR-A24Q	BRCA	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.3056
p.D372V	TCGA-VR-A8ER	ESCA	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.7785
p.S380F	DO6308	CESC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1111
p.P372R	DO52438	COCA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.7512
p.R357M	DO228948	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.0556
p.W365L	DO228971	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.2778
p.W365L	DO229027	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.2778
p.W365C	DO229027	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.2778
p.S361P	DO50857	LIRI	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1667
p.Q377E	DO23742	LUAD	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1944
p.P364S	DO51783	STAD	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.25
p.T379M	DO51761	STAD	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1389
p.M378T	DO42023	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.6111
p.G363A	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.G363A	NCI-H358	lung	COSMIC	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.H371R	IPC-298	skin	COSMIC	LGPFSD	LIG_APCC_ABBA_1	0.8244
p.H379R	IPC-298	skin	COSMIC	LGPFSD	LIG_APCC_ABBA_1	0.1389
p.H357R	IPC-298	skin	COSMIC	LGPFSD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07333	Macrophage colony-stimulating factor 1 receptor	LIG_APCC_ABBA_1	339:344	LGPFSD	APC,CDC20,FZR1	0.926	More...
Q13950	Runt-related transcription factor 2	LIG_APCC_ABBA_1	367:372	LGPFSD	APC,CDC20,FZR1	0.9066	More...
Q9ULB5	Cadherin-7	LIG_APCC_ABBA_1	355:360	LGPFSD	APC,CDC20,FZR1	0.9255	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons