DegronMD

Uniprot ID: Q14151

Source protein: Scaffold attachment factor B2

Source gene: SAFB2

Class: DEG_SCF_TRCP1_1

Location: 10:15

E3 ligase: BTRC

DEGRON score: 0.9594

ASA_SCORE: 70.75

COIL: 0.8848

CONS_SCORE: 0.122

DSS_SCORE: 0.6984

HELIX: 0.0457

FCONS_SCORE: 0.4274

RIG_SCORE: 0.5257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E24K	TCGA-CN-A498	HNSC	TCGA	DSGPGT	DEG_SCF_TRCP1_1	0.0833
p.E24K	DO52038	HNSC	ICGC	DSGPGT	DEG_SCF_TRCP1_1	0.0833
p.D10Y	TCGA-EA-A3HU	CESC	TCGA	DSGPGT	DEG_SCF_TRCP1_1	0.7325
p.D10Y	DO6320	CESC	ICGC	DSGPGT	DEG_SCF_TRCP1_1	0.7325
p.L5M	TCGA-EE-A2M5	SKCM	TCGA	DSGPGT	DEG_SCF_TRCP1_1	0.1944
p.L5M	DO37425	SKCM	ICGC	DSGPGT	DEG_SCF_TRCP1_1	0.1944
p.P13H	DO233871	GACA	ICGC	DSGPGT	DEG_SCF_TRCP1_1	0.6583
p.T15K	DO229008	LICA	ICGC	DSGPGT	DEG_SCF_TRCP1_1	0.7306
p.G12D	SIDM00954	Breast Carcinoma	GDSC	DSGPGT	DEG_SCF_TRCP1_1	0.7198
p.G12D	ACH-001820	Breast Cancer	CCLE	DSGPGT	DEG_SCF_TRCP1_1	0.7198
p.G21D	SIDM01609	Endometrial Carcinoma	GDSC	DSGPGT	DEG_SCF_TRCP1_1	0.1667
p.G21D	ACH-000972	Endometrial/Uterine Cancer	CCLE	DSGPGT	DEG_SCF_TRCP1_1	0.1667
p.P20Q	SIDM01619	Endometrial Carcinoma	GDSC	DSGPGT	DEG_SCF_TRCP1_1	0.1944
p.P20Q	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGPGT	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14151	Scaffold attachment factor B2	DEG_SCF_TRCP1_1	10:15	DSGPGT	BTRC	0.9594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons