DegronMD

Uniprot ID: Q14151

Source protein: Scaffold attachment factor B2

Source gene: SAFB2

Class: DEG_SCF_FBW7_2

Location: 200:205

E3 ligase: FBXW7

DEGRON score: 0.9271

ASA_SCORE: 76.3333

COIL: 0.726

CONS_SCORE: 0.3125

DSS_SCORE: 0.48

HELIX: 0.2263

FCONS_SCORE: 0.9185

RIG_SCORE: 0.807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S207Y	TCGA-49-4487	LUAD	TCGA	VTPDIE	DEG_SCF_FBW7_2	0.7222
p.S207Y	DO24780	LUAD	ICGC	VTPDIE	DEG_SCF_FBW7_2	0.7222
p.L191F	TCGA-D3-A3C7	SKCM	TCGA	VTPDIE	DEG_SCF_FBW7_2	0.0833
p.L191F	DO47569	SKCM	ICGC	VTPDIE	DEG_SCF_FBW7_2	0.0833
p.F198L	DO229041	LICA	ICGC	VTPDIE	DEG_SCF_FBW7_2	0.2778
p.V200A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VTPDIE	DEG_SCF_FBW7_2	0.6936
p.V200A	ACH-002256	Leukemia	CCLE	VTPDIE	DEG_SCF_FBW7_2	0.6936
p.V200A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VTPDIE	DEG_SCF_FBW7_2	0.6936
p.P202L	SIDM00783	Colorectal Carcinoma	GDSC	VTPDIE	DEG_SCF_FBW7_2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14151	Scaffold attachment factor B2	DEG_SCF_FBW7_2	200:205	VTPDIE	FBXW7	0.9271	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons