DegronMD - Q9ULB5(CDH7)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P357L	TCGA-30-1857	OV	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6471
p.P357L	DO28491	OV	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6471
p.D349Y	TCGA-63-A5MV	LUSC	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1667
p.D349Y	DO219167	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1667
p.R351H	TCGA-85-7698	LUSC	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.R351H	TCGA-YZ-A985	UVM	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.R351H	DO27723	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.R351H	DO232761	PBCA	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.R351H	SIDM00721	Small Cell Lung Carcinoma	GDSC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.R351H	ACH-002171	Lung Cancer	CCLE	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.R351H	NCI-H250	lung	COSMIC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.V364M	TCGA-AP-A051	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.V364M	DO42673	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.T363S	TCGA-BK-A139	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.25
p.T363S	DO41716	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.25
p.D370Y	TCGA-BR-8080	STAD	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0556
p.D370Y	DO38651	STAD	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0556
p.P357S	TCGA-DF-A2KU	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6752
p.P357S	TCGA-FS-A4FD	SKCM	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6752
p.P357S	TCGA-WE-AAA0	SKCM	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6752
p.P357S	DO37699	SKCM	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6752
p.P357S	DO51294	SKCM	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6752
p.P357S	DO223286	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6752
p.P357S	ACH-002055	Lymphoma	CCLE	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6752
p.D347Y	TCGA-EY-A1G8	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1111
p.D347Y	DO43578	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1111
p.D349N	TCGA-EY-A1GK	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1667
p.D349N	DO42985	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1667
p.A348V	TCGA-QF-A5YS	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1389
p.A348V	DO52426	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1389
p.D349H	DO233622	GACA	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1667
p.D349V	DO233865	GACA	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1667
p.A348S	DO228924	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1389
p.S354I	DO229045	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.3056
p.S354I	DO230918	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.3056
p.S354I	DO224546	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.3056
p.G356V	DO229006	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6421
p.R351G	DO231824	LINC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.F352I	DO45047	LINC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.25
p.L355F	DO230918	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.587
p.L355F	DO224546	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.587
p.D360E	DO231091	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.5647
p.T362R	SIDM01186	Breast Carcinoma	GDSC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2778
p.T362R	ACH-000554	Breast Cancer	CCLE	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2778
p.T362R	UACC-893	breast	COSMIC	LGPFSD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2778

Kaplan plot for CDH7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH7

UniProt ID: Q9ULB5

Entrez ID: 1005

Protein name: Cadherin-7

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH7 in