DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPPY
Uniprot ID:
Q9NV92
Source protein:
NEDD4 family-interacting protein 2
Source gene:
NDFIP2
Class:
ITCH
Location:
148:151
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9623
ASA_SCORE:
82.775
COIL:
0.905
CONS_SCORE:
0.5947
DSS_SCORE:
0.5806
HELIX:
0.0315
FCONS_SCORE:
1.4013
RIG_SCORE:
0.5839
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P149S
TCGA-D3-A5GU
SKCM
TCGA
PPPY
ITCH
0.6752
p.P149S
DO47584
SKCM
ICGC
PPPY
ITCH
0.6752
p.S152N
SIDM01175
Other Sarcomas
GDSC
PPPY
ITCH
0.3056
p.S152N
SIDM00942
Oral Cavity Carcinoma
GDSC
PPPY
ITCH
0.3056
p.S152N
SIDM00102
Mesothelioma
GDSC
PPPY
ITCH
0.3056
p.S152N
SIDM01693
B-Lymphoblastic Leukemia
GDSC
PPPY
ITCH
0.3056
p.S153R
TCGA-13-1501
OV
TCGA
PPPY
ITCH
0.2778
p.S153R
DO28168
OV
ICGC
PPPY
ITCH
0.2778
p.C155Y
NCI-H1155
lung
COSMIC
PPPY
ITCH
0.2222
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Drug responses associated with NDFIP2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPPY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96DV4
39S ribosomal protein L38, mitochondrial
ITCH
347:350
PPPY
ITCH,NEDD4
0.6466
More...
O15072
A disintegrin and metalloproteinase with thrombospondin motifs 3
ITCH
1058:1061
PPPY
ITCH,NEDD4
0.9797
More...
Q13625
Apoptosis-stimulating of p53 protein 2
ITCH
871:874
PPPY
ITCH,NEDD4
0.9885
More...
P54259
Atrophin-1
ITCH
445:448
PPPY
ITCH,NEDD4
0.973
More...
P54259
Atrophin-1
ITCH
636:639
PPPY
ITCH,NEDD4
0.9909
More...
Q8WXX7
Autism susceptibility gene 2 protein
ITCH
516:519
PPPY
ITCH,NEDD4
0.9979
More...
O00512
B-cell CLL/lymphoma 9 protein
ITCH
515:518
PPPY
ITCH,NEDD4
0.9973
More...
Q86UU0
B-cell CLL/lymphoma 9-like protein
ITCH
561:564
PPPY
ITCH,NEDD4
0.9923
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O95395
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
ITCH
285:288
PPPY
ITCH,NEDD4
0.5532
More...
O95415
Brain protein I3
ITCH
39:42
PPPY
ITCH,NEDD4
0.9496
More...
Q15018
BRISC complex subunit Abraxas 2
ITCH
305:308
PPPY
ITCH,NEDD4
0.9939
More...
Q9P203
BTB/POZ domain-containing protein 7
ITCH
762:765
PPPY
ITCH,NEDD4
0.9575
More...
Q9Y6W3
Calpain-7
ITCH
624:627
PPPY
ITCH,NEDD4
0.5393
More...
Q8WXE0
Caskin-2
ITCH
751:754
PPPY
ITCH,NEDD4
0.6879
More...
Q9H305
Cell death-inducing p53-target protein 1
ITCH
6:9
PPPY
ITCH,NEDD4
0.9945
More...
Q9H305
Cell death-inducing p53-target protein 1
ITCH
51:54
PPPY
ITCH,NEDD4
0.9943
More...
Q16630
Cleavage and polyadenylation specificity factor subunit 6
ITCH
387:390
PPPY
ITCH,NEDD4
0.9919
More...
Q8WXI2
Connector enhancer of kinase suppressor of ras 2
ITCH
704:707
PPPY
ITCH,NEDD4
0.9478
More...
Q86YQ8
Copine-8
ITCH
550:553
PPPY
ITCH,NEDD4
0.743
More...
Q6UUV7
CREB-regulated transcription coactivator 3
ITCH
445:448
PPPY
ITCH,NEDD4
0.998
More...
Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
113:116
PPPY
ITCH,NEDD4
0.9396
More...
Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
129:132
PPPY
ITCH,NEDD4
0.9428
More...
Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
145:148
PPPY
ITCH,NEDD4
0.9794
More...
Q9H1C7
Cysteine-rich and transmembrane domain-containing protein 1
ITCH
6:9
PPPY
ITCH,NEDD4
0.9391
More...
Q9BTC0
Death-inducer obliterator 1
ITCH
1817:1820
PPPY
ITCH,NEDD4
0.9967
More...
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