DegronMD

Uniprot ID: Q8IW70

Source protein: Transmembrane protein 151B

Source gene: TMEM151B

Class: DEG_APCC_DBOX_1

Location: 472:480

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9271

ASA_SCORE: 79.4889

COIL: 0.7726

CONS_SCORE: 0.4515

DSS_SCORE: 0.2724

HELIX: 0.0894

FCONS_SCORE: 1.2374

RIG_SCORE: 0.757

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P463L	DO50390	ESAD	ICGC	SRFSLGRLY	DEG_APCC_DBOX_1	0.0833
p.G481S	DO218306	ORCA	ICGC	SRFSLGRLY	DEG_APCC_DBOX_1	0.3056
p.R478C	ACH-000971	Colon/Colorectal Cancer	CCLE	SRFSLGRLY	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IW70	Transmembrane protein 151B	DEG_APCC_DBOX_1	472:480	SRFSLGRLY	APC,CDC20,FZR1	0.9271	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons