DegronMD

Degron: DLPPPYSPTP

Uniprot ID: Q96J86

Source protein: Cysteine and tyrosine-rich protein 1

Source gene: CYYR1

Class: CBL_PTK

Location: 127:136

E3 ligase: CBL

DEGRON score: 0.8437

ASA_SCORE: 72.98

COIL: 0.9658

CONS_SCORE: 0.8287

DSS_SCORE: 0.7

HELIX: 0.0151

FCONS_SCORE: 1.1014

RIG_SCORE: 0.5845

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P136S	TCGA-EE-A2GN	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	0.6752
p.P136S	DO37896	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	0.6752
p.P130L	TCGA-06-5416	GBM	TCGA	DLPPPYSPTP	CBL_PTK	0.6471
p.P130L	DO10880	GBM	ICGC	DLPPPYSPTP	CBL_PTK	0.6471
p.T135S	DO23288	LINC	ICGC	DLPPPYSPTP	CBL_PTK	0.6005
p.L128M	TCGA-BS-A0UJ	UCEC	TCGA	DLPPPYSPTP	CBL_PTK	0.5999
p.L128M	DO42745	UCEC	ICGC	DLPPPYSPTP	CBL_PTK	0.5999
p.T135N	TCGA-95-7567	LUAD	TCGA	DLPPPYSPTP	CBL_PTK	0.5944
p.T135N	DO25564	LUAD	ICGC	DLPPPYSPTP	CBL_PTK	0.5944
p.P134T	TCGA-YU-A90Y	TGCT	TCGA	DLPPPYSPTP	CBL_PTK	0.5919
p.P131S	TCGA-19-5956	GBM	TCGA	DLPPPYSPTP	CBL_PTK	0.5641
p.P131S	DO13863	GBM	ICGC	DLPPPYSPTP	CBL_PTK	0.5641
p.Q137H	DO232224	PBCA	ICGC	DLPPPYSPTP	CBL_PTK	0.3056
p.E123K	TCGA-55-6980	LUAD	TCGA	DLPPPYSPTP	CBL_PTK	0.2222
p.E123K	DO25518	LUAD	ICGC	DLPPPYSPTP	CBL_PTK	0.2222
p.A140S	DO233114	GACA	ICGC	DLPPPYSPTP	CBL_PTK	0.2222
p.M123I	SIDM01175	Other Sarcomas	GDSC	DLPPPYSPTP	CBL_PTK	0.2222
p.E122Q	SIDM00151	Ovarian Carcinoma	GDSC	DLPPPYSPTP	CBL_PTK	0.1944
p.M122I	ACH-002309	Sarcoma	CCLE	DLPPPYSPTP	CBL_PTK	0.1944
p.M122I	SW684	soft_tissue	COSMIC	DLPPPYSPTP	CBL_PTK	0.1944
p.E121K	TCGA-ER-A19S	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	0.1667
p.E121K	TCGA-YD-A89C	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	0.1667
p.E121K	TCGA-YD-A9TA	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	0.1667
p.E121K	DO222837	MELA	ICGC	DLPPPYSPTP	CBL_PTK	0.1667
p.E121K	DO47380	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	0.1667

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Drug responses associated with CYYR1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of DLPPPYSPTP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J86	Cysteine and tyrosine-rich protein 1	CBL_PTK	127:136	DLPPPYSPTP	CBL	0.8437	More...

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