DegronMD

Uniprot ID: Q96J86

Source protein: Cysteine and tyrosine-rich protein 1

Source gene: CYYR1

Class: CBL_PTK

Location: 127:136

E3 ligase: CBL

DEGRON score: 0.8437

ASA_SCORE: 72.98

COIL: 0.9658

CONS_SCORE: 0.8287

DSS_SCORE: 0.7

HELIX: 0.0151

FCONS_SCORE: 1.1014

RIG_SCORE: 0.5845

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P130L	TCGA-06-5416	GBM	TCGA	DLPPPYSPTP	CBL_PTK	0.6471
p.P130L	DO10880	GBM	ICGC	DLPPPYSPTP	CBL_PTK	0.6471
p.P131S	TCGA-19-5956	GBM	TCGA	DLPPPYSPTP	CBL_PTK	0.5641
p.P131S	DO13863	GBM	ICGC	DLPPPYSPTP	CBL_PTK	0.5641
p.D119Y	TCGA-2Y-A9GW	LIHC	TCGA	DLPPPYSPTP	CBL_PTK	0.1111
p.D119Y	DO219511	LIHC	ICGC	DLPPPYSPTP	CBL_PTK	0.1111
p.E123K	TCGA-55-6980	LUAD	TCGA	DLPPPYSPTP	CBL_PTK	0.2222
p.E123K	DO25518	LUAD	ICGC	DLPPPYSPTP	CBL_PTK	0.2222
p.T135N	TCGA-95-7567	LUAD	TCGA	DLPPPYSPTP	CBL_PTK	0.5944
p.T135N	DO25564	LUAD	ICGC	DLPPPYSPTP	CBL_PTK	0.5944
p.D119V	TCGA-AJ-A3EK	UCEC	TCGA	DLPPPYSPTP	CBL_PTK	0.1111
p.D119V	DO41584	UCEC	ICGC	DLPPPYSPTP	CBL_PTK	0.1111
p.L128M	TCGA-BS-A0UJ	UCEC	TCGA	DLPPPYSPTP	CBL_PTK	0.5999
p.L128M	DO42745	UCEC	ICGC	DLPPPYSPTP	CBL_PTK	0.5999
p.P136S	TCGA-EE-A2GN	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	0.6752
p.P136S	DO37896	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	0.6752
p.E121K	TCGA-ER-A19S	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	0.1667
p.E121K	TCGA-YD-A89C	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	0.1667
p.E121K	TCGA-YD-A9TA	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	0.1667
p.E121K	DO222837	MELA	ICGC	DLPPPYSPTP	CBL_PTK	0.1667
p.E121K	DO47380	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	0.1667
p.E121K	DO219503	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	0.1667
p.E121K	DO219501	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	0.1667
p.D119N	TCGA-FS-A1Z0	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	0.1111
p.D119N	TCGA-WE-A8K5	SKCM	TCGA	DLPPPYSPTP	CBL_PTK	0.1111
p.D119N	DO37431	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	0.1111
p.D119N	DO51282	SKCM	ICGC	DLPPPYSPTP	CBL_PTK	0.1111
p.D119N	ACH-002310	Liposarcoma	CCLE	DLPPPYSPTP	CBL_PTK	0.1111
p.D119N	SW872	soft_tissue	COSMIC	DLPPPYSPTP	CBL_PTK	0.1111
p.P134T	TCGA-YU-A90Y	TGCT	TCGA	DLPPPYSPTP	CBL_PTK	0.5919
p.A140S	DO233114	GACA	ICGC	DLPPPYSPTP	CBL_PTK	0.2222
p.T135S	DO23288	LINC	ICGC	DLPPPYSPTP	CBL_PTK	0.6005
p.S143F	DO222702	MELA	ICGC	DLPPPYSPTP	CBL_PTK	0.1389
p.R142H	DO49160	PACA	ICGC	DLPPPYSPTP	CBL_PTK	0.1667
p.R142H	DO51530	PACA	ICGC	DLPPPYSPTP	CBL_PTK	0.1667
p.Q137H	DO232224	PBCA	ICGC	DLPPPYSPTP	CBL_PTK	0.3056
p.I120M	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	DLPPPYSPTP	CBL_PTK	0.1389
p.I120M	HCC-44	lung	COSMIC	DLPPPYSPTP	CBL_PTK	0.1389
p.M123I	SIDM01175	Other Sarcomas	GDSC	DLPPPYSPTP	CBL_PTK	0.2222
p.E122Q	SIDM00151	Ovarian Carcinoma	GDSC	DLPPPYSPTP	CBL_PTK	0.1944
p.D120N	SIDM01159	Other Sarcomas	GDSC	DLPPPYSPTP	CBL_PTK	0.1389
p.M122I	ACH-002309	Sarcoma	CCLE	DLPPPYSPTP	CBL_PTK	0.1944
p.M122I	SW684	soft_tissue	COSMIC	DLPPPYSPTP	CBL_PTK	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DLPPPYSPTP

Degron related mutations and impact score

Drug responses associated with CYYR1 mutations

All proteins holding degron of DLPPPYSPTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J86	Cysteine and tyrosine-rich protein 1	CBL_PTK	127:136	DLPPPYSPTP	CBL	0.8437	More...