DegronMD

Uniprot ID: Q9ULB5

Source protein: Cadherin-7

Source gene: CDH7

Class: LIG_APCC_ABBA_1

Location: 355:360

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9255

ASA_SCORE: 58.65

COIL: 0.7652

CONS_SCORE: 0.746

DSS_SCORE: 0.2782

HELIX: 0.0282

FCONS_SCORE: 1.0788

RIG_SCORE: 0.717

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P357L	TCGA-30-1857	OV	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.6471
p.P357L	DO28491	OV	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.6471
p.D349Y	TCGA-63-A5MV	LUSC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.1667
p.D349Y	DO219167	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1667
p.R351H	TCGA-85-7698	LUSC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.R351H	TCGA-YZ-A985	UVM	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.R351H	DO27723	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.R351H	DO232761	PBCA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.R351H	SIDM00721	Small Cell Lung Carcinoma	GDSC	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.R351H	ACH-002171	Lung Cancer	CCLE	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.R351H	NCI-H250	lung	COSMIC	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.V364M	TCGA-AP-A051	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.V364M	DO42673	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.T363S	TCGA-BK-A139	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.25
p.T363S	DO41716	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.25
p.D370Y	TCGA-BR-8080	STAD	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.0556
p.D370Y	DO38651	STAD	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.0556
p.P357S	TCGA-DF-A2KU	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.6752
p.P357S	TCGA-FS-A4FD	SKCM	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.6752
p.P357S	TCGA-WE-AAA0	SKCM	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.6752
p.P357S	DO37699	SKCM	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.6752
p.P357S	DO51294	SKCM	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.6752
p.P357S	DO223286	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.6752
p.P357S	ACH-002055	Lymphoma	CCLE	LGPFSD	LIG_APCC_ABBA_1	0.6752
p.D347Y	TCGA-EY-A1G8	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.1111
p.D347Y	DO43578	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1111
p.D349N	TCGA-EY-A1GK	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.1667
p.D349N	DO42985	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1667
p.A348V	TCGA-QF-A5YS	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.1389
p.A348V	DO52426	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1389
p.D349H	DO233622	GACA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1667
p.D349V	DO233865	GACA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1667
p.A348S	DO228924	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1389
p.S354I	DO229045	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.3056
p.S354I	DO230918	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.3056
p.S354I	DO224546	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.3056
p.G356V	DO229006	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.6421
p.R351G	DO231824	LINC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.2222
p.F352I	DO45047	LINC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.25
p.L355F	DO230918	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.587
p.L355F	DO224546	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.587
p.D360E	DO231091	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.5647
p.T362R	SIDM01186	Breast Carcinoma	GDSC	LGPFSD	LIG_APCC_ABBA_1	0.2778
p.T362R	ACH-000554	Breast Cancer	CCLE	LGPFSD	LIG_APCC_ABBA_1	0.2778
p.T362R	UACC-893	breast	COSMIC	LGPFSD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07333	Macrophage colony-stimulating factor 1 receptor	LIG_APCC_ABBA_1	339:344	LGPFSD	APC,CDC20,FZR1	0.926	More...
Q13950	Runt-related transcription factor 2	LIG_APCC_ABBA_1	367:372	LGPFSD	APC,CDC20,FZR1	0.9066	More...
Q9ULB5	Cadherin-7	LIG_APCC_ABBA_1	355:360	LGPFSD	APC,CDC20,FZR1	0.9255	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGPFSD

Degron related mutations and impact score

Drug responses associated with CDH7 mutations

All proteins holding degron of LGPFSD