DegronMD

Uniprot ID: Q86U86

Source protein: Protein polybromo-1

Source gene: PBRM1

Class: DEG_APCC_DBOX_1

Location: 34:42

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9926

ASA_SCORE: 116.4111

COIL: 0.9262

CONS_SCORE: 0.3329

DSS_SCORE: 0.5321

HELIX: 0.0472

FCONS_SCORE: 1.0614

RIG_SCORE: 0.6822

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P42L	TCGA-B4-5832	KIRC	TCGA	KRRRLSNLP	DEG_APCC_DBOX_1	0.6471
p.P42L	DO17236	KIRC	ICGC	KRRRLSNLP	DEG_APCC_DBOX_1	0.6471
p.P42L	DO232148	RECA	ICGC	KRRRLSNLP	DEG_APCC_DBOX_1	0.6471
p.P46S	SIDM01943	Colorectal Carcinoma	GDSC	KRRRLSNLP	DEG_APCC_DBOX_1	0.2222
p.V49L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	KRRRLSNLP	DEG_APCC_DBOX_1	0.1389
p.V49L	ACH-000945	Lung Cancer	CCLE	KRRRLSNLP	DEG_APCC_DBOX_1	0.1389
p.V49L	NCI-H650	lung	COSMIC	KRRRLSNLP	DEG_APCC_DBOX_1	0.1389
p.D45H	SIDM00892	Breast Carcinoma	GDSC	KRRRLSNLP	DEG_APCC_DBOX_1	0.25
p.D45H	ACH-000818	Breast Cancer	CCLE	KRRRLSNLP	DEG_APCC_DBOX_1	0.25
p.D45H	BT-483	breast	COSMIC	KRRRLSNLP	DEG_APCC_DBOX_1	0.25
p.T43I	ACH-001369	Ovarian Cancer	CCLE	KRRRLSNLP	DEG_APCC_DBOX_1	0.75

Drug responses associated with PBRM1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00988	KIRC\|kidney	p.G1145S (No)	GDSC	PFI-3	71.6761
SIDM00572	STAD\|stomach	p.G1199* (No)	GDSC	PFI-3	111.6851
SIDM01045	UCEC\|endometrium	p.K959fs*23 (No)	GDSC	PFI-3	219.324
SIDM00214	COREAD\|large_intestine	p.N923fs*59 (No)	GDSC	PFI-3	124.0354
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V1132fs*17 (No)	GDSC	PFI-3	108.2125
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.K183* (No)	GDSC	PFI-3	278.7279
SIDM00220	OV\|ovary	p.R298* (No)	GDSC	PFI-3	87.0198
SIDM00139	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Q1472* (No)	GDSC	PFI-3	120.8778
SIDM00455	PAAD\|pancreas	p.L1477fs*32 (No)	GDSC	PFI-3	143.9494
SIDM00849	KIRC\|kidney	p.E540fs*16 (No)	GDSC	PFI-3	103.4626
SIDM00220	OV\|ovary	p.P1431fs*21 (No)	GDSC	PFI-3	87.0198
SIDM00819	KIRC\|kidney	p.Q445* (No)	GDSC	PFI-3	155.3515
SIDM00820	KIRC\|kidney	p.D251fs*31 (No)	GDSC	PFI-3	133.7233
SIDM01146	STAD\|stomach	p.I279fs*4 (No)	GDSC	PFI-3	136.7007
SIDM00723	UNCLASSIFIED\|lung_NSCLC_not_specified	p.S1246fs*7 (No)	GDSC	PFI-3	188.7769
SIDM00611	KIRC\|kidney	p.W1151* (No)	GDSC	PFI-3	144.4576
SIDM00333	UCEC\|endometrium	p.K284fs*16 (No)	GDSC	PFI-3	103.0972
SIDM00118	COREAD\|large_intestine	p.R678* (No)	GDSC	PFI-3	112.9535
SIDM01194	LIHC\|liver	p.Y861C (No)	GDSC	PFI-3	130.3594
SIDM00841	COREAD\|large_intestine	p.R950K (No)	GDSC	PFI-3	287.8979
SIDM00951	LAML\|acute_myeloid_leukaemia	p.E226G (No)	GDSC	PFI-3	50.9052
SIDM01086	ALL\|leukemia	p.R1088Q (No)	GDSC	PFI-3	42.4835
SIDM01135	PAAD\|pancreas	p.R502* (No)	GDSC	PFI-3	158.1729
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.T172I (No)	GDSC	PFI-3	50.2525
SIDM00348	ESCA\|oesophagus	p.Y527D (No)	GDSC	PFI-3	92.9116
SIDM00121	ALL\|lymphoblastic_leukemia	p.E206K (No)	GDSC	PFI-3	57.0805
SIDM00683	PRAD\|prostate	p.Y1011F (No)	GDSC	PFI-3	149.7318
SIDM00997	THCA\|thyroid	p.G1465A (No)	GDSC	PFI-3	150.6385
SIDM01007	ALL\|lymphoblastic_leukemia	p.K1392N (No)	GDSC	PFI-3	71.009
SIDM00146	BRCA\|breast	p.I228V (No)	GDSC	PFI-3	136.937
SIDM00091	OV\|ovary	p.A256T (No)	GDSC	PFI-3	74.5529
SIDM00176	UNCLASSIFIED\|chondrosarcoma	p.Y861C (No)	GDSC	PFI-3	102.8319
SIDM01090	COREAD\|large_intestine	p.P1047H (No)	GDSC	PFI-3	88.1141
SIDM01090	COREAD\|large_intestine	p.P1047S (No)	GDSC	PFI-3	88.1141
SIDM00998	GBM\|glioma	p.T56A (No)	GDSC	PFI-3	54.4234
SIDM00239	KIRC\|kidney	p.I233T (No)	GDSC	PFI-3	126.6179
SIDM00194	COREAD\|large_intestine	p.R309H (No)	GDSC	PFI-3	325.7004
SIDM00751	LUAD\|lung_NSCLC_adenocarcinoma	p.D1082N (No)	GDSC	PFI-3	226.6058
SIDM00187	KIRC\|kidney	p.R1213G (No)	GDSC	PFI-3	74.3949
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T863S (No)	GDSC	PFI-3	40.5518
SIDM00946	ALL\|T_cell_leukemia	p.A683T (No)	GDSC	PFI-3	68.7687
SIDM00794	UNCLASSIFIED\|skin_other	p.R646C (No)	GDSC	PFI-3	48.1231
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.S988T (No)	GDSC	PFI-3	40.5717
SIDM00630	BRCA\|breast	p.E1255Q (No)	GDSC	PFI-3	166.8193
SIDM00405	DLBC\|B_cell_lymphoma	p.N1122S (No)	GDSC	PFI-3	26.8504
SIDM00812	COREAD\|large_intestine	p.R66G (No)	GDSC	PFI-3	199.3717
SIDM00140	SKCM\|melanoma	p.R1228H (No)	GDSC	PFI-3	164.7422
SIDM00323	DLBC\|B_cell_lymphoma	p.A683T (No)	GDSC	PFI-3	79.5651
SIDM00231	KIRC\|kidney	p.K1237* (No)	GDSC	PFI-3	127.9852
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.M299I (No)	GDSC	PFI-3	99.6739
SIDM00596	UCEC\|endometrium	p.Q1473H (No)	GDSC	PFI-3	95.2821
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.Y967C (No)	GDSC	PFI-3	80.4494
SIDM00458	LAML\|acute_myeloid_leukaemia	p.S1335F (No)	GDSC	PFI-3	32.496
SIDM00589	HNSC\|head_and_neck	p.D1073H (No)	GDSC	PFI-3	33.8824
SIDM00609	KIRC\|kidney	p.N421Y (No)	GDSC	PFI-3	136.0313
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y640C (No)	GDSC	PFI-3	66.1328
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.L1317fs*35 (No)	GDSC	PFI-3	65.6013
SIDM00502	DLBC\|B_cell_lymphoma	p.E160A (No)	GDSC	PFI-3	97.3333
SIDM00502	DLBC\|B_cell_lymphoma	p.Y144F (No)	GDSC	PFI-3	97.3333
SIDM00816	KIRC\|kidney	p.N496fs*41 (No)	GDSC	PFI-3	167.9464
SIDM00549	ALL\|lymphoblastic_leukemia	p.Y861C (No)	GDSC	PFI-3	93.0426
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I401V (No)	GDSC	PFI-3	87.363
SIDM00373	UCEC\|endometrium	p.R202C (No)	GDSC	PFI-3	71.0053
SIDM00983	BLCA\|bladder	p.Q90E (No)	GDSC	PFI-3	122.5274
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.V49L (Yes)	GDSC	PFI-3	204.3988
SIDM00892	BRCA\|breast	p.D45H (Yes)	GDSC	PFI-3	177.572
SIDM00365	SCLC\|lung_small_cell_carcinoma	p.Y861C (No)	GDSC	PFI-3	74.7239
SIDM01146	STAD\|stomach	p.G1416C (No)	GDSC	PFI-3	136.7007
SIDM00237	LUAD\|lung_NSCLC_adenocarcinoma	p.A1202T (No)	GDSC	PFI-3	235.7953
SIDM00123	KIRC\|kidney	p.R1020* (No)	GDSC	PFI-3	127.6919
SIDM00193	COREAD\|large_intestine	p.N1187Y (No)	GDSC	PFI-3	219.9618
SIDM00118	COREAD\|large_intestine	p.K893Q (No)	GDSC	PFI-3	112.9535

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRRRLSNLP

Degron related mutations and impact score

Drug responses associated with PBRM1 mutations

All proteins holding degron of KRRRLSNLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86U86	Protein polybromo-1	DEG_APCC_DBOX_1	34:42	KRRRLSNLP	APC,CDC20,FZR1	0.9926	More...