DegronMD

Uniprot ID: Q9H3D4

Source protein: Tumor protein 63

Source gene: TP63

Class: DEG_MDM2_SWIB_1

Location: 55:62

E3 ligase: MDM2

DEGRON score: 0.857

ASA_SCORE: 48.0125

COIL: 0.1156

CONS_SCORE: 0.2429

DSS_SCORE: 0.1826

HELIX: 0.8753

FCONS_SCORE: 0.9308

RIG_SCORE: 0.9152

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S60F	ACH-002180	Cervical Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.7982
p.S60F	OMC-1	cervix	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.7982
p.A56S	DO229035	LICA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.7588
p.S60C	ACH-000839	Bladder Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.7541
p.S60C	SCaBER	urinary_tract	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.7541
p.A56T	DO42793	UCEC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.7139
p.T61I	ACH-000472	Head and Neck Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.7078
p.T61I	HSC-2	upper_aerodigestive_tract	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.7078
p.I58T	TCGA-GV-A3JV	BLCA	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.5966
p.I58T	DO743	BLCA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.5966
p.D60N	TCGA-EE-A29E	SKCM	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	TCGA-EE-A2MK	SKCM	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	TCGA-W3-AA1V	SKCM	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	DO222615	MELA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	DO37831	SKCM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	DO51276	SKCM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	DO38177	SKCM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.P54L	ACH-000805	Skin Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.3056
p.E53Q	TCGA-95-7039	LUAD	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.2778
p.E53Q	DO23907	LUAD	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.2778
p.R64W	SNU-175	large_intestine	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.2778
p.R64W	IM-95	stomach	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.2778
p.P65H	TCGA-2W-A8YY	CESC	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.25
p.P65H	DO223732	CESC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.25
p.P65S	DO1191	BRCA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.25

Showing 1 to 25 of 45 entries

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3D4	Tumor protein 63	DEG_MDM2_SWIB_1	55:62	FQHIWDFL	MDM2	0.857	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons