DegronMD

Uniprot ID: Q9H3D4

Source protein: Tumor protein 63

Source gene: TP63

Class: DEG_MDM2_SWIB_1

Location: 55:62

E3 ligase: MDM2

DEGRON score: 0.857

ASA_SCORE: 48.0125

COIL: 0.1156

CONS_SCORE: 0.2429

DSS_SCORE: 0.1826

HELIX: 0.8753

FCONS_SCORE: 0.9308

RIG_SCORE: 0.9152

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P65H	TCGA-2W-A8YY	CESC	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.25
p.P65H	DO223732	CESC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.25
p.S68L	TCGA-81-5910	GBM	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.1667
p.S68L	DO11435	GBM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.1667
p.S68L	ACH-000987	Skin Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.1667
p.S68L	Mewo	skin	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.1667
p.E53Q	TCGA-95-7039	LUAD	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.2778
p.E53Q	DO23907	LUAD	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.2778
p.D60N	TCGA-EE-A29E	SKCM	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	TCGA-EE-A2MK	SKCM	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	TCGA-W3-AA1V	SKCM	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	DO222615	MELA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	DO37831	SKCM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	DO51276	SKCM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.D60N	DO38177	SKCM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.5821
p.I58T	TCGA-GV-A3JV	BLCA	TCGA	FQHIWDFL	DEG_MDM2_SWIB_1	0.5966
p.I58T	DO743	BLCA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.5966
p.P65S	DO1191	BRCA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.25
p.A70T	DO220490	KICH	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.1111
p.A70T	DO42568	UCEC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.1111
p.A56S	DO229035	LICA	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.7588
p.A45V	DO49694	LIHC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.0556
p.A45V	DO40801	UCEC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.0556
p.P72H	DO38141	SKCM	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.0556
p.A45T	DO38683	STAD	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.0556
p.A45T	DO222337	STAD	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.0556
p.A45T	ACH-000570	Brain Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.0556
p.A45T	YKG-1	central_nervous_system	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.0556
p.T50M	DO41199	UCEC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.1944
p.A56T	DO42793	UCEC	ICGC	FQHIWDFL	DEG_MDM2_SWIB_1	0.7139
p.Q70H	SIDM01018	Hodgkin's Lymphoma	GDSC	FQHIWDFL	DEG_MDM2_SWIB_1	0.1111
p.Q70H	ACH-000815	Lymphoma	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.1111
p.Q70H	ACH-002038	Ovarian Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.1111
p.Q70H	ACH-002055	Lymphoma	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.1111
p.Q70H	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.1111
p.T61I	ACH-000472	Head and Neck Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.7078
p.T61I	HSC-2	upper_aerodigestive_tract	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.7078
p.P54L	ACH-000805	Skin Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.3056
p.S60C	ACH-000839	Bladder Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.7541
p.S60C	SCaBER	urinary_tract	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.7541
p.S60F	ACH-002180	Cervical Cancer	CCLE	FQHIWDFL	DEG_MDM2_SWIB_1	0.7982
p.S60F	OMC-1	cervix	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.7982
p.R64W	SNU-175	large_intestine	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.2778
p.R64W	IM-95	stomach	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.2778
p.E69A	AN3-CA	endometrium	COSMIC	FQHIWDFL	DEG_MDM2_SWIB_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FQHIWDFL

Degron related mutations and impact score

Drug responses associated with TP63 mutations

All proteins holding degron of FQHIWDFL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3D4	Tumor protein 63	DEG_MDM2_SWIB_1	55:62	FQHIWDFL	MDM2	0.857	More...