DegronMD

Uniprot ID: Q13950

Source protein: Runt-related transcription factor 2

Source gene: RUNX2

Class: LIG_APCC_ABBAyCdc20_2

Location: 238:244

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8937

ASA_SCORE: 62

COIL: 0.7623

CONS_SCORE: 0.265

DSS_SCORE: 0.6122

HELIX: 0.1766

FCONS_SCORE: 0.7569

RIG_SCORE: 0.6702

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S247I	TCGA-56-7731	LUSC	TCGA	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.6944
p.R245L	TCGA-97-A4M7	LUAD	TCGA	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R251C	TCGA-AP-A1DV	UCEC	TCGA	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R251H	TCGA-AX-A1C5	UCEC	TCGA	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R251H	TCGA-XK-AAIW	PRAD	TCGA	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R237Q	DO2937	BRCA	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.75
p.R237Q	DO222628	MELA	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.75
p.R237Q	DO37539	SKCM	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.75
p.R254I	DO2401	BRCA	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R237W	DO10020	COAD	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.75
p.D229N	DO9876	COAD	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V242F	DO229018	LICA	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.7068
p.Q246K	DO28923	OV	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q246K	DO37405	SKCM	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D252N	DO36881	READ	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D252N	DO42713	UCEC	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.N231K	DO43041	UCEC	ICGC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R229G	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R229G	NCI-H1651	lung	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P253L	SIDM00928	Breast Carcinoma	GDSC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P253L	ACH-000857	Breast Cancer	CCLE	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P253L	CAL-85-1	breast	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R228S	SIDM00537	Colorectal Carcinoma	GDSC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R228S	GP5d	large_intestine	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.V245A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P239L	CAL-85-1	breast	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.6471
p.Q250K	NCI-H727	lung	COSMIC	KPSLFSD	LIG_APCC_ABBAyCdc20_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KPSLFSD

Degron related mutations and impact score

Drug responses associated with RUNX2 mutations

All proteins holding degron of KPSLFSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13950	Runt-related transcription factor 2	LIG_APCC_ABBAyCdc20_2	238:244	KPSLFSD	APC,CDC20,FZR1	0.8937	More...