DegronMD

Uniprot ID: Q08345

Source protein: Epithelial discoidin domain-containing receptor 1

Source gene: DDR1

Class: ITCH

Location: 481:484

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9509

ASA_SCORE: 78.175

COIL: 0.9023

CONS_SCORE: 0.4863

DSS_SCORE: 0.8001

HELIX: 0.0335

FCONS_SCORE: 1.2033

RIG_SCORE: 0.5728

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P482H	TCGA-18-3421	LUSC	TCGA	PPPY	ITCH	0.7694
p.P482H	DO27652	LUSC	ICGC	PPPY	ITCH	0.7694
p.P487L	TCGA-6A-AB49	LUSC	TCGA	PPPY	ITCH	0.25
p.P487L	DO52020	LUSC	ICGC	PPPY	ITCH	0.25
p.R475C	TCGA-AJ-A8CW	UCEC	TCGA	PPPY	ITCH	0.1667
p.E480K	TCGA-AN-A046	BRCA	TCGA	PPPY	ITCH	0.3056
p.E480K	DO1285	BRCA	ICGC	PPPY	ITCH	0.3056
p.R488Q	TCGA-B5-A1MX	UCEC	TCGA	PPPY	ITCH	0.2222
p.R488Q	DO41999	UCEC	ICGC	PPPY	ITCH	0.2222
p.R488Q	SIDM01062	Breast Carcinoma	GDSC	PPPY	ITCH	0.2222
p.R488Q	HDQ-P1	breast	COSMIC	PPPY	ITCH	0.2222
p.P493L	TCGA-D3-A8GI	SKCM	TCGA	PPPY	ITCH	0.0833
p.P483S	TCGA-EE-A29M	SKCM	TCGA	PPPY	ITCH	0.5641
p.P483S	TCGA-FS-A1ZW	SKCM	TCGA	PPPY	ITCH	0.5641
p.P483S	DO37519	SKCM	ICGC	PPPY	ITCH	0.5641
p.P483S	DO37404	SKCM	ICGC	PPPY	ITCH	0.5641
p.P483L	TCGA-EE-A29M	SKCM	TCGA	PPPY	ITCH	0.6471
p.P483L	TCGA-FS-A1ZW	SKCM	TCGA	PPPY	ITCH	0.6471
p.G477C	TCGA-EY-A215	UCEC	TCGA	PPPY	ITCH	0.2222
p.E486K	TCGA-XT-AASU	MESO	TCGA	PPPY	ITCH	0.2778
p.R490H	DO233267	GACA	ICGC	PPPY	ITCH	0.1667
p.E480Q	DO229266	LMS	ICGC	PPPY	ITCH	0.3056
p.V472M	ACH-000767	Lung Cancer	CCLE	PPPY	ITCH	0.0833
p.V472M	NCI-H526	lung	COSMIC	PPPY	ITCH	0.0833
p.D484E	OVMIU	ovary	COSMIC	PPPY	ITCH	0.6758

Drug responses associated with DDR1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00996	THCA\|thyroid	p.R262H (No)	GDSC	QL-XI-92	43.986
SIDM01194	LIHC\|liver	p.F670L (No)	GDSC	QL-XI-92	57.4425
SIDM00130	PAAD\|pancreas	p.A226V (No)	GDSC	QL-XI-92	40.1185
SIDM00889	CESC\|cervix	p.R169fs*6 (No)	GDSC	QL-XI-92	66.5404
SIDM01164	LGG\|glioma	p.R525Q (No)	GDSC	QL-XI-92	79.7665
SIDM00190	SKCM\|melanoma	p.V826M (No)	GDSC	QL-XI-92	102.0208
SIDM00210	UNCLASSIFIED\|ovary	p.S17G (No)	GDSC	QL-XI-92	12.7643
SIDM00499	PRAD\|prostate	p.R276Q (No)	GDSC	QL-XI-92	64.6773
SIDM01032	ESCA\|oesophagus	p.P301L (No)	GDSC	QL-XI-92	9.2908
SIDM01032	ESCA\|oesophagus	p.R686L (No)	GDSC	QL-XI-92	9.2908
SIDM01187	BRCA\|breast	p.A226V (No)	GDSC	QL-XI-92	166.4588
SIDM00590	HNSC\|head_and_neck	p.D367_V369delinsE (No)	GDSC	QL-XI-92	71.2977
SIDM00461	LAML\|acute_myeloid_leukaemia	p.S360R (No)	GDSC	QL-XI-92	2.5257
SIDM00461	LAML\|acute_myeloid_leukaemia	p.Q280R (No)	GDSC	QL-XI-92	2.5257
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.M311V (No)	GDSC	QL-XI-92	61.784
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q749* (No)	GDSC	QL-XI-92	17.1142
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.R248Q (No)	GDSC	QL-XI-92	31.6663
SIDM00326	ESCA\|oesophagus	p.R248Q (No)	GDSC	QL-XI-92	76.5123
SIDM00856	UNCLASSIFIED\|kidney	p.R60C (No)	GDSC	QL-XI-92	24.5761
SIDM00214	COREAD\|large_intestine	p.A353V (No)	GDSC	QL-XI-92	170.5025
SIDM00732	GBM\|glioma	p.R349C (No)	GDSC	QL-XI-92	171.2345
SIDM01090	COREAD\|large_intestine	p.A59G (No)	GDSC	QL-XI-92	16.8312
SIDM00156	NB\|neuroblastoma	p.P299Q (No)	GDSC	QL-XI-92	14.2463
SIDM01055	LGG\|glioma	p.R319C (No)	GDSC	QL-XI-92	7.545
SIDM00211	ALL\|lymphoblastic_leukemia	p.A58P (No)	GDSC	QL-XI-92	9.1318
SIDM00590	HNSC\|head_and_neck	p.*442K (No)	GDSC	QL-XI-92	71.2977
SIDM00217	COREAD\|large_intestine	p.G108R (No)	GDSC	QL-XI-92	32.2874
SIDM00217	COREAD\|large_intestine	p.R755H (No)	GDSC	QL-XI-92	32.2874
SIDM00889	CESC\|cervix	p.R248W (No)	GDSC	QL-XI-92	66.5404
SIDM00839	COREAD\|large_intestine	p.V100A (No)	GDSC	QL-XI-92	125.377
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V454M (No)	GDSC	QL-XI-92	105.9401
SIDM00596	UCEC\|endometrium	p.T292M (No)	GDSC	QL-XI-92	111.2823
SIDM01196	LIHC\|liver	p.R248W (No)	GDSC	QL-XI-92	30.4666
SIDM00321	UNCLASSIFIED\|ovary	p.A196S (No)	GDSC	QL-XI-92	104.5075
SIDM00238	OV\|ovary	p.P483fs*170 (Yes)	GDSC	QL-XI-92	71.7101
SIDM00128	HNSC\|head_and_neck	p.A226V (No)	GDSC	QL-XI-92	44.9394
SIDM00996	THCA\|thyroid	p.F670L (No)	GDSC	QL-XI-92	43.986
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Q280R (No)	GDSC	QL-XI-92	3.8904
SIDM00737	UNCLASSIFIED\|lung_NSCLC_not_specified	p.R862W (No)	GDSC	QL-XI-92	135.361
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.L679P (No)	GDSC	QL-XI-92	74.2181
SIDM00458	LAML\|acute_myeloid_leukaemia	p.S17G (No)	GDSC	QL-XI-92	6.1739
SIDM00609	KIRC\|kidney	p.P43T (No)	GDSC	QL-XI-92	165.7149
SIDM00534	COREAD\|large_intestine	p.R755C (No)	GDSC	QL-XI-92	123.5537
SIDM00534	COREAD\|large_intestine	p.R436I (No)	GDSC	QL-XI-92	123.5537
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P381S (No)	GDSC	QL-XI-92	389.9541
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.H25R (No)	GDSC	QL-XI-92	7.417
SIDM01087	SKCM\|melanoma	p.L557R (No)	GDSC	QL-XI-92	10.6597
SIDM00569	UNCLASSIFIED\|osteosarcoma	p.W286S (No)	GDSC	QL-XI-92	185.239
SIDM00465	OV\|ovary	p.D630E (No)	GDSC	QL-XI-92	36.5257
SIDM00604	HNSC\|head_and_neck	p.R262H (No)	GDSC	QL-XI-92	95.3974
SIDM00572	STAD\|stomach	p.T531fs*122 (No)	GDSC	QL-XI-92	153.671
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.A226V (No)	GDSC	QL-XI-92	5.9094
SIDM00837	COREAD\|large_intestine	p.I684T (No)	GDSC	QL-XI-92	138.4959
SIDM00115	HNSC\|head_and_neck	p.H300P (No)	GDSC	QL-XI-92	65.2617
SIDM01062	BRCA\|breast	p.R488Q (Yes)	GDSC	QL-XI-92	114.1766
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.A226V (No)	GDSC	QL-XI-92	73.0485
SIDM00424	UNCLASSIFIED\|B_cell_leukemia	p.W187C (No)	GDSC	QL-XI-92	58.6595
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.D795E (No)	GDSC	QL-XI-92	23.6282
SIDM00284	SKCM\|melanoma	p.F241L (No)	GDSC	QL-XI-92	47.4277
SIDM00118	COREAD\|large_intestine	p.E250* (No)	GDSC	QL-XI-92	101.0808
SIDM00608	MM\|myeloma	p.P806L (No)	GDSC	QL-XI-92	17.0624

All proteins holding degron of PPPY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NK58	Putative lipoyltransferase 2, mitochondrial	ITCH	139:142	PPPY	ITCH,NEDD4	0.8475	More...
O00512	B-cell CLL/lymphoma 9 protein	ITCH	515:518	PPPY	ITCH,NEDD4	0.9973	More...
O14559	Rho GTPase-activating protein 33	ITCH	966:969	PPPY	ITCH,NEDD4	0.7553	More...
O14559	Rho GTPase-activating protein 33	ITCH	1267:1270	PPPY	ITCH,NEDD4	0.8377	More...
O14641	Segment polarity protein dishevelled homolog DVL-2	ITCH	565:568	PPPY	ITCH,NEDD4	0.9448	More...
O14669	Transmembrane gamma-carboxyglutamic acid protein 2	ITCH	192:195	PPPY	ITCH,NEDD4	0.9966	More...
O14795	Protein unc-13 homolog B	ITCH	200:203	PPPY	ITCH,NEDD4	0.9976	More...
O15047	Histone-lysine N-methyltransferase SETD1A	ITCH	614:617	PPPY	ITCH,NEDD4	0.9788	More...
O15049	NEDD4-binding protein 3	ITCH	245:248	PPPY	ITCH,NEDD4	0.9279	More...
O15054	Lysine-specific demethylase 6B	ITCH	573:576	PPPY	ITCH,NEDD4	0.7712	More...
O15072	A disintegrin and metalloproteinase with thrombospondin motifs 3	ITCH	1058:1061	PPPY	ITCH,NEDD4	0.9797	More...
O15165	Low-density lipoprotein receptor class A domain-containing protein 4	ITCH	180:183	PPPY	ITCH,NEDD4	0.9111	More...
O15350	Tumor protein p73	ITCH	484:487	PPPY	ITCH,NEDD4	0.6964	More...
O43182	Rho GTPase-activating protein 6	ITCH	881:884	PPPY	ITCH,NEDD4	0.929	More...
O43541	Mothers against decapentaplegic homolog 6	ITCH	276:279	PPPY	ITCH,NEDD4	0.5177	More...
O94850	Dendrin	ITCH	224:227	PPPY	ITCH,NEDD4	0.9946	More...
O95395	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3	ITCH	285:288	PPPY	ITCH,NEDD4	0.5532	More...
O95415	Brain protein I3	ITCH	39:42	PPPY	ITCH,NEDD4	0.9496	More...
O95835	Serine/threonine-protein kinase LATS1	ITCH	373:376	PPPY	ITCH,NEDD4	0.9971	More...
O95835	Serine/threonine-protein kinase LATS1	ITCH	556:559	PPPY	ITCH,NEDD4	0.9214	More...
O96028	Histone-lysine N-methyltransferase NSD2	ITCH	988:991	PPPY	ITCH,NEDD4	0.9082	More...
P02751	Fibronectin	ITCH	302:305	PPPY	ITCH,NEDD4	0.7954	More...
P02814	Submaxillary gland androgen-regulated protein 3B	ITCH	51:54	PPPY	ITCH,NEDD4	0.7998	More...
P05549	Transcription factor AP-2-alpha	ITCH	59:62	PPPY	ITCH,NEDD4	0.9994	More...
P20936	Ras GTPase-activating protein 1	ITCH	139:142	PPPY	ITCH,NEDD4	0.9905	More...
P48634	Protein PRRC2A	ITCH	262:265	PPPY	ITCH,NEDD4	0.5977	More...
P48634	Protein PRRC2A	ITCH	831:834	PPPY	ITCH,NEDD4	0.9976	More...
P54259	Atrophin-1	ITCH	445:448	PPPY	ITCH,NEDD4	0.973	More...
P54259	Atrophin-1	ITCH	636:639	PPPY	ITCH,NEDD4	0.9909	More...
P57082	T-box transcription factor TBX4	ITCH	370:373	PPPY	ITCH,NEDD4	0.9887	More...
P98153	Integral membrane protein DGCR2/IDD	ITCH	430:433	PPPY	ITCH,NEDD4	0.923	More...
P98153	Integral membrane protein DGCR2/IDD	ITCH	448:451	PPPY	ITCH,NEDD4	0.7303	More...
Q01196	Runt-related transcription factor 1	ITCH	355:358	PPPY	ITCH,NEDD4	0.9852	More...
Q06416	Putative POU domain, class 5, transcription factor 1B	ITCH	64:67	PPPY	ITCH,NEDD4	0.6899	More...
Q08345	Epithelial discoidin domain-containing receptor 1	ITCH	481:484	PPPY	ITCH,NEDD4	0.9509	More...
Q12951	Forkhead box protein I1	ITCH	72:75	PPPY	ITCH,NEDD4	0.6272	More...
Q13017	Rho GTPase-activating protein 5	ITCH	988:991	PPPY	ITCH,NEDD4	0.9581	More...
Q13480	GRB2-associated-binding protein 1	ITCH	159:162	PPPY	ITCH,NEDD4	0.9888	More...
Q13571	Lysosomal-associated transmembrane protein 5	ITCH	256:259	PPPY	ITCH,NEDD4	0.8015	More...
Q13573	SNW domain-containing protein 1	ITCH	41:44	PPPY	ITCH,NEDD4	0.999	More...
Q13625	Apoptosis-stimulating of p53 protein 2	ITCH	871:874	PPPY	ITCH,NEDD4	0.9885	More...
Q13635	Protein patched homolog 1	ITCH	1313:1316	PPPY	ITCH,NEDD4	0.9833	More...
Q13761	Runt-related transcription factor 3	ITCH	309:312	PPPY	ITCH,NEDD4	0.9935	More...
Q13950	Runt-related transcription factor 2	ITCH	423:426	PPPY	ITCH,NEDD4	0.9888	More...
Q14112	Nidogen-2	ITCH	411:414	PPPY	ITCH,NEDD4	0.9797	More...
Q14118	Dystroglycan 1	ITCH	889:892	PPPY	ITCH,NEDD4	0.9988	More...
Q14151	Scaffold attachment factor B2	ITCH	943:946	PPPY	ITCH,NEDD4	0.9012	More...
Q14686	Nuclear receptor coactivator 6	ITCH	373:376	PPPY	ITCH,NEDD4	0.9837	More...
Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	ITCH	51:54	PPPY	ITCH,NEDD4	0.9539	More...
Q15012	Lysosomal-associated transmembrane protein 4A	ITCH	227:230	PPPY	ITCH,NEDD4	0.8271	More...
Q15018	BRISC complex subunit Abraxas 2	ITCH	305:308	PPPY	ITCH,NEDD4	0.9939	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	ITCH	1298:1301	PPPY	ITCH,NEDD4	0.9446	More...
Q15427	Splicing factor 3B subunit 4	ITCH	391:394	PPPY	ITCH,NEDD4	0.9915	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	ITCH	567:570	PPPY	ITCH,NEDD4	0.9991	More...
Q16534	Hepatic leukemia factor	ITCH	16:19	PPPY	ITCH,NEDD4	0.8832	More...
Q16621	Transcription factor NF-E2 45 kDa subunit	ITCH	80:83	PPPY	ITCH,NEDD4	0.9539	More...
Q16625	Occludin	ITCH	9:12	PPPY	ITCH,NEDD4	0.8621	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	ITCH	387:390	PPPY	ITCH,NEDD4	0.9919	More...
Q16655	Melanoma antigen recognized by T-cells 1	ITCH	113:116	PPPY	ITCH,NEDD4	0.8685	More...
Q16825	Tyrosine-protein phosphatase non-receptor type 21	ITCH	566:569	PPPY	ITCH,NEDD4	0.9701	More...
Q5JU85	IQ motif and SEC7 domain-containing protein 2	ITCH	1279:1282	PPPY	ITCH,NEDD4	0.5604	More...
Q6GQQ9	OTU domain-containing protein 7B	ITCH	766:769	PPPY	ITCH,NEDD4	0.95	More...
Q6UUV7	CREB-regulated transcription coactivator 3	ITCH	445:448	PPPY	ITCH,NEDD4	0.998	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	ITCH	647:650	PPPY	ITCH,NEDD4	0.8809	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	ITCH	803:806	PPPY	ITCH,NEDD4	0.9637	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	ITCH	1117:1120	PPPY	ITCH,NEDD4	0.9484	More...
Q86T03	Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	ITCH	65:68	PPPY	ITCH,NEDD4	0.9965	More...
Q86U86	Protein polybromo-1	ITCH	1572:1575	PPPY	ITCH,NEDD4	0.9838	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	ITCH	561:564	PPPY	ITCH,NEDD4	0.9923	More...
Q86UU5	Gametogenetin	ITCH	338:341	PPPY	ITCH,NEDD4	0.9878	More...
Q86X29	Lipolysis-stimulated lipoprotein receptor	ITCH	620:623	PPPY	ITCH,NEDD4	0.9992	More...
Q86YD5	Low-density lipoprotein receptor class A domain-containing protein 3	ITCH	275:278	PPPY	ITCH,NEDD4	0.997	More...
Q8IV31	Transmembrane protein 139	ITCH	111:114	PPPY	ITCH,NEDD4	0.9962	More...
Q8N1I0	Dedicator of cytokinesis protein 4	ITCH	1900:1903	PPPY	ITCH,NEDD4	0.9993	More...
Q8N448	Ligand of Numb protein X 2	ITCH	445:448	PPPY	ITCH,NEDD4	0.9565	More...
Q8N4L2	Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	ITCH	39:42	PPPY	ITCH,NEDD4	0.9985	More...
Q8NB59	Synaptotagmin-14	ITCH	165:168	PPPY	ITCH,NEDD4	0.9976	More...
Q8NBF1	Zinc finger protein GLIS1	ITCH	165:168	PPPY	ITCH,NEDD4	0.9994	More...
Q8NEA6	Zinc finger protein GLIS3	ITCH	304:307	PPPY	ITCH,NEDD4	0.5841	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	ITCH	2436:2439	PPPY	ITCH,NEDD4	0.986	More...
Q8NI35	InaD-like protein	ITCH	1202:1205	PPPY	ITCH,NEDD4	0.9952	More...
Q8TB68	Proline-rich protein 7	ITCH	163:166	PPPY	ITCH,NEDD4	0.8954	More...
Q8TEB9	Rhomboid-related protein 4	ITCH	292:295	PPPY	ITCH,NEDD4	0.9941	More...
Q8TF74	WAS/WASL-interacting protein family member 2	ITCH	252:255	PPPY	ITCH,NEDD4	0.9988	More...
Q8TF74	WAS/WASL-interacting protein family member 2	ITCH	343:346	PPPY	ITCH,NEDD4	0.9981	More...
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	ITCH	704:707	PPPY	ITCH,NEDD4	0.9478	More...
Q8WXX7	Autism susceptibility gene 2 protein	ITCH	516:519	PPPY	ITCH,NEDD4	0.9979	More...
Q92481	Transcription factor AP-2-beta	ITCH	71:74	PPPY	ITCH,NEDD4	0.9974	More...
Q92567	Protein FAM168A	ITCH	120:123	PPPY	ITCH,NEDD4	0.5413	More...
Q92574	Hamartin	ITCH	601:604	PPPY	ITCH,NEDD4	0.9978	More...
Q92754	Transcription factor AP-2 gamma	ITCH	56:59	PPPY	ITCH,NEDD4	0.997	More...
Q92754	Transcription factor AP-2 gamma	ITCH	61:64	PPPY	ITCH,NEDD4	0.9784	More...
Q92922	SWI/SNF complex subunit SMARCC1	ITCH	996:999	PPPY	ITCH,NEDD4	0.8735	More...
Q969F2	Protein naked cuticle homolog 2	ITCH	377:380	PPPY	ITCH,NEDD4	0.8617	More...
Q969T9	WW domain-binding protein 2	ITCH	197:200	PPPY	ITCH,NEDD4	0.8658	More...
Q969T9	WW domain-binding protein 2	ITCH	249:252	PPPY	ITCH,NEDD4	0.8392	More...
Q969W9	Protein TMEPAI	ITCH	158:161	PPPY	ITCH,NEDD4	0.866	More...
Q969X1	Protein lifeguard 3	ITCH	7:10	PPPY	ITCH,NEDD4	0.9981	More...
Q96AW1	Vesicular, overexpressed in cancer, prosurvival protein 1	ITCH	162:165	PPPY	ITCH,NEDD4	0.8528	More...
Q96CS7	Pleckstrin homology domain-containing family B member 2	ITCH	129:132	PPPY	ITCH,NEDD4	0.9875	More...
Q96DF8	Splicing factor ESS-2 homolog	ITCH	99:102	PPPY	ITCH,NEDD4	0.9959	More...
Q96DV4	39S ribosomal protein L38, mitochondrial	ITCH	347:350	PPPY	ITCH,NEDD4	0.6466	More...
Q96HA8	Protein N-terminal glutamine amidohydrolase	ITCH	160:163	PPPY	ITCH,NEDD4	0.832	More...
Q96JG9	Zinc finger protein 469	ITCH	709:712	PPPY	ITCH,NEDD4	0.9932	More...
Q96KN3	Homeobox protein PKNOX2	ITCH	21:24	PPPY	ITCH,NEDD4	0.9792	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	ITCH	1867:1870	PPPY	ITCH,NEDD4	0.9381	More...
Q96PK6	RNA-binding protein 14	ITCH	573:576	PPPY	ITCH,NEDD4	0.9849	More...
Q96SZ6	Mitochondrial tRNA methylthiotransferase CDK5RAP1	ITCH	86:89	PPPY	ITCH,NEDD4	0.9857	More...
Q96T58	Msx2-interacting protein	ITCH	2236:2239	PPPY	ITCH,NEDD4	0.9808	More...
Q99935	Opiorphin prepropeptide	ITCH	50:53	PPPY	ITCH,NEDD4	0.9027	More...
Q99946	Proline-rich transmembrane protein 1	ITCH	17:20	PPPY	ITCH,NEDD4	0.9917	More...
Q9BT67	NEDD4 family-interacting protein 1	ITCH	39:42	PPPY	ITCH,NEDD4	0.9967	More...
Q9BTC0	Death-inducer obliterator 1	ITCH	1817:1820	PPPY	ITCH,NEDD4	0.9967	More...
Q9BZ95	Histone-lysine N-methyltransferase NSD3	ITCH	1070:1073	PPPY	ITCH,NEDD4	0.6146	More...
Q9BZD6	Transmembrane gamma-carboxyglutamic acid protein 4	ITCH	204:207	PPPY	ITCH,NEDD4	0.8437	More...
Q9BZJ3	Tryptase delta	ITCH	177:180	PPPY	ITCH,NEDD4	0.5629	More...
Q9GZV9	Fibroblast growth factor 23	ITCH	151:154	PPPY	ITCH,NEDD4	0.9815	More...
Q9H0F5	E3 ubiquitin-protein ligase RNF38	ITCH	381:384	PPPY	ITCH,NEDD4	0.9052	More...
Q9H2G4	Testis-specific Y-encoded-like protein 2	ITCH	73:76	PPPY	ITCH,NEDD4	0.7605	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9945	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	51:54	PPPY	ITCH,NEDD4	0.9943	More...
Q9H3D4	Tumor protein 63	ITCH	540:543	PPPY	ITCH,NEDD4	0.9417	More...
Q9HCM1	Retroelement silencing factor 1	ITCH	279:282	PPPY	ITCH,NEDD4	0.9514	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	ITCH	963:966	PPPY	ITCH,NEDD4	0.9689	More...
Q9NQC3	Reticulon-4	ITCH	656:659	PPPY	ITCH,NEDD4	0.9958	More...
Q9NRJ4	Tubby-related protein 4	ITCH	834:837	PPPY	ITCH,NEDD4	0.9893	More...
Q9NRJ4	Tubby-related protein 4	ITCH	958:961	PPPY	ITCH,NEDD4	0.9994	More...
Q9NRJ4	Tubby-related protein 4	ITCH	1119:1122	PPPY	ITCH,NEDD4	0.989	More...
Q9NRM7	Serine/threonine-protein kinase LATS2	ITCH	515:518	PPPY	ITCH,NEDD4	0.9941	More...
Q9NRR2	Tryptase gamma	ITCH	174:177	PPPY	ITCH,NEDD4	0.5927	More...
Q9NRY6	Phospholipid scramblase 3	ITCH	15:18	PPPY	ITCH,NEDD4	0.9037	More...
Q9NV92	NEDD4 family-interacting protein 2	ITCH	148:151	PPPY	ITCH,NEDD4	0.9623	More...
Q9NV92	NEDD4 family-interacting protein 2	ITCH	174:177	PPPY	ITCH,NEDD4	0.9994	More...
Q9NX94	WW domain binding protein 1-like	ITCH	119:122	PPPY	ITCH,NEDD4	0.9937	More...
Q9NYG2	Palmitoyltransferase ZDHHC3	ITCH	26:29	PPPY	ITCH,NEDD4	0.669	More...
Q9NZ81	Proline-rich protein 13	ITCH	78:81	PPPY	ITCH,NEDD4	0.9396	More...
Q9UIS9	Methyl-CpG-binding domain protein 1	ITCH	400:403	PPPY	ITCH,NEDD4	0.7098	More...
Q9UKN5	PR domain zinc finger protein 4	ITCH	94:97	PPPY	ITCH,NEDD4	0.6746	More...
Q9UM47	Neurogenic locus notch homolog protein 3	ITCH	2208:2211	PPPY	ITCH,NEDD4	0.8622	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	ITCH	2292:2295	PPPY	ITCH,NEDD4	0.9949	More...
Q9UMS6	Synaptopodin-2	ITCH	619:622	PPPY	ITCH,NEDD4	0.9793	More...
Q9UPP2	IQ motif and SEC7 domain-containing protein 3	ITCH	1153:1156	PPPY	ITCH,NEDD4	0.8368	More...
Q9UPW8	Protein unc-13 homolog A	ITCH	210:213	PPPY	ITCH,NEDD4	0.9992	More...
Q9UPZ9	Serine/threonine-protein kinase ICK	ITCH	313:316	PPPY	ITCH,NEDD4	0.9808	More...
Q9Y3C5	RING finger protein 11	ITCH	37:40	PPPY	ITCH,NEDD4	0.9962	More...
Q9Y5W3	Krueppel-like factor 2	ITCH	81:84	PPPY	ITCH,NEDD4	0.9881	More...
Q9Y6W3	Calpain-7	ITCH	624:627	PPPY	ITCH,NEDD4	0.5393	More...
A0PJX4	Protein shisa-3 homolog	ITCH	193:196	PPPY	ITCH,NEDD4	0.9853	More...
P81408	Protein FAM189B	ITCH	247:250	PPPY	ITCH,NEDD4	0.9784	More...
Q6UWW9	Transmembrane protein 207	ITCH	136:139	PPPY	ITCH,NEDD4	0.8536	More...
Q6VUC0	Transcription factor AP-2-epsilon	ITCH	56:59	PPPY	ITCH,NEDD4	0.9747	More...
Q8WUU8	Transmembrane protein 174	ITCH	232:235	PPPY	ITCH,NEDD4	0.8353	More...
Q96DD7	Protein shisa-4	ITCH	184:187	PPPY	ITCH,NEDD4	0.9835	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	113:116	PPPY	ITCH,NEDD4	0.9396	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	129:132	PPPY	ITCH,NEDD4	0.9428	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	145:148	PPPY	ITCH,NEDD4	0.9794	More...
Q99954	Submaxillary gland androgen-regulated protein 3A	ITCH	55:58	PPPY	ITCH,NEDD4	0.8844	More...
Q99954	Submaxillary gland androgen-regulated protein 3A	ITCH	81:84	PPPY	ITCH,NEDD4	0.5816	More...
Q99954	Submaxillary gland androgen-regulated protein 3A	ITCH	95:98	PPPY	ITCH,NEDD4	0.9262	More...
Q9P203	BTB/POZ domain-containing protein 7	ITCH	762:765	PPPY	ITCH,NEDD4	0.9575	More...
Q9P242	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2	ITCH	454:457	PPPY	ITCH,NEDD4	0.9992	More...
O60320	Protein FAM189A1	ITCH	246:249	PPPY	ITCH,NEDD4	0.9766	More...
O60320	Protein FAM189A1	ITCH	295:298	PPPY	ITCH,NEDD4	0.5238	More...
Q15884	Protein FAM189A2	ITCH	194:197	PPPY	ITCH,NEDD4	0.9938	More...
Q3B7T3	Protein BEAN1	ITCH	166:169	PPPY	ITCH,NEDD4	0.9146	More...
Q5JRV8	Transmembrane protein 255A	ITCH	344:347	PPPY	ITCH,NEDD4	0.6405	More...
Q6UXU6	Transmembrane protein 92	ITCH	117:120	PPPY	ITCH,NEDD4	0.54	More...
Q6UXU6	Transmembrane protein 92	ITCH	137:140	PPPY	ITCH,NEDD4	0.5673	More...
Q7L0R7	RING finger protein 44	ITCH	297:300	PPPY	ITCH,NEDD4	0.8077	More...
Q86YQ8	Copine-8	ITCH	550:553	PPPY	ITCH,NEDD4	0.743	More...
Q8IW70	Transmembrane protein 151B	ITCH	527:530	PPPY	ITCH,NEDD4	0.9917	More...
Q8WV15	Transmembrane protein 255B	ITCH	321:324	PPPY	ITCH,NEDD4	0.9864	More...
Q8WVE6	Transmembrane protein 171	ITCH	224:227	PPPY	ITCH,NEDD4	0.991	More...
Q8WXE0	Caskin-2	ITCH	751:754	PPPY	ITCH,NEDD4	0.6879	More...
Q96G27	WW domain-binding protein 1	ITCH	138:141	PPPY	ITCH,NEDD4	0.8782	More...
Q9H0R4	Haloacid dehalogenase-like hydrolase domain-containing protein 2	ITCH	238:241	PPPY	ITCH,NEDD4	0.9907	More...
Q9H1C7	Cysteine-rich and transmembrane domain-containing protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9391	More...
A4D263	Spermatogenesis-associated protein 48	ITCH	85:88	PPPY	ITCH,NEDD4	0.8985	More...
Q86XN7	Proline and serine-rich protein 1	ITCH	233:236	PPPY	ITCH,NEDD4	0.9855	More...
Q8IXP5	Uncharacterized protein C11orf53	ITCH	179:182	PPPY	ITCH,NEDD4	0.9512	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPPY

Degron related mutations and impact score

Drug responses associated with DDR1 mutations

All proteins holding degron of PPPY