DegronMD - Q8IW70(TMEM151B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A533T	DO44096	COAD	ICGC	PPPY	ITCH	527:530	Mutation rewiring degron network	0.25
p.A533T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	527:530	Mutation rewiring degron network	0.25
p.A450T	DO50453	ESAD	ICGC	AVSSS	DEG_SPOP_SBC_1	439:443	Mutation rewiring degron network	0.1389
p.P463L	DO50390	ESAD	ICGC	SRFSLGRLY	DEG_APCC_DBOX_1	472:480	Mutation rewiring degron network	0.0833
p.P537L	DO234462	ESAD	ICGC	PPPY	ITCH	527:530	Mutation rewiring degron network	0.1389
p.D520E	DO14192	HNSC	ICGC	PPPY	ITCH	527:530	Mutation rewiring degron network	0.1389
p.G481S	DO218306	ORCA	ICGC	SRFSLGRLY	DEG_APCC_DBOX_1	472:480	Mutation rewiring degron network	0.3056
p.E522G	DO229227	THCA	ICGC	PPPY	ITCH	527:530	Mutation rewiring degron network	0.1944
p.R478C	ACH-000971	Colon/Colorectal Cancer	CCLE	SRFSLGRLY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.719

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons