DegronMD - Q14151(SAFB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S207Y	TCGA-49-4487	LUAD	TCGA	VTPDIE	DEG_SCF_FBW7_2	200:205	Mutation blocking phosphorylation signal	0.7222
p.S207Y	DO24780	LUAD	ICGC	VTPDIE	DEG_SCF_FBW7_2	200:205	Mutation blocking phosphorylation signal	0.7222
p.H948Q	TCGA-5P-A9K2	KIRP	TCGA	PPPY	ITCH	943:946	Mutation rewiring degron network	0.2778
p.H948Q	DO223947	KIRP	ICGC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.2778
p.Y953F	TCGA-66-2755	LUSC	TCGA	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1389
p.Y953F	DO27365	LUSC	ICGC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1389
p.R951H	TCGA-A5-A0G1	UCEC	TCGA	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1944
p.R951H	DO42472	UCEC	ICGC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1944
p.R952H	TCGA-A5-A1OF	UCEC	TCGA	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1667
p.R952H	DO42568	UCEC	ICGC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1667
p.P937H	TCGA-AX-A2HD	UCEC	TCGA	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1667
p.P937H	DO42608	UCEC	ICGC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1667
p.E24K	TCGA-CN-A498	HNSC	TCGA	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation rewiring degron network	0.0833
p.E24K	DO52038	HNSC	ICGC	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation rewiring degron network	0.0833
p.L191F	TCGA-D3-A3C7	SKCM	TCGA	VTPDIE	DEG_SCF_FBW7_2	200:205	Mutation rewiring degron network	0.0833
p.L191F	DO47569	SKCM	ICGC	VTPDIE	DEG_SCF_FBW7_2	200:205	Mutation rewiring degron network	0.0833
p.D10Y	TCGA-EA-A3HU	CESC	TCGA	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation altering degron motif	0.7325
p.D10Y	DO6320	CESC	ICGC	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation altering degron motif	0.7325
p.L5M	TCGA-EE-A2M5	SKCM	TCGA	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation rewiring degron network	0.1944
p.L5M	DO37425	SKCM	ICGC	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation rewiring degron network	0.1944
p.S596F	TCGA-GN-A266	SKCM	TCGA	VKTTS	DEG_SPOP_SBC_1	585:589	Mutation rewiring degron network	0.1389
p.S596F	DO37432	SKCM	ICGC	VKTTS	DEG_SPOP_SBC_1	585:589	Mutation rewiring degron network	0.1389
p.H942Y	TCGA-OL-A5RW	BRCA	TCGA	PPPY	ITCH	943:946	Mutation rewiring degron network	0.3056
p.H942Y	DO44238	BRCA	ICGC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.3056
p.R951C	TCGA-VQ-A8PM	STAD	TCGA	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1944
p.R951C	DO51772	STAD	ICGC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1944
p.T950P	DO48394	BLCA	ICGC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.2222
p.T950P	DO23438	LINC	ICGC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.2222
p.T950P	DO229144	THCA	ICGC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.2222
p.T950P	KYAE-1	oesophagus	COSMIC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.2222
p.T950P	NCI-H720	lung	COSMIC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.2222
p.T950P	RPMI-2650	upper aerodigestive tract	COSMIC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.2222
p.T950P	Hs-445	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.2222
p.P13H	DO233871	GACA	ICGC	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation altering degron motif	0.6583
p.F198L	DO229041	LICA	ICGC	VTPDIE	DEG_SCF_FBW7_2	200:205	Mutation rewiring degron network	0.2778
p.S595R	DO229006	LICA	ICGC	VKTTS	DEG_SPOP_SBC_1	585:589	Mutation rewiring degron network	0.1667
p.T15K	DO229008	LICA	ICGC	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation altering degron motif	0.7306
p.S591F	DO229224	THCA	ICGC	VKTTS	DEG_SPOP_SBC_1	585:589	Mutation blocking phosphorylation signal	0.7222
p.V200A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VTPDIE	DEG_SCF_FBW7_2	200:205	Mutation altering degron motif	0.6936
p.V200A	ACH-002256	Leukemia	CCLE	VTPDIE	DEG_SCF_FBW7_2	200:205	Mutation altering degron motif	0.6936
p.V200A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VTPDIE	DEG_SCF_FBW7_2	200:205	Mutation altering degron motif	0.6936
p.R590K	SIDM00259	Neuroblastoma	GDSC	VKTTS	DEG_SPOP_SBC_1	585:589	Mutation rewiring degron network	0.3056
p.R590K	ACH-002278	Neuroblastoma	CCLE	VKTTS	DEG_SPOP_SBC_1	585:589	Mutation rewiring degron network	0.3056
p.R590K	NB10	autonomic ganglia	COSMIC	VKTTS	DEG_SPOP_SBC_1	585:589	Mutation rewiring degron network	0.3056
p.V936F	SIDM01133	Other Solid Cancers	GDSC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1389
p.V936F	ACH-002177	Lung Cancer	CCLE	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1389
p.V936F	NCI-H835	lung	COSMIC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.1389
p.G12D	SIDM00954	Breast Carcinoma	GDSC	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation altering degron motif	0.7198
p.G12D	ACH-001820	Breast Cancer	CCLE	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation altering degron motif	0.7198
p.S577L	SIDM00217	Colorectal Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	585:589	Mutation rewiring degron network	0.1111
p.S577L	ACH-000999	Colon/Colorectal Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	585:589	Mutation rewiring degron network	0.1111
p.S577L	SNU-1040	large intestine	COSMIC	VKTTS	DEG_SPOP_SBC_1	585:589	Mutation rewiring degron network	0.1111
p.P202L	SIDM00783	Colorectal Carcinoma	GDSC	VTPDIE	DEG_SCF_FBW7_2	200:205	Mutation altering degron motif	0.7582
p.G21D	SIDM01609	Endometrial Carcinoma	GDSC	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation rewiring degron network	0.1667
p.G21D	ACH-000972	Endometrial/Uterine Cancer	CCLE	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation rewiring degron network	0.1667
p.P20Q	SIDM01619	Endometrial Carcinoma	GDSC	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation rewiring degron network	0.1944
p.P20Q	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGPGT	DEG_SCF_TRCP1_1	10:15	Mutation rewiring degron network	0.1944
p.F949S	L-540	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	943:946	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SAFB2

UniProt ID: Q14151

Entrez ID: 9667

Protein name: Scaffold attachment factor B2 (SAF-B2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SAFB2 in