DegronMD - Q9H3D4(TP63)

GO - Biological processes (BP): apoptotic process [GO:0006915]; cell aging [GO:0007569]; cell population proliferation [GO:0008283]; cellular response to DNA damage stimulus [GO:0006974]; chromatin remodeling [GO:0006338]; cloacal septation [GO:0060197]; cranial skeletal system development [GO:1904888]; ectoderm and mesoderm interaction [GO:0007499]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; epidermal cell division [GO:0010481]; epithelial cell development [GO:0002064]; establishment of planar polarity [GO:0001736]; establishment of skin barrier [GO:0061436]; female genitalia morphogenesis [GO:0048807]; hair follicle morphogenesis [GO:0031069]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; keratinocyte differentiation [GO:0030216]; multicellular organism aging [GO:0010259]; negative regulation of cellular senescence [GO:2000773]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mesoderm development [GO:2000381]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of somatic stem cell population maintenance [GO:1904674]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; prostatic bud formation [GO:0060513]; protein tetramerization [GO:0051262]; proximal/distal pattern formation [GO:0009954]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of epidermal cell division [GO:0010482]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; spermatogenesis [GO:0007283]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; sympathetic nervous system development [GO:0048485] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P65H	TCGA-2W-A8YY	CESC	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.25
p.P65H	DO223732	CESC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.25
p.D546N	TCGA-3N-A9WC	SKCM	TCGA	PPPY	ITCH	540:543	Mutation rewiring degron network	0.25
p.S68L	TCGA-81-5910	GBM	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1667
p.S68L	DO11435	GBM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1667
p.S68L	ACH-000987	Skin Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1667
p.S68L	Mewo	skin	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1667
p.E53Q	TCGA-95-7039	LUAD	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.2778
p.E53Q	DO23907	LUAD	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.2778
p.P539S	TCGA-A5-A1OF	UCEC	TCGA	PPPY	ITCH	540:543	Mutation rewiring degron network	0.3056
p.Y543F	TCGA-AP-A1E1	UCEC	TCGA	PPPY	ITCH	540:543	Mutation altering degron motif	0.7528
p.L553I	TCGA-BR-8363	STAD	TCGA	PPPY	ITCH	540:543	Mutation rewiring degron network	0.0556
p.S535F	TCGA-EE-A181	SKCM	TCGA	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1944
p.S535F	TCGA-GN-A8LK	SKCM	TCGA	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1944
p.D60N	TCGA-EE-A29E	SKCM	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.5821
p.D60N	TCGA-EE-A2MK	SKCM	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.5821
p.D60N	TCGA-W3-AA1V	SKCM	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.5821
p.D60N	DO222615	MELA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.5821
p.D60N	DO37831	SKCM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.5821
p.D60N	DO51276	SKCM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.5821
p.D60N	DO38177	SKCM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.5821
p.F552L	TCGA-F5-6814	READ	TCGA	PPPY	ITCH	540:543	Mutation rewiring degron network	0.0833
p.F552L	ACH-001234	Lung Cancer	CCLE	PPPY	ITCH	540:543	Mutation rewiring degron network	0.0833
p.S533F	TCGA-FR-A3YN	SKCM	TCGA	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1389
p.I58T	TCGA-GV-A3JV	BLCA	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.5966
p.I58T	DO743	BLCA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.5966
p.P532S	TCGA-W3-AA1V	SKCM	TCGA	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1111
p.P532L	TCGA-YD-A9TA	SKCM	TCGA	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1111
p.P65S	DO1191	BRCA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.25
p.S532C	DO1269	BRCA	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1111
p.E534K	DO15791	HNSC	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1667
p.G537V	DO14186	HNSC	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.25
p.A70T	DO220490	KICH	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1111
p.A70T	DO42568	UCEC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1111
p.A56S	DO229035	LICA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.7588
p.A45V	DO49694	LIHC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.0556
p.A45V	DO40801	UCEC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.0556
p.G531C	DO23645	LUAD	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.0833
p.R549C	DO219182	LUSC	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1667
p.R549C	SK-MEL-3	skin	COSMIC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1667
p.R545Q	DO222420	MELA	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.2778
p.R545Q	DO222426	MELA	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.2778
p.R545Q	DO28071	OV	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.2778
p.R545Q	DO37559	SKCM	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.2778
p.R545Q	DO37404	SKCM	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.2778
p.R545Q	DO219456	SKCM	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.2778
p.S532F	DO37535	SKCM	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1111
p.L548V	DO37412	SKCM	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1944
p.P72H	DO38141	SKCM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.0556
p.A45T	DO38683	STAD	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.0556
p.A45T	DO222337	STAD	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.0556
p.A45T	ACH-000570	Brain Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.0556
p.A45T	YKG-1	central nervous system	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.0556
p.S532Y	DO42568	UCEC	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1111
p.T50M	DO41199	UCEC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1944
p.A56T	DO42793	UCEC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.7139
p.R539C	DO42673	UCEC	ICGC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.3056
p.P539L	SIDM00149	Melanoma	GDSC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.3056
p.P539L	LOXIMVI	skin	COSMIC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.3056
p.Q70H	SIDM01018	Hodgkin's Lymphoma	GDSC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1111
p.Q70H	ACH-000815	Lymphoma	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1111
p.Q70H	ACH-002038	Ovarian Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1111
p.Q70H	ACH-002055	Lymphoma	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1111
p.Q70H	KM-H2	haematopoietic and lymphoid tissue	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1111
p.E542Q	ACH-000004	Leukemia	CCLE	PPPY	ITCH	540:543	Mutation altering degron motif	0.6744
p.E542Q	ACH-000005	Leukemia	CCLE	PPPY	ITCH	540:543	Mutation altering degron motif	0.6744
p.E542Q	HEL	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	540:543	Mutation altering degron motif	0.6744
p.E542Q	CMK	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	540:543	Mutation altering degron motif	0.6744
p.R553C	ACH-000423	Skin Cancer	CCLE	PPPY	ITCH	540:543	Mutation rewiring degron network	0.0556
p.R553C	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	540:543	Mutation rewiring degron network	0.0556
p.R553C	SK-MEL-3	skin	COSMIC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.0556
p.T61I	ACH-000472	Head and Neck Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.7078
p.T61I	HSC-2	upper aerodigestive tract	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.7078
p.P54L	ACH-000805	Skin Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.3056
p.S60C	ACH-000839	Bladder Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.7541
p.S60C	SCaBER	urinary tract	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.7541
p.S60F	ACH-002180	Cervical Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.7982
p.S60F	OMC-1	cervix	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation altering degron motif	0.7982
p.V544I	ACH-002347	Non-Cancerous	CCLE	PPPY	ITCH	540:543	Mutation rewiring degron network	0.3056
p.T547P	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.2222
p.E538Q	CMK	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.2778
p.E538Q	HEL	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.2778
p.T551P	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1111
p.R64W	SNU-175	large intestine	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.2778
p.R64W	IM-95	stomach	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.2778
p.E69A	AN3-CA	endometrium	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	55:62	Mutation rewiring degron network	0.1389
p.P535L	LOXIMVI	skin	COSMIC	PPPY	ITCH	540:543	Mutation rewiring degron network	0.1944

Kaplan plot for TP63 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TP63

UniProt ID: Q9H3D4

Entrez ID: 8626

Protein name: Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TP63 in