DegronMD - Q96J86(CYYR1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P130L	TCGA-06-5416	GBM	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.6471
p.P130L	TCGA-06-5416	GBM	TCGA	PPPY	ITCH	129:132	Mutation altering degron motif	0.7582
p.P130L	DO10880	GBM	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.6471
p.P130L	DO10880	GBM	ICGC	PPPY	ITCH	129:132	Mutation altering degron motif	0.7582
p.R153K	TCGA-17-Z055	LUAD	TCGA	PPPY	ITCH	145:148	Mutation rewiring degron network	0.1944
p.R153K	TCGA-EE-A2GR	SKCM	TCGA	PPPY	ITCH	145:148	Mutation rewiring degron network	0.1944
p.R153K	DO37996	SKCM	ICGC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.1944
p.P131S	TCGA-19-5956	GBM	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.5641
p.P131S	TCGA-19-5956	GBM	TCGA	PPPY	ITCH	129:132	Mutation altering degron motif	0.5641
p.P131S	DO13863	GBM	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.5641
p.P131S	DO13863	GBM	ICGC	PPPY	ITCH	129:132	Mutation altering degron motif	0.5641
p.D119Y	TCGA-2Y-A9GW	LIHC	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1111
p.D119Y	TCGA-2Y-A9GW	LIHC	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.25
p.D119Y	TCGA-2Y-A9GW	LIHC	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.D119Y	DO219511	LIHC	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1111
p.D119Y	DO219511	LIHC	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.25
p.D119Y	DO219511	LIHC	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.N151K	TCGA-43-2581	LUSC	TCGA	PPPY	ITCH	145:148	Mutation rewiring degron network	0.25
p.N151K	DO228986	LICA	ICGC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.25
p.N151K	DO26602	LUSC	ICGC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.25
p.E123K	TCGA-55-6980	LUAD	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.2222
p.E123K	TCGA-55-6980	LUAD	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1389
p.E123K	TCGA-55-6980	LUAD	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1667
p.E123K	DO25518	LUAD	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.2222
p.E123K	DO25518	LUAD	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1389
p.E123K	DO25518	LUAD	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1667
p.P147T	TCGA-61-1998	OV	TCGA	PPPY	ITCH	145:148	Mutation altering degron motif	0.5919
p.P147T	DO28813	OV	ICGC	PPPY	ITCH	145:148	Mutation altering degron motif	0.5919
p.P147T	SIDM00060	Ovarian Carcinoma	GDSC	PPPY	ITCH	145:148	Mutation altering degron motif	0.5919
p.T135N	TCGA-95-7567	LUAD	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.5944
p.T135N	DO25564	LUAD	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.5944
p.D119V	TCGA-AJ-A3EK	UCEC	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1111
p.D119V	TCGA-AJ-A3EK	UCEC	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.25
p.D119V	TCGA-AJ-A3EK	UCEC	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.D119V	DO41584	UCEC	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1111
p.D119V	DO41584	UCEC	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.25
p.D119V	DO41584	UCEC	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.P147L	TCGA-BR-7851	STAD	TCGA	PPPY	ITCH	145:148	Mutation altering degron motif	0.6471
p.P147L	DO38711	STAD	ICGC	PPPY	ITCH	145:148	Mutation altering degron motif	0.6471
p.L128M	TCGA-BS-A0UJ	UCEC	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.5999
p.L128M	DO42745	UCEC	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.5999
p.G112E	TCGA-D9-A4Z6	SKCM	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.3056
p.G112E	DO47485	SKCM	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.3056
p.T106A	TCGA-E7-A4IJ	BLCA	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1389
p.T106A	DO453	BLCA	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1389
p.P136S	TCGA-EE-A2GN	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.6752
p.P136S	DO37896	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.6752
p.E121K	TCGA-ER-A19S	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1667
p.E121K	TCGA-ER-A19S	SKCM	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1944
p.E121K	TCGA-ER-A19S	SKCM	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1111
p.E121K	TCGA-YD-A89C	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1667
p.E121K	TCGA-YD-A89C	SKCM	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1944
p.E121K	TCGA-YD-A89C	SKCM	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1111
p.E121K	TCGA-YD-A9TA	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1667
p.E121K	TCGA-YD-A9TA	SKCM	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1944
p.E121K	TCGA-YD-A9TA	SKCM	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1111
p.E121K	DO222837	MELA	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1667
p.E121K	DO222837	MELA	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1944
p.E121K	DO222837	MELA	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1111
p.E121K	DO47380	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1667
p.E121K	DO47380	SKCM	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1944
p.E121K	DO47380	SKCM	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1111
p.E121K	DO219503	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1667
p.E121K	DO219503	SKCM	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1944
p.E121K	DO219503	SKCM	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1111
p.E121K	DO219501	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1667
p.E121K	DO219501	SKCM	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1944
p.E121K	DO219501	SKCM	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1111
p.A152T	TCGA-FI-A2D5	UCEC	TCGA	PPPY	ITCH	145:148	Mutation rewiring degron network	0.2222
p.A152T	DO41331	UCEC	ICGC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.2222
p.P111S	TCGA-FR-A8YC	SKCM	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.2778
p.P111S	DO50301	SKCM	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.2778
p.D119N	TCGA-FS-A1Z0	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1111
p.D119N	TCGA-FS-A1Z0	SKCM	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.25
p.D119N	TCGA-FS-A1Z0	SKCM	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.D119N	TCGA-WE-A8K5	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1111
p.D119N	TCGA-WE-A8K5	SKCM	TCGA	PPPY	ITCH	113:116	Mutation rewiring degron network	0.25
p.D119N	TCGA-WE-A8K5	SKCM	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.D119N	DO37431	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1111
p.D119N	DO37431	SKCM	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.25
p.D119N	DO37431	SKCM	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.D119N	DO51282	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1111
p.D119N	DO51282	SKCM	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.25
p.D119N	DO51282	SKCM	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.D119N	ACH-002310	Liposarcoma	CCLE	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1111
p.D119N	ACH-002310	Liposarcoma	CCLE	PPPY	ITCH	113:116	Mutation rewiring degron network	0.25
p.D119N	ACH-002310	Liposarcoma	CCLE	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.D119N	SW872	soft tissue	COSMIC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1111
p.D119N	SW872	soft tissue	COSMIC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.25
p.D119N	SW872	soft tissue	COSMIC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.P145T	TCGA-L9-A743	LUAD	TCGA	PPPY	ITCH	145:148	Mutation altering degron motif	0.7031
p.P145T	DO49874	LUAD	ICGC	PPPY	ITCH	145:148	Mutation altering degron motif	0.7031
p.P115S	TCGA-QB-AA9O	SKCM	TCGA	PPPY	ITCH	113:116	Mutation altering degron motif	0.5641
p.P115S	DO51267	SKCM	ICGC	PPPY	ITCH	113:116	Mutation altering degron motif	0.5641
p.P145S	TCGA-WE-A8K5	SKCM	TCGA	PPPY	ITCH	145:148	Mutation altering degron motif	0.6752
p.P145S	DO51282	SKCM	ICGC	PPPY	ITCH	145:148	Mutation altering degron motif	0.6752
p.P134T	TCGA-YU-A90Y	TGCT	TCGA	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.5919
p.A140S	DO233114	GACA	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.2222
p.A140S	DO233114	GACA	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1111
p.A140S	DO233114	GACA	ICGC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.1944
p.P106Q	DO229036	LICA	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1389
p.T135S	DO23288	LINC	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation altering degron motif	0.6005
p.P149S	DO220902	MELA	ICGC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.3056
p.P147S	DO222504	MELA	ICGC	PPPY	ITCH	145:148	Mutation altering degron motif	0.5641
p.S143F	DO222702	MELA	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1389
p.S143F	DO222702	MELA	ICGC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.2778
p.R142H	DO49160	PACA	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1667
p.R142H	DO49160	PACA	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.R142H	DO49160	PACA	ICGC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.25
p.R142H	DO51530	PACA	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1667
p.R142H	DO51530	PACA	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.R142H	DO51530	PACA	ICGC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.25
p.P111T	DO232761	PBCA	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.2778
p.Q137H	DO232224	PBCA	ICGC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.3056
p.Q137H	DO232224	PBCA	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1944
p.Q137H	DO232224	PBCA	ICGC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.1111
p.P111L	DO218850	SKCA	ICGC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.2778
p.V107I	SIDM02021	Esophageal Carcinoma	GDSC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1667
p.I120M	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1389
p.I120M	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.2222
p.I120M	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0833
p.I120M	HCC-44	lung	COSMIC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1389
p.I120M	HCC-44	lung	COSMIC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.2222
p.I120M	HCC-44	lung	COSMIC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0833
p.M123I	SIDM01175	Other Sarcomas	GDSC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.2222
p.M123I	SIDM01175	Other Sarcomas	GDSC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1389
p.M123I	SIDM01175	Other Sarcomas	GDSC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1667
p.A153V	SIDM00180	Kidney Carcinoma	GDSC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.1944
p.E122Q	SIDM00151	Ovarian Carcinoma	GDSC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1944
p.E122Q	SIDM00151	Ovarian Carcinoma	GDSC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1667
p.E122Q	SIDM00151	Ovarian Carcinoma	GDSC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1389
p.D120N	SIDM01159	Other Sarcomas	GDSC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1389
p.D120N	SIDM01159	Other Sarcomas	GDSC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.2222
p.D120N	SIDM01159	Other Sarcomas	GDSC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0833
p.E114K	ACH-001568	Skin Cancer	CCLE	PPPY	ITCH	113:116	Mutation altering degron motif	0.7022
p.A152V	ACH-002155	Kidney Cancer	CCLE	PPPY	ITCH	145:148	Mutation rewiring degron network	0.2222
p.A152V	LB996-RCC	kidney	COSMIC	PPPY	ITCH	145:148	Mutation rewiring degron network	0.2222
p.M122I	ACH-002309	Sarcoma	CCLE	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1944
p.M122I	ACH-002309	Sarcoma	CCLE	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1667
p.M122I	ACH-002309	Sarcoma	CCLE	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1389
p.M122I	SW684	soft tissue	COSMIC	DLPPPYSPTP	CBL_PTK	127:136	Mutation rewiring degron network	0.1944
p.M122I	SW684	soft tissue	COSMIC	PPPY	ITCH	113:116	Mutation rewiring degron network	0.1667
p.M122I	SW684	soft tissue	COSMIC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CYYR1

UniProt ID: Q96J86

Entrez ID: 116159

Protein name: Cysteine and tyrosine-rich protein 1 (Proline-rich domain-containing protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CYYR1 in