DegronMD - Q86U86(PBRM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G22W	TCGA-05-4396	LUAD	TCGA	VSTPGPS	DEG_SCF_FBW7_1	26:32	Mutation rewiring degron network	0.2222
p.G22W	DO23838	LUAD	ICGC	VSTPGPS	DEG_SCF_FBW7_1	26:32	Mutation rewiring degron network	0.2222
p.R1359C	TCGA-27-2527	GBM	TCGA	MPYTPPQS	DEG_SCF_FBW7_1	1356:1363	Mutation altering degron motif	0.8301
p.G17V	TCGA-55-6979	LUAD	TCGA	VSTPGPS	DEG_SCF_FBW7_1	26:32	Mutation rewiring degron network	0.0833
p.G17V	DO24110	LUAD	ICGC	VSTPGPS	DEG_SCF_FBW7_1	26:32	Mutation rewiring degron network	0.0833
p.D20G	TCGA-AP-A054	UCEC	TCGA	VSTPGPS	DEG_SCF_FBW7_1	26:32	Mutation rewiring degron network	0.1667
p.D20G	DO42256	UCEC	ICGC	VSTPGPS	DEG_SCF_FBW7_1	26:32	Mutation rewiring degron network	0.1667
p.P42L	TCGA-B4-5832	KIRC	TCGA	KRRRLSNLP	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.6471
p.P42L	DO17236	KIRC	ICGC	KRRRLSNLP	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.6471
p.P42L	DO232148	RECA	ICGC	KRRRLSNLP	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.6471
p.R1563P	TCGA-CJ-4923	KIRC	TCGA	PPPY	ITCH	1572:1575	Mutation rewiring degron network	0.0833
p.L1565M	TCGA-EE-A3AG	SKCM	TCGA	PPPY	ITCH	1572:1575	Mutation rewiring degron network	0.1389
p.R1574H	TCGA-EO-A22X	UCEC	TCGA	PPPY	ITCH	1572:1575	Mutation altering degron motif	0.8244
p.A1347D	TCGA-FI-A2F8	UCEC	TCGA	MPYTPPQS	DEG_SCF_FBW7_1	1356:1363	Mutation rewiring degron network	0.0833
p.G17R	TCGA-XK-AAIW	PRAD	TCGA	VSTPGPS	DEG_SCF_FBW7_1	26:32	Mutation rewiring degron network	0.0833
p.G17R	DO51407	PRAD	ICGC	VSTPGPS	DEG_SCF_FBW7_1	26:32	Mutation rewiring degron network	0.0833
p.K1373N	DO219015	BLCA	ICGC	MPYTPPQS	DEG_SCF_FBW7_1	1356:1363	Mutation substituting flanking lysine	0.1667
p.S32R	DO8898	COAD	ICGC	VSTPGPS	DEG_SCF_FBW7_1	26:32	Mutation altering degron motif	0.8538
p.K1366T	DO233910	GACA	ICGC	MPYTPPQS	DEG_SCF_FBW7_1	1356:1363	Mutation substituting flanking lysine	0.3611
p.T1347N	DO229009	LICA	ICGC	MPYTPPQS	DEG_SCF_FBW7_1	1356:1363	Mutation rewiring degron network	0.0833
p.D1582N	DO26898	LUSC	ICGC	PPPY	ITCH	1572:1575	Mutation rewiring degron network	0.1389
p.S1367F	DO42977	UCEC	ICGC	MPYTPPQS	DEG_SCF_FBW7_1	1356:1363	Mutation blocking phosphorylation signal	0.6667
p.S1367F	SIDM00458	Acute Myeloid Leukemia	GDSC	MPYTPPQS	DEG_SCF_FBW7_1	1356:1363	Mutation blocking phosphorylation signal	0.6667
p.S1367F	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	MPYTPPQS	DEG_SCF_FBW7_1	1356:1363	Mutation blocking phosphorylation signal	0.6667
p.R1581C	DO41199	UCEC	ICGC	PPPY	ITCH	1572:1575	Mutation rewiring degron network	0.1667
p.P46S	SIDM01943	Colorectal Carcinoma	GDSC	KRRRLSNLP	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.2222
p.V49L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	KRRRLSNLP	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1389
p.V49L	ACH-000945	Lung Cancer	CCLE	KRRRLSNLP	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1389
p.V49L	NCI-H650	lung	COSMIC	KRRRLSNLP	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1389
p.D45H	SIDM00892	Breast Carcinoma	GDSC	KRRRLSNLP	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.25
p.D45H	ACH-000818	Breast Cancer	CCLE	KRRRLSNLP	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.25
p.D45H	BT-483	breast	COSMIC	KRRRLSNLP	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.25
p.E1350G	ACH-000158	Lymphoma	CCLE	MPYTPPQS	DEG_SCF_FBW7_1	1356:1363	Mutation rewiring degron network	0.1667
p.T43I	ACH-001369	Ovarian Cancer	CCLE	KRRRLSNLP	DEG_APCC_DBOX_1	34:42	Mutation blocking phosphorylation signal	0.75
p.K1372N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	MPYTPPQS	DEG_SCF_FBW7_1	1356:1363	Mutation rewiring degron network	0.0833

Kaplan plot for PBRM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PBRM1

UniProt ID: Q86U86

Entrez ID: 55193

Protein name: Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PBRM1 in