DegronMD

Uniprot ID: Q13950

Source protein: Runt-related transcription factor 2

Source gene: RUNX2

Class: DEG_SPOP_SBC_1

Location: 472:476

E3 ligase: SPOP

DEGRON score: 0.9948

ASA_SCORE: 76.64

COIL: 0.894

CONS_SCORE: 0.2448

DSS_SCORE: 0.6381

HELIX: 0.0298

FCONS_SCORE: 0.8254

RIG_SCORE: 0.6869

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T481M	TCGA-19-2621	GBM	TCGA	PCTTT	DEG_SPOP_SBC_1	0.1944
p.S477L	TCGA-D1-A17Q	UCEC	TCGA	PCTTT	DEG_SPOP_SBC_1	0.3056
p.S477L	SIDM01588	Endometrial Carcinoma	GDSC	PCTTT	DEG_SPOP_SBC_1	0.3056
p.S477L	ACH-000993	Endometrial/Uterine Cancer	CCLE	PCTTT	DEG_SPOP_SBC_1	0.3056
p.T476N	TCGA-EY-A1GU	UCEC	TCGA	PCTTT	DEG_SPOP_SBC_1	0.7055
p.P466S	TCGA-FS-A1ZK	SKCM	TCGA	PCTTT	DEG_SPOP_SBC_1	0.1667
p.T476I	TCGA-IB-7651	PAAD	TCGA	PCTTT	DEG_SPOP_SBC_1	0.7078
p.P470L	DO13192	GBM	ICGC	PCTTT	DEG_SPOP_SBC_1	0.2778
p.P470L	DO223286	UCEC	ICGC	PCTTT	DEG_SPOP_SBC_1	0.2778
p.P470Q	DO15759	HNSC	ICGC	PCTTT	DEG_SPOP_SBC_1	0.2778
p.M480I	DO228974	LICA	ICGC	PCTTT	DEG_SPOP_SBC_1	0.2222
p.G475V	DO229018	LICA	ICGC	PCTTT	DEG_SPOP_SBC_1	0.7532
p.M476I	DO229037	LICA	ICGC	PCTTT	DEG_SPOP_SBC_1	0.7618
p.G479S	DO232224	PBCA	ICGC	PCTTT	DEG_SPOP_SBC_1	0.25
p.T483A	DO48009	STAD	ICGC	PCTTT	DEG_SPOP_SBC_1	0.1389
p.L478F	DO41871	UCEC	ICGC	PCTTT	DEG_SPOP_SBC_1	0.2778
p.N486Y	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PCTTT	DEG_SPOP_SBC_1	0.0556
p.N486Y	ACH-000432	Leukemia	CCLE	PCTTT	DEG_SPOP_SBC_1	0.0556
p.N486Y	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	PCTTT	DEG_SPOP_SBC_1	0.0556
p.A465G	SIDM00525	Osteosarcoma	GDSC	PCTTT	DEG_SPOP_SBC_1	0.5833
p.L483S	ACH-001610	Brain Cancer	CCLE	PCTTT	DEG_SPOP_SBC_1	0.1389
p.N464Y	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	PCTTT	DEG_SPOP_SBC_1	0.1111
p.N472Y	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	PCTTT	DEG_SPOP_SBC_1	0.7059

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13950	Runt-related transcription factor 2	DEG_SPOP_SBC_1	472:476	PCTTT	SPOP	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons