DegronMD

Uniprot ID: P07333

Source protein: Macrophage colony-stimulating factor 1 receptor

Source gene: CSF1R

Class: LIG_APCC_ABBA_1

Location: 339:344

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.926

ASA_SCORE: 68.7833

COIL: 0.737

CONS_SCORE: 0.2758

DSS_SCORE: 0.3461

HELIX: 0.0337

FCONS_SCORE: 0.9618

RIG_SCORE: 0.7499

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A354P	TCGA-60-2719	LUSC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.0556
p.A354P	DO27453	LUSC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.0556
p.A352G	TCGA-AJ-A2QO	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.1111
p.A352G	DO42177	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1111
p.S343Y	TCGA-EO-A3B0	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.6009
p.S343Y	DO219773	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.6009
p.L351P	TCGA-EY-A215	UCEC	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.1389
p.L351P	DO42665	UCEC	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1389
p.A354D	TCGA-J2-8194	LUAD	TCGA	LGPFSD	LIG_APCC_ABBA_1	0.0556
p.A354D	DO23971	LUAD	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.0556
p.G340V	DO1158	BRCA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.6421
p.P341T	DO229024	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.7031
p.A352D	DO229026	LICA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1111
p.G333D	DO220913	MELA	ICGC	LGPFSD	LIG_APCC_ABBA_1	0.1667

Drug responses associated with CSF1R mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00762	LUAD\|lung_NSCLC_adenocarcinoma	p.E920D (No)	GDSC	GW-2580	222.5638
SIDM00762	LUAD\|lung_NSCLC_adenocarcinoma	p.E920D (No)	GDSC	Pazopanib	6.1643
SIDM00762	LUAD\|lung_NSCLC_adenocarcinoma	p.E920D (No)	GDSC	Linifanib	11.7708
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.A792P (No)	GDSC	GW-2580	183.0488
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.A792P (No)	GDSC	Linifanib	9.4209
SIDM01032	ESCA\|oesophagus	p.H623Y (No)	GDSC	GW-2580	466.7977
SIDM01032	ESCA\|oesophagus	p.H623Y (No)	GDSC	Pazopanib	118.5109
SIDM01032	ESCA\|oesophagus	p.H623Y (No)	GDSC	Linifanib	27.0999
SIDM00382	GBM\|glioma	p.E920D (No)	GDSC	Sunitinib	2.6505
SIDM00382	GBM\|glioma	p.E920D (No)	GDSC	GW-2580	267.2106
SIDM00382	GBM\|glioma	p.E920D (No)	GDSC	Pazopanib	3.0068
SIDM00382	GBM\|glioma	p.E920D (No)	GDSC	Linifanib	14.057
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.P202S (No)	GDSC	Sunitinib	20.9013
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.P202S (No)	GDSC	GW-2580	114.8835
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.P202S (No)	GDSC	Pazopanib	47.1881
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.P202S (No)	GDSC	Linifanib	11.1077
SIDM00940	BRCA\|breast	p.R106Q (No)	GDSC	GW-2580	440.0921
SIDM00940	BRCA\|breast	p.R106Q (No)	GDSC	Pazopanib	20.2904
SIDM00940	BRCA\|breast	p.R106Q (No)	GDSC	Linifanib	21.8688
SIDM00781	COREAD\|large_intestine	p.P402fs*3 (No)	GDSC	Sunitinib	64.3744
SIDM00781	COREAD\|large_intestine	p.P402fs*3 (No)	GDSC	GW-2580	332.3591
SIDM00781	COREAD\|large_intestine	p.P402fs*3 (No)	GDSC	Pazopanib	34.8312
SIDM00781	COREAD\|large_intestine	p.P402fs*3 (No)	GDSC	Linifanib	19.5153
SIDM00989	BLCA\|bladder	p.S937_S938insGS (No)	GDSC	GW-2580	131.6997
SIDM00989	BLCA\|bladder	p.S937_S938insGS (No)	GDSC	Pazopanib	27.8581
SIDM00989	BLCA\|bladder	p.S937_S938insGS (No)	GDSC	Linifanib	9.0538
SIDM00250	ESCA\|oesophagus	p.V315L (No)	GDSC	GW-2580	118.6695
SIDM00250	ESCA\|oesophagus	p.V315L (No)	GDSC	Linifanib	7.7997
SIDM00250	ESCA\|oesophagus	p.R106L (No)	GDSC	GW-2580	118.6695
SIDM00250	ESCA\|oesophagus	p.R106L (No)	GDSC	Linifanib	7.7997
SIDM01007	ALL\|lymphoblastic_leukemia	p.E920D (No)	GDSC	Sunitinib	2.0565
SIDM01007	ALL\|lymphoblastic_leukemia	p.E920D (No)	GDSC	GW-2580	122.3043
SIDM01007	ALL\|lymphoblastic_leukemia	p.E920D (No)	GDSC	Pazopanib	9.0608
SIDM01007	ALL\|lymphoblastic_leukemia	p.E920D (No)	GDSC	Linifanib	4.2428
SIDM01007	ALL\|lymphoblastic_leukemia	p.S188P (No)	GDSC	Sunitinib	2.0565
SIDM01007	ALL\|lymphoblastic_leukemia	p.S188P (No)	GDSC	GW-2580	122.3043
SIDM01007	ALL\|lymphoblastic_leukemia	p.S188P (No)	GDSC	Pazopanib	9.0608
SIDM01007	ALL\|lymphoblastic_leukemia	p.S188P (No)	GDSC	Linifanib	4.2428
SIDM00341	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G747R (No)	GDSC	GW-2580	221.1102
SIDM00341	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G747R (No)	GDSC	Pazopanib	70.1185
SIDM00341	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G747R (No)	GDSC	Linifanib	15.185
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.G714S (No)	GDSC	GW-2580	602.9354
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.G714S (No)	GDSC	Pazopanib	30.7626
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.G714S (No)	GDSC	Linifanib	33.9703
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.P517T (No)	GDSC	GW-2580	602.9354
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.P517T (No)	GDSC	Pazopanib	30.7626
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.P517T (No)	GDSC	Linifanib	33.9703
SIDM00389	DLBC\|B_cell_lymphoma	p.T600M (No)	GDSC	GW-2580	64.6601
SIDM00389	DLBC\|B_cell_lymphoma	p.T600M (No)	GDSC	Linifanib	3.3062
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.E944Q (No)	GDSC	Sunitinib	24.1348
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.E944Q (No)	GDSC	GW-2580	219.2924
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.E944Q (No)	GDSC	Pazopanib	80.8409
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.E944Q (No)	GDSC	Linifanib	8.7117
SIDM00690	HNSC\|head_and_neck	p.A105V (No)	GDSC	Pazopanib	16.1392
SIDM00504	LGG\|glioma	p.R710H (No)	GDSC	GW-2580	168.8441
SIDM00504	LGG\|glioma	p.R710H (No)	GDSC	Pazopanib	5.8301
SIDM00504	LGG\|glioma	p.R710H (No)	GDSC	Linifanib	10.2191
SIDM01028	ESCA\|oesophagus	p.G589E (No)	GDSC	GW-2580	306.1414
SIDM01028	ESCA\|oesophagus	p.G589E (No)	GDSC	Pazopanib	41.2747
SIDM01028	ESCA\|oesophagus	p.G589E (No)	GDSC	Linifanib	10.5921
SIDM01028	ESCA\|oesophagus	p.D358N (No)	GDSC	GW-2580	306.1414
SIDM01028	ESCA\|oesophagus	p.D358N (No)	GDSC	Pazopanib	41.2747
SIDM01028	ESCA\|oesophagus	p.D358N (No)	GDSC	Linifanib	10.5921
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.R753W (No)	GDSC	GW-2580	229.419
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.R753W (No)	GDSC	Pazopanib	17.8762
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.R753W (No)	GDSC	Linifanib	12.797
SIDM00333	UCEC\|endometrium	p.E920D (No)	GDSC	GW-2580	191.2664
SIDM00333	UCEC\|endometrium	p.E920D (No)	GDSC	Pazopanib	9.3119
SIDM00333	UCEC\|endometrium	p.E920D (No)	GDSC	Linifanib	10.7273
SIDM00630	BRCA\|breast	p.Q970* (No)	GDSC	GW-2580	150.6293
SIDM00630	BRCA\|breast	p.Q970* (No)	GDSC	Pazopanib	12.1881
SIDM00630	BRCA\|breast	p.Q970* (No)	GDSC	Linifanib	29.1021
SIDM00256	NB\|neuroblastoma	p.R256H (No)	GDSC	Sunitinib	13.3482
SIDM00256	NB\|neuroblastoma	p.R256H (No)	GDSC	GW-2580	164.9445
SIDM00256	NB\|neuroblastoma	p.R256H (No)	GDSC	Pazopanib	76.5042
SIDM00256	NB\|neuroblastoma	p.R256H (No)	GDSC	Linifanib	9.7888
SIDM00507	UNCLASSIFIED\|lung_other	p.R710H (No)	GDSC	GW-2580	240.0857
SIDM00507	UNCLASSIFIED\|lung_other	p.R710H (No)	GDSC	Linifanib	7.0198
SIDM00217	COREAD\|large_intestine	p.A960T (No)	GDSC	GW-2580	549.1068
SIDM00217	COREAD\|large_intestine	p.A960T (No)	GDSC	Linifanib	18.1376
SIDM00821	KIRC\|kidney	p.G413S (No)	GDSC	GW-2580	122.8845
SIDM00821	KIRC\|kidney	p.G413S (No)	GDSC	Linifanib	13.192
SIDM00140	SKCM\|melanoma	p.A14T (No)	GDSC	GW-2580	213.2058
SIDM00140	SKCM\|melanoma	p.A14T (No)	GDSC	Pazopanib	132.4034
SIDM00140	SKCM\|melanoma	p.A14T (No)	GDSC	Linifanib	13.1936
SIDM00216	COREAD\|large_intestine	p.G145D (No)	GDSC	GW-2580	77.9074
SIDM00216	COREAD\|large_intestine	p.G145D (No)	GDSC	Linifanib	6.5206
SIDM00396	LAML\|acute_myeloid_leukaemia	p.G413S (No)	GDSC	Sunitinib	1.4723
SIDM00396	LAML\|acute_myeloid_leukaemia	p.G413S (No)	GDSC	GW-2580	33.529
SIDM00396	LAML\|acute_myeloid_leukaemia	p.G413S (No)	GDSC	Pazopanib	23.4407
SIDM00396	LAML\|acute_myeloid_leukaemia	p.G413S (No)	GDSC	Linifanib	3.7764
SIDM01057	LAML\|acute_myeloid_leukaemia	p.Y571D (No)	GDSC	GW-2580	0.1572
SIDM01057	LAML\|acute_myeloid_leukaemia	p.Y571D (No)	GDSC	Pazopanib	0.1913
SIDM01057	LAML\|acute_myeloid_leukaemia	p.Y571D (No)	GDSC	Linifanib	0.0068
SIDM01006	MM\|haematopoietic_neoplasm_other	p.V32G (No)	GDSC	Sunitinib	2.6422
SIDM01006	MM\|haematopoietic_neoplasm_other	p.V32G (No)	GDSC	GW-2580	151.0743
SIDM01006	MM\|haematopoietic_neoplasm_other	p.V32G (No)	GDSC	Pazopanib	61.5764
SIDM01006	MM\|haematopoietic_neoplasm_other	p.V32G (No)	GDSC	Linifanib	7.3062
SIDM00973	SKCM\|melanoma	p.G413S (No)	GDSC	GW-2580	259.1536
SIDM00973	SKCM\|melanoma	p.G413S (No)	GDSC	Pazopanib	7.634
SIDM00973	SKCM\|melanoma	p.G413S (No)	GDSC	Linifanib	10.3882
SIDM00673	BRCA\|breast	p.P510A (No)	GDSC	GW-2580	288.5063
SIDM00673	BRCA\|breast	p.P510A (No)	GDSC	Pazopanib	19.2114
SIDM00673	BRCA\|breast	p.P510A (No)	GDSC	Linifanib	11.3311
SIDM00257	NB\|neuroblastoma	p.Q460H (No)	GDSC	Sunitinib	12.0582
SIDM00257	NB\|neuroblastoma	p.Q460H (No)	GDSC	GW-2580	131.1493
SIDM00257	NB\|neuroblastoma	p.Q460H (No)	GDSC	Pazopanib	45.2117
SIDM00257	NB\|neuroblastoma	p.Q460H (No)	GDSC	Linifanib	5.3165
SIDM00534	COREAD\|large_intestine	p.V659A (No)	GDSC	GW-2580	144.7652
SIDM00534	COREAD\|large_intestine	p.V659A (No)	GDSC	Pazopanib	34.3026
SIDM00534	COREAD\|large_intestine	p.V659A (No)	GDSC	Linifanib	13.547
SIDM00607	LGG\|glioma	p.L853fs*1 (No)	GDSC	Sunitinib	88.7242
SIDM00607	LGG\|glioma	p.L853fs*1 (No)	GDSC	GW-2580	350.9557
SIDM00607	LGG\|glioma	p.L853fs*1 (No)	GDSC	Pazopanib	19.8284
SIDM00607	LGG\|glioma	p.L853fs*1 (No)	GDSC	Linifanib	15.7847
SIDM00149	SKCM\|melanoma	p.C972Y (No)	GDSC	Sunitinib	9.6513
SIDM00149	SKCM\|melanoma	p.C972Y (No)	GDSC	GW-2580	194.0217
SIDM00149	SKCM\|melanoma	p.C972Y (No)	GDSC	Pazopanib	18.9412
SIDM00149	SKCM\|melanoma	p.C972Y (No)	GDSC	Linifanib	9.5787
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.D89N (No)	GDSC	Sunitinib	3.3217
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.D89N (No)	GDSC	GW-2580	223.7135
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.D89N (No)	GDSC	Pazopanib	6.5834
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.D89N (No)	GDSC	Linifanib	11.7475
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G690S (No)	GDSC	GW-2580	160.8699
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G690S (No)	GDSC	Pazopanib	5.4155
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G690S (No)	GDSC	Linifanib	10.9623
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E664G (No)	GDSC	GW-2580	74.9887
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E664G (No)	GDSC	Pazopanib	2.1302
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E664G (No)	GDSC	Linifanib	17.2615
SIDM00114	MESO\|mesothelioma	p.M726I (No)	GDSC	GW-2580	599.4473
SIDM00114	MESO\|mesothelioma	p.M726I (No)	GDSC	Pazopanib	23.2662
SIDM00114	MESO\|mesothelioma	p.M726I (No)	GDSC	Linifanib	14.9174
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.I827N (No)	GDSC	GW-2580	379.0386
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.I827N (No)	GDSC	Pazopanib	78.6061
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.I827N (No)	GDSC	Linifanib	10.021
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V138I (No)	GDSC	Sunitinib	2.8236
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V138I (No)	GDSC	GW-2580	192.1361
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V138I (No)	GDSC	Pazopanib	27.7744
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V138I (No)	GDSC	Linifanib	9.659
SIDM00285	NB\|neuroblastoma	p.R486S (No)	GDSC	GW-2580	216.7997
SIDM00285	NB\|neuroblastoma	p.R486S (No)	GDSC	Linifanib	13.206
SIDM01170	OV\|ovary	p.G413S (No)	GDSC	GW-2580	186.1337
SIDM01170	OV\|ovary	p.G413S (No)	GDSC	Pazopanib	4.2582
SIDM01170	OV\|ovary	p.G413S (No)	GDSC	Linifanib	6.3881
SIDM00537	COREAD\|large_intestine	p.G377D (No)	GDSC	GW-2580	137.7785
SIDM00537	COREAD\|large_intestine	p.G377D (No)	GDSC	Pazopanib	34.5022
SIDM00537	COREAD\|large_intestine	p.G377D (No)	GDSC	Linifanib	0.9776
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.L207P (No)	GDSC	GW-2580	250.1971
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.L207P (No)	GDSC	Pazopanib	65.7082
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.L207P (No)	GDSC	Linifanib	9.1717
SIDM00333	UCEC\|endometrium	p.R579fs*33 (No)	GDSC	GW-2580	191.2664
SIDM00333	UCEC\|endometrium	p.R579fs*33 (No)	GDSC	Pazopanib	9.3119
SIDM00333	UCEC\|endometrium	p.R579fs*33 (No)	GDSC	Linifanib	10.7273
SIDM00796	UNCLASSIFIED\|head_and_neck	p.E694K (No)	GDSC	Sunitinib	70.9982
SIDM00796	UNCLASSIFIED\|head_and_neck	p.E694K (No)	GDSC	GW-2580	233.6894
SIDM00796	UNCLASSIFIED\|head_and_neck	p.E694K (No)	GDSC	Pazopanib	6.5195
SIDM00796	UNCLASSIFIED\|head_and_neck	p.E694K (No)	GDSC	Linifanib	11.5524

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07333	Macrophage colony-stimulating factor 1 receptor	LIG_APCC_ABBA_1	339:344	LGPFSD	APC,CDC20,FZR1	0.926	More...
Q13950	Runt-related transcription factor 2	LIG_APCC_ABBA_1	367:372	LGPFSD	APC,CDC20,FZR1	0.9066	More...
Q9ULB5	Cadherin-7	LIG_APCC_ABBA_1	355:360	LGPFSD	APC,CDC20,FZR1	0.9255	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGPFSD

Degron related mutations and impact score

Drug responses associated with CSF1R mutations

All proteins holding degron of LGPFSD